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MHC-多肽复合物定制服务

MHC-多肽复合物定制服务
背景
MHC(major histocompatibility complex)主要组织相容性复合体,在人类中也称为 HLA,是在体内有核细胞上表达的一组多样化的细胞表面受体。它在适应性免疫应答中发挥着重要调节作用。在体内,MHC I 可以与抗原肽片段结合形成MHC I-抗原肽复合物,被T细胞受体(T cell receptor ,TCR)识别,并将其呈现于细胞表面,供T细胞识别并促发免疫应答反应。MHC I-抗原肽复合物与TCR的高度特异性结合,对适应性免疫至关重要。因此,研究MHC I-多肽复合物与TCR之间的深层关系,对于药物开发具有重要意义。
为支持MHC相关研究,ACROBiosystems开发了一系列具有天然构象的MHC I-多肽复合物蛋白,覆盖NY-ESO-1,WT-1,GP100,GPC3等多个靶点,包括单体、四聚体、荧光标记四聚体等多种类型,可用于免疫、抗体筛选、TCR检测以及亲和力研究等多个应用场景。另外,为满足客户的多样化需求,我们可专门提供MHC I-多肽复合物定制服务,全面加速您的药物研发进程。

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产品优势

真核表达系统

单体/四聚体可供选择

可提供FITC/PE/APC/Biotin等多种标记类型

全面的生物活性验证方法:SPR/ELISA/FACS等

专业的MHC I-多肽复合物开发平台

热门定制产品列表
MHC Allele Target
HLA-A*0101 HLA-A*0201 HLA-A*0301 HLA-A*1101 HLA-A*2402  HLA-A*3303 HLA-B*1501 HLA-B*1525 HLA-B*3802 HLA-B*4601 HLA-B*0702 
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NY-ESO-1  GP-100 MSLN AFP WT1 MAGE-A1 HPV HBV HIV EBV PRAME
……
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分子 货号 种属 产品描述 订购/预购
HLA-A*11:01 & B2M HLM-H82W5 Human Biotinylated Human HLA-A*1101&B2M Complex Protein (Peptide free, MALS verified)

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HLA-A*02:01 & B2M & NY-ESO-1 HL1-H52E7 Human Human HLA-A*02:01 NY-ESO-1 (SLLMWITQV) Tetramer Protein (MALS verified)

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HL1-H52E8 Human Human HLA-A*02:01 NY-ESO-1 (SLLMWITQC) Tetramer Protein (MALS verified)

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HL1-H82E4 Human Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQV) Complex Protein (Monomer, MALS verified)

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HL1-H82E6 Human Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQC) Complex Protein (Monomer, MALS verified)

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HLA-C*07:02:01 & B2M & RYR HLR-H52W2 Human Biotinylated Human HLA-C*07:02:01 & B2M & RYR Protein,His,Avitag™&Tag Free

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HLA-A*02:01 & B2M & WT-1 HLW-H52E6 Human Human HLA-A*0201 WT-1 (RMFPNAPYL) Tetramer Protein (MALS verified)

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HLW-H82E5 Human Biotinylated Human HLA-A*0201 WT-1 (RMFPNAPYL) Complex Protein (Monomer, MALS verified)

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HLA-A*02:01 & B2M & GP100 HLG-H82E6 Human Biotinylated Human HLA-A*0201 GP100 (YLEPGPVTA) Complex Protein (Monomer, MALS verified)

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HLA-A*02:01 & B2M & Glycipan 3 HLG-H52E5 Human Human HLA-A*0201 Glycipan 3 (FVGEFFTDV) Tetramer Protein (MALS verified)

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HLG-H82E4 Human Biotinylated Human HLA-A*0201 Glycipan 3 (FVGEFFTDV) Complex Protein (Monomer, MALS verified)

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验证数据

高亲和力经SPR验证

Biotinylated Human HLA-A*02:01 NY-ESO-1 高亲和力经SPR验证

Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Biotinylated Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Complex Protein (Cat. No. HL1-H82E6) with an affinity constant of 16.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).

申请 Protocol

Human HLA-A*02:01 NY-ESO-1 高亲和力经SPR验证

Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Tetramer Protein (Cat. No. HL1-H52E8) with an affinity constant of 1.35 nM as determined in a SPR assay (Biacore 8K) (QC tested).

申请 Protocol

Biotinylated Human HLA-C*07:02:01 & B2M & RYR高亲和力经SPR验证

Biotinylated Human HLA-C*07:02:01 & B2M & RYR ,His,Avitag™&Tag Free (Cat. No. HLR-H52W2) immobilized on SA Chip can bind Human KIR2DL3, Fc Tag (Cat. No. KI3-H5258) with an affinity constant of 2.40 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

申请 Protocol

Biotinylated Human HLA-C*07:02:01 & B2M & RYR高亲和力经SPR验证

Biotinylated Human HLA-C*07:02:01 & B2M & RYR ,His,Avitag™&Tag Free (Cat. No. HLR-H52W2) immobilized on SA Chip can bind Human KIR2DL2, Fc Tag (Cat. No. KI2-H5255) with an affinity constant of 1.01 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

申请 Protocol

高生物活性经ELISA验证

Biotinylated Human HLA-A*02:01 NY-ESO-1(SLLMWITQC)高生物活性经ELISA验证

Immobilized Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQC) Complex Protein (Cat. No. HL1-H82E6) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-NY-ESO-1 Antibody, Human IgG1 with a linear range of 0.1-8 ng/mL (QC tested).

申请 Protocol

Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQV)  高生物活性经ELISA验证

Immobilized Biotinylated Human HLA-A*02:01 NY-ESO-1 (SLLMWITQV) Complex Protein (Cat. No. HL1-H82E4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-NY-ESO-1 Antibody, Human IgG1 with a linear range of 0.2-16 ng/mL (QC tested).

申请 Protocol

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参考文献:

  • 1.Thomas C, Tampé R. MHC I assembly and peptide editing - chaperones, clients, and molecular plasticity in immunity. Curr Opin Immunol. 2021 Jun;70:48-56. doi: 10.1016/j.coi.2021.02.004. Epub 2021 Mar 6. PMID: 33689959.

  • 2.Becar M, Kasi A. Physiology, MHC Class I. 2021 Sep 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 32310482.

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