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Mesothelin信息

英文名称:Mesothelin
中文名称:间皮素
靶点别称:Pre-pro-megakaryocyte-potentiating factor,Mesothelin,MSLN,CAK1 Antigen,MPF,Soluble MPF Mesothelin Related Protein,Megakaryocyte Potentiating Factor,SMRP,CAK1
上市药物数量:0
临床药物数量:12
最高研发阶段:临床二期

Mesothelin产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
MSN-H826x
Human
Biotinylated Human Mesothelin / MSLN (296-580), Fc Tag, ultra sensitivity (primary amine labeling) (MALS verified)
MSN-H8223
Human
Biotinylated Human Mesothelin / MSLN (296-580) Protein, His Tag, ultra sensitivity (primary amine labeling)
MSN-H5223
Human
Human Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-H526x
Human
Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H5222
Human
Human Mesothelin / MSLN (37-286) Protein, His Tag
MSN-H82E9
Human
Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™ (MALS verified)
MSN-H5253
Human
Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H522a
Human
Human Mesothelin / MSLN (296-580) Protein, His Tag, low endotoxin
MSN-H82F6
Human
Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc,Avitag
MSN-HF253
Human
FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF223
Human
FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HG2P4
Human
GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HR2P4
Human
RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF25x
Human
FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-M52H3
Mouse
Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-C52H6
Cynomolgus
Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-HP2H5
Human
PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
MSN-M82E7
Mouse
Biotinylated Mouse Mesothelin / MSLN Protein, His,Avitag™
MBS-K024
Human
Human Mesothelin-coupled Magnetic Beads
MSN-R52H4
Rat
Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
 
评论(1)
MSN-H5223|Human Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
  1. 136XXXXXXX4
  2. 0人赞
  3. 货号MSN-H5223的蛋白Human Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)为293细胞表达纯化的,经我们实验室ELISA检测,其活性与我们用E. coli表达、变复性纯化的蛋白相当;因MSLN(296-580)有潜在的糖基化修饰位点(预测有三个;未发表的晶体结构中仅发现1个)—— ACRO未来如能在所提供的各种有糖基化修饰的蛋白中增加糖型检测结果(质谱等),会卖得更好
  4. 2021-08-23
 

Mesothelin 分子别名

MSLN,Mesothelin,MPF

Mesothelin 分子背景

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin 前沿进展

Mesothelin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
iCasp9M28z iCasp9M28z 临床一期 Memorial Sloan Kettering Cancer Center 间皮组织肿瘤, 乳腺癌, 肺癌, 转移癌 详情
LMB-100 LMB-100; RG-7787; RO-6927005 临床二期 罗氏 肿瘤, 间皮组织肿瘤 详情
ATA-2271 ATA-2271 临床一期 Memorial Sloan Kettering Cancer Center, Atara Biotherapeutics 间皮组织肿瘤 详情
MCY-M11 MCY-M11 临床一期 Maxcyte 卵巢癌, 间皮组织肿瘤, 腹膜癌, 输卵管癌, 腺癌 详情
BMS-986148 BMS-986148 临床二期 百时美施贵宝 肿瘤 详情
RNA-Meso-CIR-T RNA-Meso-CIR-T 临床一期 诺华制药, 宾夕法尼亚大学 间皮组织肿瘤 详情
Anetumab ravtansine BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343 临床二期 拜耳, Morphosys 卵巢癌, 肿瘤, 间皮组织肿瘤, 非小细胞肺癌 详情
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute) 临床二期 上海细胞治疗研究院 肿瘤 详情
KD-021 (Nanjing KAEDI Biotech) KD-021 临床一期 南京凯地生物科技有限公司 肿瘤 详情
Anti-mesothelin CAR-T (Pregene) 临床阶段不明 普瑞金(深圳)生物技术有限公司 胸水 详情
Anti-mesothelin CAR-T (Legend) 临床一期 卵巢癌 详情
Autologous Mesothelin-specific TCR-T Cell Therapy (Lonza Walkersville) 详情
anti-mesothelin thorium-227 labeled antibody chelator conjugate BAY-2287411 临床一期 拜耳 卵巢癌, 间皮组织肿瘤 详情
Amatuximab MORAb-009; MORAB-009-006 临床二期 美国国立癌症研究所 卵巢癌, 肿瘤, 胰腺癌, 间皮组织肿瘤, 非小细胞肺癌 详情
ABBV-428 ABBV-428; ABBV428 临床一期 艾伯维 实体瘤 详情
Anti-MESO CAR-T cell(Ruijin Hospital) 临床一期 上海交通大学医学院附属瑞金医院 肿瘤 详情

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