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>产品&服务 > 功能细胞系

功能细胞系

功能细胞系
背景
应用场景
产品列表
背景
自1986年全球首个鼠源单克隆抗体药物莫罗莫那单抗（muromonab-CD3）经美国FDA批准上市至今，抗体药物历经数十年的研究与发展，已经成为生物药中增长最快的领域并彻底改变了癌症等一系列疾病的治疗格局。目前，全球范围内已有近百个抗体类药物获批上市，在临床治疗、体外诊断、科学研究等领域发挥重要作用。
细胞水平的分析评价是体外进行药物有效性评估的重要指标之一，被广泛地应用在新药研发过程中。但是由于所选用细胞的局限性，很多传统的细胞水平活性分析方法有着灵敏度低，重复性差，操作复杂，检测周期长，通量低等缺点,。比如选用原代细胞的分析方法，由于原代细胞的批间差异大，导致分析方法非常不稳定，因此无法满足新药研发的需求。
通过基因工程方法构建的报告基因细胞株（Reporter cell line）被认为可以克服传统细胞水平分析方法缺点而被逐步广泛运用到新药研发的进程中。报告基因细胞株（Reporter cell line）以药物作用机制（MOA）为基础，在细胞内建立起靶点转导信号与报告基因表达的相关性，通过检测报告基因的表达情况以监控靶点信号通路转导，进而构建一种药物靶点特异性的模型细胞株。这类细胞株批间差小，且转入细胞内的检测信号强，以此为基础开发的分析方法灵敏度高，检测周期短，重复性好，并且操作简单。
为满足新药物研发的需求，ACROBiosystems采用荧光素酶报告基因系统建立报告基因细胞平台，持续开发系列高质量报告基因细胞株产品。ACRO开发的系列细胞株产品均通过功能性和稳定性验证，可以应用于信号传导功能研究、早期药物发现与筛选及CMC质控放行，为新药研发提供一个稳定且便捷的工具！

超高品质+兜底售后，给您不可不选择ACRO报告基因细胞株的五大理由！

应用场景
ADCC/ADCP功能验证
ADCC/ADCP功能验证
靶点及通路研究
靶点及通路研究
Cross-linking药物评价
Cross-linking药物评价
免疫检查点抗体研究
免疫检查点抗体研究
如需定制其他报告基因细胞系或过表达细胞系，欢迎点击此处了解详细信息
产品优势：

