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Mesothelin信息

英文名称:Mesothelin
中文名称:间皮素
靶点别称:Pre-pro-megakaryocyte-potentiating factor,Mesothelin,MSLN,CAK1 Antigen,MPF,Soluble MPF Mesothelin Related Protein,Megakaryocyte Potentiating Factor,SMRP,CAK1
上市药物数量:0
临床药物数量:18
最高研发阶段:临床二期

Mesothelin产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
MSN-H82E9
Human
Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™ (MALS verified) DMF Filed
MSN-H526x
Human
Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H826x
Human
Biotinylated Human Mesothelin / MSLN (296-580), Fc Tag, ultra sensitivity (primary amine labeling) (MALS verified)
MSN-H8223
Human
Biotinylated Human Mesothelin / MSLN (296-580) Protein, His Tag, ultra sensitivity (primary amine labeling)
MSN-H5222
Human
Human Mesothelin / MSLN (37-286) Protein, His Tag
MSN-H5253
Human
Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H522a
Human
Human Mesothelin / MSLN (296-580) Protein, His Tag, low endotoxin (MALS verified)
MSN-H82F6
Human
Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc,Avitag™
MSN-HF253
Human
FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF223
Human
FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HG2P4
Human
GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HR2P4
Human
RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF25x
Human
FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-M52H3
Mouse
Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-C52H6
Cynomolgus
Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-HP2H5
Human
PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation) DMF Filed
MSN-M82E7
Mouse
Biotinylated Mouse Mesothelin / MSLN Protein, His,Avitag™
MBS-K024
Human
Human Mesothelin-coupled Magnetic Beads
MSN-R52H4
Rat
Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-H82E7
Human
Biotinylated Human Mesothelin / MSLN (296-600) Protein, His,Avitag™ (MALS verified)
MSN-HF2H3
Human
FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HP2H8
Human
PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H6
Human
APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H7
Human
APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
 
评论(5)
MSN-C52H6|Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
  1. 156XXXXXXX8
  2. 1人赞
  3. 我们采购猴的MSLN蛋白,主要是用于筛选能够同时结合人MSLN和猴MSLN的药用抗体分子,主要用在前期的小鼠免疫和后期的ELISA筛选,若能结合人的MSLN,也可以结合猴的MSLN,则有利于后期毒理等模型的选择。
  4. 2022-04-06
MSN-R52H4|Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
  1. 156XXXXXXX8
  2. 1人赞
  3. 我们采购大鼠的MSLN蛋白,主要是用于杂交瘤平台筛选MSLN的药用抗体分子,主要是用在前期的筛选阶段,检测我们通过杂交瘤筛选获得的抗体的种属交叉情况,通过ELISA检测是否在结合人的MSLN的同时,也可以结合大鼠的MSLN,从而支持后期在大鼠上开展毒理实验。
  4. 2022-04-06
MSN-M52H3|Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
  1. 156XXXXXXX8
  2. 1人赞
  3. 我们采购小鼠的MSLN蛋白,主要是用于杂交瘤平台筛选MSLN的药用抗体分子,主要是用在前期的筛选阶段,检测我们通过杂交瘤筛选获得的抗体的种属交叉情况,通过ELISA检测是否在结合人的MSLN的同时,也可以结合小鼠的MSLN。
  4. 2022-04-06
 

Mesothelin 分子别名

MSLN,Mesothelin,MPF

Mesothelin 分子背景

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin 前沿进展

Mesothelin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
RNA-Meso-CIR-T RNA-Meso-CIR-T 临床一期 诺华制药, 宾夕法尼亚大学 间皮组织肿瘤 详情
Anti-mesothelin CAR-T (Pregene) 临床阶段不明 普瑞金(深圳)生物技术有限公司 胸水 详情
Autologous Mesothelin-specific TCR-T Cell Therapy (Lonza Walkersville) 临床一期 胰腺癌 详情
Anetumab ravtansine BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343 临床一期 拜耳, Morphosys 卵巢癌, 肿瘤, 间皮组织肿瘤, 非小细胞肺癌 详情
Anti-MESO CAR-T cell(Ruijin Hospital) 临床一期 上海交通大学医学院附属瑞金医院 肿瘤 详情
Gavocabtagene autoleucel TC-210 临床二期 Tcr2 Therapeutics 卵巢癌, 间皮组织肿瘤, 胆管上皮癌, 非小细胞肺癌 详情
iCasp9M28z iCasp9M28z 临床一期 Memorial Sloan Kettering Cancer Center 间皮组织肿瘤, 乳腺癌, 肺癌, 转移癌 详情
LMB-100 LMB-100; RG-7787; RO-6927005 临床二期 罗氏 肿瘤, 间皮组织肿瘤 详情
RC-88 RC-88 临床一期 荣昌生物制药(烟台)股份有限公司 实体瘤 详情
MCY-M11 MCY-M11 临床一期 Maxcyte 卵巢癌, 间皮组织肿瘤, 腹膜癌, 输卵管癌, 腺癌 详情
Amatuximab MORAb-009; MORAB-009-006 临床二期 美国国立癌症研究所 卵巢癌, 肿瘤, 胰腺癌, 间皮组织肿瘤, 非小细胞肺癌 详情
KD-021 (Nanjing KAEDI Biotech) KD-021 临床一期 南京凯地生物科技有限公司 肿瘤 详情
anti-mesothelin thorium-227 labeled antibody chelator conjugate BAY-2287411 临床一期 拜耳 卵巢癌, 间皮组织肿瘤, 胰腺导管癌, 腺癌 详情
LCAR-M23 临床一期 南京传奇生物科技有限公司 卵巢上皮癌 详情
anti-MESO CAR-T cells (Zhejiang University) 临床二期 浙江大学 卵巢癌 详情
ATA-2271 ATA-2271 临床一期 Memorial Sloan Kettering Cancer Center, Atara Biotherapeutics, 拜耳 间皮组织肿瘤 详情
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute) 临床二期 上海细胞治疗研究院 肿瘤 详情
Anti-mesothelin CAR-NK 临床一期 国健呈诺生物科技(北京)有限公司 卵巢上皮癌 详情

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