功能细胞系

背景

自1986年全球首个鼠源单克隆抗体药物莫罗莫那单抗（muromonab-CD3）经美国FDA批准上市至今，抗体药物历经数十年的研究与发展，已经成为生物药中增长最快的领域并彻底改变了癌症等一系列疾病的治疗格局。目前，全球范围内已有近百个抗体类药物获批上市，在临床治疗、体外诊断、科学研究等领域发挥重要作用。

细胞水平的分析评价是体外进行药物有效性评估的重要指标之一，被广泛地应用在新药研发过程中。但是由于所选用细胞的局限性，很多传统的细胞水平活性分析方法有着灵敏度低，重复性差，操作复杂，检测周期长，通量低等缺点,。比如选用原代细胞的分析方法，由于原代细胞的批间差异大，导致分析方法非常不稳定，因此无法满足新药研发的需求。

通过基因工程方法构建的报告基因细胞株（Reporter cell line）被认为可以克服传统细胞水平分析方法缺点而被逐步广泛运用到新药研发的进程中。报告基因细胞株（Reporter cell line）以药物作用机制（MOA）为基础，在细胞内建立起靶点转导信号与报告基因表达的相关性，通过检测报告基因的表达情况以监控靶点信号通路转导，进而构建一种药物靶点特异性的模型细胞株。这类细胞株批间差小，且转入细胞内的检测信号强，以此为基础开发的分析方法灵敏度高，检测周期短，重复性好，并且操作简单。

为满足新药物研发的需求，ACROBiosystems采用荧光素酶报告基因系统建立报告基因细胞平台，持续开发系列高质量报告基因细胞株产品。ACRO开发的系列细胞株产品均通过功能性和稳定性验证，可以应用于信号传导功能研究、早期药物发现与筛选及CMC质控放行，为新药研发提供一个稳定且便捷的工具！

超高品质+兜底售后，给您不可不选择ACRO报告基因细胞株的五大理由！

应用场景

ADCC/ADCP功能验证

靶点及通路研究

Cross-linking药物评价

免疫检查点抗体研究

如需定制其他报告基因细胞系或过表达细胞系，欢迎点击此处了解详细信息

产品优势：

基于明确MOA设计，便于药物机制研究；

应用场景明确，方便客户选择；

配套产品供应，实现一站服务；

反应信号强，确保高灵敏度；

检测窗口大，适用不同药效筛选；

可稳定传代>20代，利于方法学验证；

可提供临床申报及CMC所需支持文件；

产品列表

ADCC/ADCP功能验证
靶点及通路研究
Cross-linking药物评价
免疫检查点药物研究

应用	Molecule	Cat. No.	Product description
ADCP	FcγRI(CD64A)	SCJUR-STF072	Human CD64 (Luc) Jurkat Reporter Cell Development Service
	FcγRIIa(CD32a)-H131	SCJUR-STF069	Human CD32a (131H) (Luc) Jurkat Reporter Cell Development Service
	FcγRIIa(CD32a)-R131	SCJUR-STF070	Human CD32a (131R) (Luc) Jurkat Reporter Cell Development Service
	FcRIIb (CD32b)	SCJUR-STF071	Human CD32b (Luc) Jurkat Reporter Cell Development Service
ADCC	FcRIIIa (CD16a)-V158	SCJUR-STF067	Human CD16a (158V) (Luc) Jurkat Reporter Cell Development Service
ADCC	FcRIIIa (CD16a)-F158	SCJUR-STF068	Human CD16a (158F) (Luc) Jurkat Reporter Cell Development Service

