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MHC-多肽复合物定制服务

MHC-多肽复合物定制服务
背景
MHC(major histocompatibility complex)主要组织相容性复合体,在人类中也称为 HLA,是在体内有核细胞上表达的一组多样化的细胞表面受体。它在适应性免疫应答中发挥着重要调节作用。在体内,MHC I 可以与抗原肽片段结合形成MHC I-抗原肽复合物,被T细胞受体(T cell receptor ,TCR)识别,并将其呈现于细胞表面,供T细胞识别并促发免疫应答反应。MHC I-抗原肽复合物与TCR的高度特异性结合,对适应性免疫至关重要。因此,研究MHC I-多肽复合物与TCR之间的深层关系,对于药物开发具有重要意义。
为更好支持MHC相关研究,ACROBiosystems依托成熟的蛋白天然结构设计平台和真核蛋白表达技术平台,从根本上避免原核复性工艺不稳定、复合物构象不正确等问题,同时采用重链轻链共表达策略,成功开发了一系列经流式细胞验证的高生物活性天然结构MHC-复合物,包括NY-ESO-1,WT-1,GP100,GPC3等多个靶点,覆盖单体、四聚体以及多种荧光标记类型。另外,为满足客户多样化需求,我们提供多种天然构象MHC-肽复合物的定制开发服务,您可根据具体需求,向我们提出定制申请。

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产品优势

真核表达系统,真核构象

异源二聚体共表达,更接近天然构象

单体/四聚体可供选择

可提供FITC/PE/APC/Alexa Fluor/Biotin等多种标记类型

全面的生物活性验证方法:SPR/ELISA/FACS等

专业的MHC-多肽复合物开发平台

热门定制产品列表
MHC Allele Target
HLA-A*0101 HLA-A*0201 HLA-A*0301 HLA-A*1101 HLA-A*2402  HLA-A*3303 HLA-B*1501 HLA-B*1525 HLA-B*3802 HLA-B*4601 HLA-B*0702 
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NY-ESO-1  GP-100 MSLN AFP WT1 MAGE-A1 HPV HBV HIV EBV PRAME
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分子 货号 种属 产品描述 订购/预购
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HLW-H52E6HumanHuman HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Tetramer Protein (MALS verified)

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HLA-A*0201 | B2M & HIV GagHLH-H82E8HumanBiotinylated Human HLA-A*02:01&B2M&HIV Gag (SLYNTVATL) Complex Protein (Monomer, MALS verified)

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HLD-H52H8HumanHuman HLA-A*11:01&B2M&KRASG12D (VVGADGVGK) Tetramer Protein

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HLD-HA2H7HumanAlexa Fluor 488-Labeled Human HLA-A*11:01&B2M&KRAS (VVGAGGVGK) Complex ProteinStar Staining (Monomer)

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HLV-H52H3HumanHuman HLA-A*11:01&B2M&KRASG12V (VVGAVGVGK) Complex Protein (Monomer, MALS verified)

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验证数据

高生物活性经流式验证

经流式细胞水平验证,ACROBiosystems 开发的HLA-A*02:01&B2M&NY-ESO-1四聚体产品,可很好的与TCR结合,且活性明显高于竞品
Biotinylated Human HLA-A*02:01 NY-ESO-1 高亲和力经SPR验证

2e5 of NY-ESO-1 TCR-HEK293 cells (pool) were stained with PE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) tetramer Protein(Fig B)and negative control protein respectively (Fig. A), and competitor-M represented competitor protein (Fig. C). PE signal was used to evaluate the binding activity

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高亲和力经SPR验证

Biotinylated Human HLA-A*02:01 NY-ESO-1 高亲和力经SPR验证

Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Biotinylated Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Complex Protein (Cat. No. HL1-H82E6) with an affinity constant of 16.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).

申请 Protocol

Human HLA-A*02:01 NY-ESO-1 高亲和力经SPR验证

Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Tetramer Protein (Cat. No. HL1-H52E8) with an affinity constant of 1.35 nM as determined in a SPR assay (Biacore 8K) (QC tested).

申请 Protocol

Biotinylated Human HLA-C*07:02:01 & B2M & RYR高亲和力经SPR验证

Biotinylated Human HLA-C*07:02:01 & B2M & RYR ,His,Avitag™&Tag Free (Cat. No. HLR-H52W2) immobilized on SA Chip can bind Human KIR2DL3, Fc Tag (Cat. No. KI3-H5258) with an affinity constant of 2.40 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

申请 Protocol

Biotinylated Human HLA-C*07:02:01 & B2M & RYR高亲和力经SPR验证

Biotinylated Human HLA-C*07:02:01 & B2M & RYR ,His,Avitag™&Tag Free (Cat. No. HLR-H52W2) immobilized on SA Chip can bind Human KIR2DL2, Fc Tag (Cat. No. KI2-H5255) with an affinity constant of 1.01 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

申请 Protocol

高生物活性经ELISA验证

Biotinylated Human HLA-A*02:01 NY-ESO-1(SLLMWITQC)高生物活性经ELISA验证

Immobilized Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQC) Complex Protein (Cat. No. HL1-H82E6) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-NY-ESO-1 Antibody, Human IgG1 with a linear range of 0.1-8 ng/mL (QC tested).

申请 Protocol

Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQV)  高生物活性经ELISA验证

Immobilized Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQV) Complex Protein (Cat. No. HL1-H82E4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-NY-ESO-1 Antibody, Human IgG1 with a linear range of 0.2-16 ng/mL (QC tested).

申请 Protocol

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参考文献:

  • 1.Thomas C, Tampé R. MHC I assembly and peptide editing - chaperones, clients, and molecular plasticity in immunity. Curr Opin Immunol. 2021 Jun;70:48-56. doi: 10.1016/j.coi.2021.02.004. Epub 2021 Mar 6. PMID: 33689959.

  • 2.Becar M, Kasi A. Physiology, MHC Class I. 2021 Sep 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 32310482.

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