登录 | 注册    关注公众号  
微信公众号
搜索
>产品&服务 > 功能细胞系

功能细胞系

背景
自1986年全球首个鼠源单克隆抗体药物莫罗莫那单抗(muromonab-CD3)经美国FDA批准上市至今,抗体药物历经数十年的研究与发展,已经成为生物药中增长最快的领域并彻底改变了癌症等一系列疾病的治疗格局。目前,全球范围内已有近百个抗体类药物获批上市,在临床治疗、体外诊断、科学研究等领域发挥重要作用。
细胞水平的分析评价是体外进行药物有效性评估的重要指标之一,被广泛地应用在新药研发过程中。但是由于所选用细胞的局限性,很多传统的细胞水平活性分析方法有着灵敏度低,重复性差,操作复杂,检测周期长,通量低等缺点,。比如选用原代细胞的分析方法,由于原代细胞的批间差异大,导致分析方法非常不稳定,因此无法满足新药研发的需求。
通过基因工程方法构建的报告基因细胞株(Reporter cell line)被认为可以克服传统细胞水平分析方法缺点而被逐步广泛运用到新药研发的进程中。报告基因细胞株(Reporter cell line)以药物作用机制(MOA)为基础,在细胞内建立起靶点转导信号与报告基因表达的相关性,通过检测报告基因的表达情况以监控靶点信号通路转导,进而构建一种药物靶点特异性的模型细胞株。这类细胞株批间差小,且转入细胞内的检测信号强,以此为基础开发的分析方法灵敏度高,检测周期短,重复性好,并且操作简单。
为满足新药物研发的需求,ACROBiosystems采用荧光素酶报告基因系统建立报告基因细胞平台,持续开发系列高质量报告基因细胞株产品。ACRO开发的系列细胞株产品均通过功能性和稳定性验证,可以应用于信号传导功能研究、早期药物发现与筛选及CMC质控放行,为新药研发提供一个稳定且便捷的工具!
应用场景
ADCC/ADCP功能验证
ADCC/ADCP功能验证
靶点及通路研究
靶点及通路研究
Cross-linking药物评价
Cross-linking药物评价
免疫检查点抗体研究
免疫检查点抗体研究
产品优势:

基于明确MOA设计,便于药物机制研究;

应用场景明确,方便客户选择;

配套产品供应,实现一站服务;

反应信号强,确保高灵敏度;

检测窗口大, 适用不同药效筛选;

可稳定传代>20代,利于方法学验证;

可提供临床申报及CMC所需支持文件;

产品列表
  • ADCC/ADCP功能验证
  • 靶点及通路研究
  • Cross-linking药物评价
  • 免疫检查点药物研究
应用 Molecule Cat. No. Product description
ADCP FcγRI(CD64A) SCJUR-STF072 Human CD64 (Luc) Jurkat Reporter Cell Development Service
FcγRIIa(CD32a)-H131 SCJUR-STF069 Human CD32a (131H) (Luc) Jurkat Reporter Cell Development Service
FcγRIIa(CD32a)-R131 SCJUR-STF070 Human CD32a (131R) (Luc) Jurkat Reporter Cell Development Service
FcRIIb (CD32b) SCJUR-STF071 Human CD32b (Luc) Jurkat Reporter Cell Development Service
ADCC FcRIIIa (CD16a)-V158 SCJUR-STF067 Human CD16a (158V) (Luc) Jurkat Reporter Cell Development Service
FcRIIIa (CD16a)-F158 SCJUR-STF068 Human CD16a (158F) (Luc) Jurkat Reporter Cell Development Service
Molecule Cat. No. Product Description
IL-7 R alpha & TSLP R CHEK-ATF045 Human TSLPR (Luc) HEK293 Reporter Cell
IL-5 R alpha CHEK-ATF074 Human IL-5 R alpha/CD131 (Luc) HEK293 Reporter Cell
EGF R CHEK-ATF049 Human EGFR (Luc) HEK293 Reporter Cell
VEGF R2 CHEK-ATF044 Human VEGFR2 (Luc) HEK293 Reporter Cell
NFAT SCJUR-STF046 NFAT (Luc) Jurkat Reporter Cell Development Service
NFAT CHEK-ATF050 NFAT (Luc) HEK293 Reporter Cell
STAT3 CHEK-ATF047 STAT3 (Luc) HEK293 Reporter Cell
NF-κB CHEK-ATF048 NF-κB (Luc) HEK293 Reporter Cell
Molecule Cat. No. Product Description
4-1BB CHEK-ATF073 Human 4-1BB (Luc) HEK293 Reporter Cell
Fc gamma RIIIA / CD16a SCCHO-ATP059L CHO/Human CD16a (158V) Stable Cell Line (Low Expression) Development Service
Fc gamma RIIIA / CD16a SCCHO-ATP059M CHO/Human CD16a (158V) Stable Cell Line (Medium Expression) Development Service
Fc gamma RIIIA / CD16a SCCHO-ATP059H CHO/Human CD16a (158V) Stable Cell Line (High Expression) Development Service
Fc gamma RIIB / CD32b SCCHO-ATP060L CHO/Human CD32b Stable Cell Line (Low Expression) Development Service
Fc gamma RIIB / CD32b SCCHO-ATP060M CHO/Human CD32b Stable Cell Line (Medium Expression) Development Service
Fc gamma RIIB / CD32b SCCHO-ATP060H CHO/Human CD32b Stable Cell Line (High Expression) Development Service
Fc gamma RIIA / CD32a  SCCHO-ATP061L CHO/Human CD32a Stable Cell Line (Low Expression) Development Service
Fc gamma RIIA / CD32a  SCCHO-ATP061M CHO/Human CD32a Stable Cell Line (Medium Expression) Development Service
Fc gamma RIIA / CD32a  SCCHO-ATP061H CHO/Human CD32a Stable Cell Line (High Expression) Development Service
Fc gamma RI / CD64 SCCHO-ATP062L CHO/Human CD64 Stable Cell Line (Low Expression) Development Service
Fc gamma RI / CD64 SCCHO-ATP062M CHO/Human CD64 Stable Cell Line (Medium Expression) Development Service
Fc gamma RI / CD64 SCCHO-ATP062H CHO/Human CD64 Stable Cell Line (High Expression) Development Service
PD-L1 SCCHO-ATP077L CHO/Human PD-L1 Stable Cell Line (Low Expression) Development Service
PD-L1 SCCHO-ATP077M CHO/Human PD-L1 Stable Cell Line (Medium Expression) Development Service
PD-L1 SCCHO-ATP077H CHO/Human PD-L1 Stable Cell Line (High Expression) Development Service
Molecule Cat. No. Product Description
PD-1/LAG-3 SCJUR-STF063 Human PD-1/LAG-3 (Luc) Jurkat Reporter Development Service
PD-1 SCJUR-STF064 Human PD-1 (Luc) Jurkat Reporter Cell Development Service
LAG-3 SCJUR-STF065 Human LAG-3 (Luc) Jurkat Reporter Cell Development Service
TIGHT SCJUR-STF066 Human TIGIT (Luc) Jurkat Reporter Cell Development Service
PD-L1 SCRAJ-STT075 Raji/Human PD-L1 Stable Cell Line Development Service
CD155 SCRAJ-STT076 Raji/Human CD155 Stable Cell Line Development Service

消息提示

请输入您的联系方式,再点击提交!

确定