基于明确MOA设计，便于药物机制研究；

应用场景明确，方便客户选择；

配套产品供应，实现一站服务；

反应信号强，确保高灵敏度；

检测窗口大， 适用不同药效筛选；

可稳定传代>20代，利于方法学验证；

可提供临床申报及CMC所需支持文件；

产品列表
  • ADCC/ADCP功能验证
  • 靶点及通路研究
  • Cross-linking药物评价
  • 免疫检查点药物研究
应用 Molecule Cat. No. Product description
ADCP FcγRI(CD64A) SCJUR-STF072 Human CD64 (Luc) Jurkat Reporter Cell Development Service
FcγRIIa(CD32a)-H131 SCJUR-STF069 Human CD32a (131H) (Luc) Jurkat Reporter Cell Development Service
FcγRIIa(CD32a)-R131 SCJUR-STF070 Human CD32a (131R) (Luc) Jurkat Reporter Cell Development Service
FcRIIb (CD32b) SCJUR-STF071 Human CD32b (Luc) Jurkat Reporter Cell Development Service
ADCC FcRIIIa (CD16a)-V158 SCJUR-STF067 Human CD16a (158V) (Luc) Jurkat Reporter Cell Development Service
FcRIIIa (CD16a)-F158 SCJUR-STF068 Human CD16a (158F) (Luc) Jurkat Reporter Cell Development Service
分子 货号 Reporter Cell Product Description
EGF R CHEK-ATF049 EGFR (Luc) HEK293 Reporter Cell
GCGR CHEK-ATF103 Human GCGR (Luc) HEK293 Reporter Cell
GIPR CHEK-ATF104 Human GIPR (Luc) HEK293 Reporter Cell
GLP-1R CHEK-ATF096 Human GLP-1R (Luc) HEK293 Reporter Cell
IGF-I R CHEK-ATF107 Human IGF-1 R (Luc) HEK293 Reporter Cell
IL-10 R alpha/IL-10 R beta CHEK-ATF095 Human IL-10 R alpha/IL-10 R beta (Luc) HEK293 Reporter Cell
IL-11 R alpha CHEK-ATF052 Human IL-11 R alpha (Luc) HEK293 Reporter Cell
IL-21 R CHEK-ATF051 Human IL-21 R/CD132 (Luc) HEK293 Reporter Cell
IL-31 RA / OSMR CHEK-ATF094 Human IL-31 RA/OSMR (Luc) HEK293 Reporter Cell
IL-4 R alpha/IL-13 R alpha 1 CHEK-ATF075 Human IL-4 R alpha/IL-13 R alpha 1 (Luc) HEK293 Reporter Cell
IL-5 R alpha/CD131 CHEK-ATF074 Human IL-5 R alpha/CD131 (Luc) HEK293 Reporter Cell
IL-7 R alpha CHEK-ATF099 Human IL-7 R alpha/CD132 (Luc) HEK293 Reporter Cell
IL-7 R alpha & TSLP R CHEK-ATF045 Human TSLP R (Luc) HEK293 Reporter Cell
NF-κB CHEK-ATF048 NF-κB (Luc) HEK293 Reporter Cell
NF-κB SCJUR-STF113 NF-kB (Luc) Jurkat Reporter Cell Development Service
NFAT CHEK-ATF050 NFAT (Luc) HEK293 Reporter Cell
NFAT SCJUR-STF046 NFAT (Luc) Jurkat Reporter Cell Development Service
NKp46 SCJUR-STF130 Human NKp46 (Luc) Jurkat Reporter Cell Development Service
RANK CHEK-ATF129 Human RANK (Luc) HEK293 Reporter Cell
STAT3 CHEK-ATF047 STAT3 (Luc) HEK293 Reporter Cell
TCF/LEF CHEK-ATF114 TCF/LEF (Luc) HEK293 Reporter Cell
TrkA CHEK-ATF093 Human TrkA (Luc) HEK293 Reporter Cell
VEGF R2 CHEK-ATF044 VEGFR2 (Luc) HEK293 Reporter Cell
分子 货号 Stable Cell Product Description
- CHEK-SP01 HEK293 Cell Line
ASGR1 CHEK-ATP080 HEK293/Human ASGR1 Stable Cell Line
B7-H3 CHEK-ATP118 HEK293/Human B7-H3 Stable Cell Line
B7-H3 (4Ig) CHEK-ATP117 HEK293/Human B7-H3 (4Ig) Stable Cell Line
B7-H4 CHEK-ATP126 HEK293/Human B7-H4 Stable Cell Line
c-MET SCCHO-ATP141 CHO/Human c-MET Stable Cell Line Development Service
Cadherin-6 CHEK-ATP127 HEK293/Human Cadherin-6 Stable Cell Line
CCR8 CHEK-ATP140 HEK293/Human CCR8 Stable Cell Line
CEACAM5 CHEK-ATP083 HEK293/Human CEACAM5 Stable Cell Line
CEACAM5 SCCHO-ATP081 CHO/Human CEACAM5 Stable Cell Line Development Service
Claudin-1 CHEK-ATP124 HEK293/Human Claudin-1 Stable Cell Line
Claudin-6 CHEK-ATP138 HEK293/Human Claudin-6 Stable Cell Line
Claudin-9 CHEK-ATP139 HEK293/Human Claudin-9 Stable Cell Line
DLL3 CHEK-ATP090 HEK293/Human DLL3 Stable Cell Line
DLL3 SCCHO-ATP111 CHO/Human DLL3 Stable Cell Line Development Service
ENPP3 CHEK-ATP122 HEK293/Human ENPP3 Stable Cell Line
FOLR1 CHEK-ATP091 HEK293/Human FOLR1 Stable Cell Line
GPC3 CHEK-ATP092 HEK293/Human Glypican-3 (GPC3) Stable Cell Line
GPC3 SCCHO-ATP112 CHO/Human Glypican-3 (GPC3) Stable Cell Line
IGF-I R CNIH-ATP102 NIH-3T3/Human IGF-1 R Stable Cell Line Development Service
Integrin alpha V beta 6 CHEK-ATP125 HEK293/Human Integrin alpha V beta 6 Stable Cell Line