Molecule	Cat. No.	Product Description
IL-7 R alpha & TSLP R	CHEK-ATF045	Human TSLPR (Luc) HEK293 Reporter Cell
IL-5 R alpha/CD131	CHEK-ATF074	Human IL-5 R alpha/CD131 (Luc) HEK293 Reporter Cell
IL-4 R alpha/IL-13 R alpha 1	CHEK-ATF075	Human IL-4 R alpha/IL-13 R alpha 1 (Luc) HEK293 Reporter Cell
IL-11 R alpha	CHEK-ATF052	Human IL-11 R alpha (Luc) HEK293 Reporter Cell
EGF R	CHEK-ATF049	Human EGFR (Luc) HEK293 Reporter Cell
VEGF R2	CHEK-ATF044	Human VEGFR2 (Luc) HEK293 Reporter Cell
NFAT	SCJUR-STF046	NFAT (Luc) Jurkat Reporter Cell Development Service
NFAT	CHEK-ATF050	NFAT (Luc) HEK293 Reporter Cell
STAT3	CHEK-ATF047	STAT3 (Luc) HEK293 Reporter Cell
NF-κB	CHEK-ATF048	NF-κB (Luc) HEK293 Reporter Cell

Molecule	Cat. No.	Product Description
4-1BB	CHEK-ATF073	Human 4-1BB (Luc) HEK293 Reporter Cell
Fc gamma RIIIA / CD16a	SCCHO-ATP059L	CHO/Human CD16a (158V) Stable Cell Line (Low Expression) Development Service
Fc gamma RIIIA / CD16a	SCCHO-ATP059M	CHO/Human CD16a (158V) Stable Cell Line (Medium Expression) Development Service
Fc gamma RIIIA / CD16a	SCCHO-ATP059H	CHO/Human CD16a (158V) Stable Cell Line (High Expression) Development Service
Fc gamma RIIB / CD32b	SCCHO-ATP060L	CHO/Human CD32b Stable Cell Line (Low Expression) Development Service
Fc gamma RIIB / CD32b	SCCHO-ATP060M	CHO/Human CD32b Stable Cell Line (Medium Expression) Development Service
Fc gamma RIIB / CD32b	SCCHO-ATP060H	CHO/Human CD32b Stable Cell Line (High Expression) Development Service
Fc gamma RIIA / CD32a	SCCHO-ATP061L	CHO/Human CD32a Stable Cell Line (Low Expression) Development Service
Fc gamma RIIA / CD32a	SCCHO-ATP061M	CHO/Human CD32a Stable Cell Line (Medium Expression) Development Service
Fc gamma RIIA / CD32a	SCCHO-ATP061H	CHO/Human CD32a Stable Cell Line (High Expression) Development Service
Fc gamma RI / CD64	SCCHO-ATP062L	CHO/Human CD64 Stable Cell Line (Low Expression) Development Service
Fc gamma RI / CD64	SCCHO-ATP062M	CHO/Human CD64 Stable Cell Line (Medium Expression) Development Service
Fc gamma RI / CD64	SCCHO-ATP062H	CHO/Human CD64 Stable Cell Line (High Expression) Development Service
PD-L1	SCCHO-ATP077L	CHO/Human PD-L1 Stable Cell Line (Low Expression) Development Service
PD-L1	SCCHO-ATP077M	CHO/Human PD-L1 Stable Cell Line (Medium Expression) Development Service
PD-L1	SCCHO-ATP077H	CHO/Human PD-L1 Stable Cell Line (High Expression) Development Service

Molecule	Cat. No.	Product Description
PD-1/LAG-3	SCJUR-STF063	Human PD-1/LAG-3 (Luc) Jurkat Reporter Development Service
PD-1	SCJUR-STF064	Human PD-1 (Luc) Jurkat Reporter Cell Development Service
LAG-3	SCJUR-STF065	Human LAG-3 (Luc) Jurkat Reporter Cell Development Service
TIGIT	SCJUR-STF066	Human TIGIT (Luc) Jurkat Reporter Cell Development Service
PD-L1	SCRAJ-STT075	Raji/Human PD-L1 Stable Cell Line Development Service
CD155	SCRAJ-STT076	Raji/Human CD155 Stable Cell Line Development Service

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