Mesothelin 靶点蛋白|抗体药物|临床药物信息

Mesothelin信息

英文名称：Mesothelin
中文名称：间皮素
靶点别称：Pre-pro-megakaryocyte-potentiating factor，Mesothelin，MSLN，CAK1 Antigen，MPF，Soluble MPF Mesothelin Related Protein，Megakaryocyte Potentiating Factor，SMRP，CAK1

上市药物数量：0
临床药物数量：12
最高研发阶段：临床二期

Mesothelin产品列表

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产品库

物种

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属性

标记

货号	物种	产品描述
MSN-H826x	Human	Biotinylated Human Mesothelin / MSLN (296-580), Fc Tag, ultra sensitivity (primary amine labeling) (MALS verified)
MSN-H8223	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, His Tag, ultra sensitivity (primary amine labeling)
MSN-H5223	Human	Human Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-H526x	Human	Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H5222	Human	Human Mesothelin / MSLN (37-286) Protein, His Tag
MSN-H82E9	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™ (MALS verified)
MSN-H5253	Human	Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H522a	Human	Human Mesothelin / MSLN (296-580) Protein, His Tag, low endotoxin
MSN-H82F6	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc,Avitag
MSN-HF253	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF223	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HG2P4	Human	GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HR2P4	Human	RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF25x	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-M52H3	Mouse	Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-C52H6	Cynomolgus	Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-HP2H5	Human	PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
MSN-M82E7	Mouse	Biotinylated Mouse Mesothelin / MSLN Protein, His,Avitag™
MBS-K024	Human	Human Mesothelin-coupled Magnetic Beads
MSN-R52H4	Rat	Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)

MSN-H5223|Human Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)

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货号MSN-H5223的蛋白Human Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)为293细胞表达纯化的，经我们实验室ELISA检测，其活性与我们用E. coli表达、变复性纯化的蛋白相当；因MSLN(296-580)有潜在的糖基化修饰位点（预测有三个；未发表的晶体结构中仅发现1个）—— ACRO未来如能在所提供的各种有糖基化修饰的蛋白中增加糖型检测结果（质谱等），会卖得更好
2021-08-23

Mesothelin 分子别名

MSLN,Mesothelin,MPF

Mesothelin 分子背景

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin 前沿进展

Mesothelin临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
iCasp9M28z	iCasp9M28z	临床一期	Memorial Sloan Kettering Cancer Center	间皮组织肿瘤, 乳腺癌, 肺癌, 转移癌	详情
LMB-100	LMB-100; RG-7787; RO-6927005	临床二期	罗氏	肿瘤, 间皮组织肿瘤	详情
ATA-2271	ATA-2271	临床一期	Memorial Sloan Kettering Cancer Center, Atara Biotherapeutics	间皮组织肿瘤	详情
MCY-M11	MCY-M11	临床一期	Maxcyte	卵巢癌, 间皮组织肿瘤, 腹膜癌, 输卵管癌, 腺癌	详情
BMS-986148	BMS-986148	临床二期	百时美施贵宝	肿瘤	详情
RNA-Meso-CIR-T	RNA-Meso-CIR-T	临床一期	诺华制药, 宾夕法尼亚大学	间皮组织肿瘤	详情
Anetumab ravtansine	BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343	临床二期	拜耳, Morphosys	卵巢癌, 肿瘤, 间皮组织肿瘤, 非小细胞肺癌	详情
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute)		临床二期	上海细胞治疗研究院	肿瘤	详情
KD-021 (Nanjing KAEDI Biotech)	KD-021	临床一期	南京凯地生物科技有限公司	肿瘤	详情
Anti-mesothelin CAR-T (Pregene)		临床阶段不明	普瑞金（深圳）生物技术有限公司	胸水	详情
Anti-mesothelin CAR-T (Legend)		临床一期		卵巢癌	详情
Autologous Mesothelin-specific TCR-T Cell Therapy (Lonza Walkersville)					详情
anti-mesothelin thorium-227 labeled antibody chelator conjugate	BAY-2287411	临床一期	拜耳	卵巢癌, 间皮组织肿瘤	详情
Amatuximab	MORAb-009; MORAB-009-006	临床二期	美国国立癌症研究所	卵巢癌, 肿瘤, 胰腺癌, 间皮组织肿瘤, 非小细胞肺癌	详情
ABBV-428	ABBV-428; ABBV428	临床一期	艾伯维	实体瘤	详情
Anti-MESO CAR-T cell(Ruijin Hospital)		临床一期	上海交通大学医学院附属瑞金医院	肿瘤	详情

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Mesothelin