Mesothelin 靶点蛋白|抗体药物|临床药物信息

Mesothelin信息

英文名称：Mesothelin
中文名称：间皮素
靶点别称：Pre-pro-megakaryocyte-potentiating factor，Mesothelin，MSLN，CAK1 Antigen，MPF，Soluble MPF Mesothelin Related Protein，Megakaryocyte Potentiating Factor，SMRP，CAK1

上市药物数量：0
临床药物数量：25
最高研发阶段：临床二期

Mesothelin产品列表

筛选结果

产品库

在线 (28)

物种

标签

属性

标记

货号	物种	产品描述
MSN-H82E9	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™ (MALS verified) DMF Filed
MSN-H526x	Human	Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H826x	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc Tag, ultra sensitivity (primary amine labeling) (MALS verified)
MSN-H8223	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, His Tag, ultra sensitivity (primary amine labeling)
MSN-H5222	Human	Human Mesothelin / MSLN (37-286) Protein, His Tag
MSN-H5253	Human	Human Mesothelin / MSLN (296-580) Protein, Fc Tag, premium grade
MSN-H522a	Human	Human Mesothelin / MSLN (296-580) Protein, His Tag, premium grade
MSN-H82F6	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc,Avitag™, premium grade
MSN-HF253	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF223	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HG2P4	Human	GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HR2P4	Human	RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF25x	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-M52H3	Mouse	Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-C52H6	Cynomolgus	Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-HP2H5	Human	PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation) DMF Filed
MSN-M82E7	Mouse	Biotinylated Mouse Mesothelin / MSLN Protein, His,Avitag™
MBS-K024	Human	Human Mesothelin-coupled Magnetic Beads
MSN-R52H4	Rat	Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-H82E7	Human	Biotinylated Human Mesothelin / MSLN (296-600) Protein, His,Avitag™ (MALS verified)
MSN-HF2H3	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HP2H8	Human	PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H6	Human	APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H7	Human	APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
MSN-HA2H8	Human	Alexa Fluor 555-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H5	Human	Alexa Fluor 647-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H9	Human	Alexa Fluor 488-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-H5267	Human	Human Mesothelin / MSLN (391-598) Protein, Fc Tag (MALS verified)

MSN-H82E9|Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™ (MALS verified) DMF Filed

187XXXXXXX9

4人赞

使用该抗体对细胞产品进行流式检测，分析细胞阳性率。结果显示，该抗体特异性强，阳性群分群明显，下图显示在使用量为0.5微升时，细胞流式结果。
>
2022-01-29

MSN-HP2H5|PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation) DMF Filed

138XXXXXXX6

3人赞

我们已使用Acro品牌的MSLN生物素化间标抗原及PE直标抗原用于流式实验检测，并考察了生物素化间标的稳定性，结果显示-80度条件保存4个月稳定性仍很好。
>
2021-09-16

MSN-C52H6|Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)

156XXXXXXX8

2人赞

我们采购猴的MSLN蛋白，主要是用于筛选能够同时结合人MSLN和猴MSLN的药用抗体分子，主要用在前期的小鼠免疫和后期的ELISA筛选，若能结合人的MSLN，也可以结合猴的MSLN，则有利于后期毒理等模型的选择。
2022-04-06

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Mesothelin 分子别名

MSLN,Mesothelin,MPF

Mesothelin 分子背景

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin 前沿进展

Mesothelin临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
RNA-Meso-CIR-T	RNA-Meso-CIR-T	临床一期	诺华制药, 宾夕法尼亚大学	间皮组织肿瘤	详情
Anti-mesothelin CAR-T (Pregene)		临床阶段不明	普瑞金（深圳）生物技术有限公司	胸水	详情
Autologous Mesothelin-specific TCR-T Cell Therapy (Lonza Walkersville)		临床一期	弗莱德哈钦森癌症研究中心	胰腺癌, 胰腺导管癌	详情
Anti-mesothelin CAR-NK cell therapy(Guojianchengnuo)	ALF-101	临床一期	国健呈诺生物科技（北京）有限公司	卵巢上皮癌	详情
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute)		临床二期	上海细胞治疗研究院	肿瘤	详情
Anetumab ravtansine	BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343	临床二期	拜耳, Morphosys Ag	卵巢癌, 胸膜孤立性纤维瘤, 浆液性囊腺癌, 肿瘤, 胰腺癌, 间皮组织肿瘤, 腹膜癌, 肺癌, 输卵管癌, 子宫内膜样癌	详情
Gavocabtagene autoleucel	TC-210	临床二期	Tcr2 Therapeutics Inc	卵巢癌, 间皮组织肿瘤, 胆管上皮癌, 非小细胞肺癌	详情
LD013 CAR T-cell therapy (Nanjing Landun Biotechnology)	LD013; LD-013	临床一期	南京蓝盾生物科技有限公司	实体瘤, 卵巢癌	详情
Anti-MESO CAR-T cell(Ruijin Hospital)		临床一期	瑞金医院	实体瘤, 肿瘤	详情
SynKIR-110	SynKIR-meso; SynKIR™-110	临床一期	Verismo Therapeutics Inc	卵巢癌, 间皮组织肿瘤, 胆管上皮癌	详情
HPN-536	HPN-536	临床二期	Harpoon Therapeutics	肿瘤	详情
anti-MESO CAR-T cells (Zhejiang University)		临床二期	浙江大学, 上海恒润达生生物科技股份有限公司	卵巢癌	详情
iCasp9M28z	iCasp9M28z	临床二期	Memorial Sloan Kettering Cancer Center	肋膜疾病, 间皮组织肿瘤, 乳腺癌, 肺癌, 转移癌	详情
RC-88	RC-88	临床二期	荣昌生物制药（烟台）股份有限公司	实体瘤, 肿瘤	详情
Anti-mesothelin CAR T cell therapy (UTC Therapeutics Inc)		临床一期	UTC Therapeutics Inc	实体瘤	详情
Inezetamab	AMG-994	临床一期	安进	实体瘤, 肿瘤	详情
CART-meso	CART-meso	临床一期	诺华制药, 宾夕法尼亚大学	卵巢癌, 转移性上皮癌, 卵巢上皮癌, 胰腺癌, 肺腺癌, 间皮组织肿瘤, 乳腺癌, 输卵管癌	详情
AB-1015	AB-1015	临床一期	Arsenal Biosciences Inc	卵巢癌, 卵巢上皮癌	详情
PM-3006	PM-3006	临床一期	普米斯生物技术（珠海）有限公司		详情
anti-mesothelin thorium-227 labeled antibody chelator conjugate	BAY-2287411	临床一期	拜耳	卵巢癌, 间皮组织肿瘤, 胰腺导管癌, 腺癌	详情
KD-021	KD-021	临床一期	南京凯地生物科技有限公司	肿瘤	详情
RD-138	RD-138	临床一期	南京驯鹿医疗技术有限公司	多发性骨髓瘤	详情
LMB-100	LMB-100; RG-7787; RO-6927005	临床二期	罗氏	转移性上皮癌, 间皮肿瘤, 肿瘤, 肺腺癌, 胰腺癌, 间皮组织肿瘤, 胆管上皮癌, 恶性胸腔积液, 肺癌, 非小细胞肺癌	详情

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Mesothelin