LILRB4 CHEK-ATP088 HEK293/Human LILRB4 Stable Cell Line
LILRB4 SCCHO-ATP087 CHO/Human LILRB4 Stable Cell Line Development Service
LRRC15 CHEK-ATP123 HEK293/Human LRRC15 Stable Cell Line
LY6G6D CHEK-ATP137 HEK293/Human LY6G6D Stable Cell Line
Mesothelin CHEK-ATP119 HEK293/Human Mesothelin Stable Cell Line
Mesothelin SCCHO-ATP120 CHO/Human Mesothelin Stable Cell Line Development Service
NAPI-IIb CHEK-ATP116 HEK293/Human NAPI-IIb Stable Cell Line
ROR1 CHEK-ATP084 HEK293/Human ROR1 Stable Cell Line
ROR1 SCCHO-ATP083 CHO/Human ROR1 Stable Cell Line Development Service
STEAP1 CHEK-ATP100 HEK293/Human STEAP1 Stable Cell Line
STEAP1 SCCHO-ATP121 CHO/Human STEAP1 Stable Cell Line Development Service
TL1A CHEK-ATP142 HEK293/Human TL1A Stable Cell Line
TMPRSS2 CHEK-ATP101 HEK293/Human TMPRSS2-HA-P2A-mGFP Stable Cell Line
Transferrin CHEK-ATP115 HEK293/Human Transferrin Stable Cell Line
TSHR CHEK-ATP086 HEK293/Human TSHR Stable Cell Line
TSHR SCCHO-ATP085 CHO/Human TSHR Stable Cell Line Development Service
Molecule Cat. No. Product Description
4-1BB CHEK-ATF073 Human 4-1BB (Luc) HEK293 Reporter Cell
CD40 CHEK-ATF097 Human CD40 (Luc) HEK293 Reporter Cell
Fc gamma RI / CD64 SCCHO-ATP062H CHO/Human CD64 Stable Cell Line (High Expression) Development Service
Fc gamma RI / CD64 SCCHO-ATP062L CHO/Human CD64 Stable Cell Line (Low Expression) Development Service
Fc gamma RI / CD64 SCCHO-ATP062M CHO/Human CD64 Stable Cell Line (Medium Expression) Development Service
Fc gamma RIIA / CD32a SCCHO-ATP061H CHO/Human CD32a Stable Cell Line (High Expression) Development Service
Fc gamma RIIA / CD32a SCCHO-ATP061L CHO/Human CD32a Stable Cell Line (Low Expression) Development Service
Fc gamma RIIA / CD32a SCCHO-ATP061M CHO/Human CD32a Stable Cell Line (Medium Expression) Development Service
Fc gamma RIIB / CD32b SCCHO-ATP060H CHO/Human CD32b Stable Cell Line (High Expression) Development Service
Fc gamma RIIB / CD32b SCCHO-ATP060L CHO/Human CD32b Stable Cell Line (Low Expression) Development Service
Fc gamma RIIB / CD32b SCCHO-ATP060M CHO/Human CD32b Stable Cell Line (Medium Expression) Development Service
Fc gamma RIIIA / CD16a SCCHO-ATP059H CHO/Human CD16a (158V) Stable Cell Line (High Expression) Development Service
Fc gamma RIIIA / CD16a SCCHO-ATP059L CHO/Human CD16a (158V) Stable Cell Line (Low Expression) Development Service
Fc gamma RIIIA / CD16a SCCHO-ATP059M CHO/Human CD16a (158V) Stable Cell Line (Medium Expression) Development Service
PD-L1 SCCHO-ATP077H CHO/Human PD-L1 Stable Cell Line (High Expression) Development Service
PD-L1 SCCHO-ATP077L CHO/Human PD-L1 Stable Cell Line (Low Expression) Development Service
PD-L1 SCCHO-ATP077M CHO/Human PD-L1 Stable Cell Line (Medium Expression) Development Service
Molecule Cat. No. Product Description
BTLA SCCHO-ATP110 CHO/Human BTLA Stable Cell Line Development Service
BTLA SCJUR-STF106 Human BTLA (Luc) Jurkat Reporter Cell Development Service
CD155 SCRAJ-STT076 Raji/Human CD155 Stable Cell Line Development Service
Fc gamma RIIIA / CD16a SCJUR-STF067 Human CD16a (158V) (Luc) Jurkat Reporter Cell Development Service
HVEM CHEK-ATF105 Human HVEM (Luc) HEK293 Reporter Cell
HVEM SCRAJ-STF108 Raji/Human HVEM Stable Cell Line Development Service
LAG3 SCJUR-STF065 Human LAG-3 (Luc) Jurkat Reporter Cell Development Service
LIGHT SCCHO-ATP109 CHO/Human LIGHT Stable Cell Line Development Service
PD-1 SCJUR-STF064 Human PD-1 (Luc) Jurkat Reporter Cell Development Service
PD-L1 SCRAJ-STT075 Raji/Human PD-L1 Stable Cell Line Development Service
PD1/LAG3 SCJUR-STF063 Human PD-1/LAG-3 (Luc) Jurkat Reporter cell Development Service
TIGIT SCJUR-STF066 Human TIGIT (Luc) Jurkat Reporter Cell Development Service
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