DLL3 靶点蛋白|抗体药物|临床药物信息

DLL3信息

英文名称：Delta-like protein 3
中文名称：δ样蛋白-3
靶点别称：DLL3，Delta (Drosophila)-Like 3，Delta Like Canonical Notch Ligand 3，Delta3，Drosophila Delta Homolog 3，Delta-Like 3，Delta-Like Protein 3，SCDO1，Delta-Like 3 (Drosophila)

上市药物数量：0
临床药物数量：5
最高研发阶段：临床三期

DLL3产品列表

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Protein (10)

标记

货号	物种	产品描述
DL3-H5255	Human	Human DLL3 Protein, Fc Tag (MALS verified)
DL3-H52H4	Human	Human DLL3 Protein, His Tag (MALS verified)
DL3-C52H3	Cynomolgus	Cynomolgus DLL3 Protein, His Tag
DL3-HF253	Human	FITC-Labeled Human DLL3 Protein, Fc Tag
DL3-HF2H4	Human	FITC-Labeled Human DLL3 Protein, His Tag
DL3-M52H3	Mouse	Mouse DLL3 Protein, His Tag
DL3-R52H3	Rat	Rat DLL3 Protein, His Tag
DL3-R52H4	Rhesus macaque	Rhesus macaque DLL3 Protein, His Tag
DL3-H82E4	Human	Biotinylated Human DLL3 Protein, His,Avitag™ (MALS verified)
DL3-H82F5	Human	Biotinylated Human DLL3 Protein, Fc,Avitag™

DL3-H52H4|Human DLL3 Protein, His Tag (MALS verified)

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用于免疫小鼠，目前实验显示血清效价很高，提示该蛋白活性很高；正在进一步开展细胞融合，应该会有不错的结果。同时该蛋白也用于活性方法开发，很重要。
2021-11-03

DLL3 分子别名

Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3

DLL3 分子背景

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

DLL3 前沿进展

DLL3临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
89Zr-DFO-SC16.56	89Zr-DFO-SC16.56	临床一期	Memorial Sloan Kettering Cancer Center	小细胞肺癌	详情
Rovalpituzumab tesirine	SC-0002; SC0001SCX; SC16LD6.5; SC0001-SCX; P256HB60FF	临床三期	Stemcentrx, 艾伯维	实体瘤, 小细胞肺癌, 胶质母细胞瘤, 甲状腺髓样癌, 前列腺癌, 神经内分泌癌, 黑色素瘤	详情
HPN-328	HPN-328	临床二期	Harpoon Therapeutics	小细胞肺癌	详情
Tarlatamab	AMG-757	临床一期	安进	小细胞肺癌, 前列腺癌	详情

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DLL3