Mesothelin 靶点蛋白|抗体药物|临床药物信息

Mesothelin信息

英文名称：Mesothelin
中文名称：间皮素
靶点别称：Pre-pro-megakaryocyte-potentiating factor，Mesothelin，MSLN，CAK1 Antigen，MPF，Soluble MPF Mesothelin Related Protein，Megakaryocyte Potentiating Factor，SMRP，CAK1

上市药物数量：0
临床药物数量：18
最高研发阶段：临床二期

Mesothelin产品列表

筛选结果

产品库

在线 (27)

物种

标签

属性

标记

货号	物种	产品描述
MSN-H82E9	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™ (MALS verified) DMF Filed
MSN-H526x	Human	Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H826x	Human	Biotinylated Human Mesothelin / MSLN (296-580), Fc Tag, ultra sensitivity (primary amine labeling) (MALS verified)
MSN-H8223	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, His Tag, ultra sensitivity (primary amine labeling)
MSN-H5222	Human	Human Mesothelin / MSLN (37-286) Protein, His Tag
MSN-H5253	Human	Human Mesothelin / MSLN (296-580) Protein, Fc Tag, premium grade
MSN-H522a	Human	Human Mesothelin / MSLN (296-580) Protein, His Tag, premium grade
MSN-H82F6	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc,Avitag™
MSN-HF253	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF223	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HG2P4	Human	GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HR2P4	Human	RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF25x	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-M52H3	Mouse	Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-C52H6	Cynomolgus	Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-HP2H5	Human	PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation) DMF Filed
MSN-M82E7	Mouse	Biotinylated Mouse Mesothelin / MSLN Protein, His,Avitag™
MBS-K024	Human	Human Mesothelin-coupled Magnetic Beads
MSN-R52H4	Rat	Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-H82E7	Human	Biotinylated Human Mesothelin / MSLN (296-600) Protein, His,Avitag™ (MALS verified)
MSN-HF2H3	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HP2H8	Human	PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H6	Human	APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H7	Human	APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
MSN-HA2H8	Human	Alexa Fluor 555-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H5	Human	Alexa Fluor 647-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H9	Human	Alexa Fluor 488-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining

MSN-H82E9|Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™ (MALS verified) DMF Filed

187XXXXXXX9

4人赞

使用该抗体对细胞产品进行流式检测，分析细胞阳性率。结果显示，该抗体特异性强，阳性群分群明显，下图显示在使用量为0.5微升时，细胞流式结果。
>
2022-01-29

MSN-HP2H5|PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation) DMF Filed

138XXXXXXX6

3人赞

我们已使用Acro品牌的MSLN生物素化间标抗原及PE直标抗原用于流式实验检测，并考察了生物素化间标的稳定性，结果显示-80度条件保存4个月稳定性仍很好。
>
2021-09-16

MSN-R52H4|Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)

156XXXXXXX8

1人赞

我们采购大鼠的MSLN蛋白，主要是用于杂交瘤平台筛选MSLN的药用抗体分子，主要是用在前期的筛选阶段，检测我们通过杂交瘤筛选获得的抗体的种属交叉情况，通过ELISA检测是否在结合人的MSLN的同时，也可以结合大鼠的MSLN，从而支持后期在大鼠上开展毒理实验。
2022-04-06

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Mesothelin 分子别名

MSLN,Mesothelin,MPF

Mesothelin 分子背景

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin 前沿进展

Mesothelin临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
RNA-Meso-CIR-T	RNA-Meso-CIR-T	临床一期	诺华制药, 宾夕法尼亚大学	间皮组织肿瘤	详情
Anti-mesothelin CAR-T (Pregene)		临床阶段不明	普瑞金（深圳）生物技术有限公司	胸水	详情
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute)		临床二期	上海细胞治疗研究院	肿瘤	详情
KD-021	KD-021	临床一期		肿瘤	详情
PM-3006	PM-3006	临床一期	普米斯生物技术（珠海）有限公司		详情
LCAR-M23			南京传奇生物科技有限公司		详情
Inezetamab	AMG-994		安进		详情
Autologous Mesothelin-specific TCR-T Cell Therapy (Lonza Walkersville)		临床一期		胰腺癌	详情
Anti-MESO CAR-T cell(Ruijin Hospital)			上海交通大学医学院附属瑞金医院	肿瘤	详情
BMS-986148	BMS-986148		百时美施贵宝		详情
anti-mesothelin thorium-227 labeled antibody chelator conjugate	BAY-2287411		拜耳		详情
RG-7600	RG-7600; DMOT-4039A		基因泰克		详情
anti-MESO CAR-T cells (Zhejiang University)			浙江大学		详情
ABBV-428	ABBV-428; ABBV428		艾伯维		详情
Gavocabtagene autoleucel	TC-210		Tcr2 Therapeutics		详情
iCasp9M28z	iCasp9M28z		Memorial Sloan Kettering Cancer Center		详情
Amatuximab	MORAb-009; MORAB-009-006		美国国立癌症研究所		详情
CART-meso	CART-meso		诺华制药, 宾夕法尼亚大学		详情
RC-88	RC-88	临床二期	荣昌生物制药（烟台）股份有限公司	实体瘤	详情
Anti-mesothelin CAR T cell therapy (Shanghai GeneChem)			上海吉凯基因医学科技股份有限公司		详情
Anti-mesothelin CAR-NK cell therapy(Guojianchengnuo)	ALF-101	临床一期	国健呈诺生物科技（北京）有限公司	卵巢上皮癌	详情
Anetumab ravtansine	BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343	临床一期	拜耳, Morphosys	卵巢癌, 肿瘤, 胰腺癌, 间皮组织肿瘤	详情

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Mesothelin