真核表达系统，真核构象
异源二聚体共表达，更接近天然构象
单体/四聚体可供选择
可提供FITC/PE/APC/Alexa Fluor/Biotin等多种标记类型
全面的生物活性验证方法：SPR/ELISA/FACS等
专业的MHC-多肽复合物开发平台
| MHC Allele | Target | |
|---|---|---|
| HLA-A*0101 HLA-A*0201 HLA-A*0301 HLA-A*1101 HLA-A*2402 HLA-A*3303 HLA-B*1501 HLA-B*1525 HLA-B*3802 HLA-B*4601 HLA-B*0702 …… |
NY-ESO-1 GP-100 MSLN AFP WT1 MAGE-A1 HPV HBV HIV EBV PRAME …… |
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| 分子 | 货号 | 种属 | 产品描述 | 订购/预购 |
|---|---|---|---|---|
| HLA-A*0201 | B2M | HLM-H52H5 | Human | Human HLA-A*02:01&B2M Complex Protein (Peptide free, MALS verified) | |
| HLA-A*0301 & B2M | HLM-H82W6 | Human | Biotinylated Human HLA-A*03:01&B2M Complex Protein (Peptide free, MALS verified) | |
| HLA-A*1101 & B2M | HLM-H52H7 | Human | Human HLA-A*11:01&B2M Complex Protein (Peptide free, MALS verified) | |
| HLA-A*2402 & B2M | HLM-H82W4 | Human | Biotinylated Human HLA-A*24:02&B2M Complex Protein (Peptide free, MALS verified) | |
| HLA-C*0102 | B2M | HLM-H82E8 | Human | Biotinylated Human HLA-C*01:02&B2M Complex Protein (Peptide free) | |
| HLA-C*0303 | B2M | HLM-H82E9 | Human | Biotinylated Human HLA-C*03:03&B2M Complex Protein (Peptide free) | |
| HLA-A*02:01 & B2M | HLM-H82W3 | Human | Biotinylated Human HLA-A*02:01&B2M Complex Protein (Peptide free, MALS verified) | |
| HLA-A*11:01 & B2M | HLM-H82W5 | Human | Biotinylated Human HLA-A*11:01&B2M Complex Protein (Peptide free, MALS verified) | |
| HLA-A*0201 | B2M | EW | HLE-H82E4 | Human | Biotinylated Human HLA-A*02:01&B2M&EW (QLQNPSYDK) Complex Protein (Monomer) | |
| HLA-A*0201 | B2M | AFP | HLA-H82E3 | Human | Biotinylated Human HLA-A*02:01&B2M&AFP (FMNKFIYEI) Complex Protein (Monomer, MALS verified) | |
| HLA-A*0201 | B2M | HBV | HLT-H82E7 | Human | Biotinylated Human HLA-A*02:01&B2M&HBV (FLLTKILTI) Complex Protein (Monomer, MALS verified) | |
| HLT-H82E9 | Human | Biotinylated Human HLA-A*02:01&B2M&HBV (FLLTRILTI) Complex Protein (Monomer, MALS verified) | ||
| HLA-A*02:01 & B2M & WT-1 | HLW-H82E5 | Human | Biotinylated Human HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Complex Protein (Monomer, MALS verified) | |
| HLW-H52E6 | Human | Human HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Tetramer Protein (MALS verified) | ||
| HLA-A*02:01 & B2M & GP100 | HLG-H82E6 | Human | Biotinylated Human HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Complex Protein (Monomer, MALS verified) | |
| HLA-A*0201 | B2M & HIV Gag | HLH-H82E8 | Human | Biotinylated Human HLA-A*02:01&B2M&HIV Gag (SLYNTVATL) Complex Protein (Monomer, MALS verified) | |
| HLA-A*0201 | B2M | MAGE-A1 | HLM-H82E1 | Human | Biotinylated Human HLA-A*02:01&B2M&MAGE-A1 (KVLEYVIKV) Complex Protein (Monomer, MALS verified) | |
| HLA-A*0201 | B2M | MAGE-A2 | HLM-H82E6 | Human | Biotinylated Human HLA-A*02:01&B2M&MAGE-A2 (YLQLVFGIEV) Complex Protein (Monomer, MALS verified) | |
| HLA-A*0201 | B2M | MAGE-A3 | HLM-H82E3 | Human | Biotinylated Human HLA-A*02:01&B2M&MAGE-A3 (KVAELVHFL) Complex Protein (Monomer, MALS verified) | |
| HLA-A*0201 | B2M | MAGE-A4 | HLM-H82E5 | Human | Biotinylated Human HLA-A*02:01&B2M&MAGE-A4 (GVYDGREHTV) Complex Protein (Monomer, MALS verified) | |
| HLA-C*07:02:01 & B2M & RYR | HLR-H52W2 | Human | Biotinylated Human HLA-C*07:02:01&B2M&RYR (RYRPGTVAL) Complex Protein (Monomer) | |
| HLA-A*0201 | B2M & CMV pp65 | HLC-H82E4 | Human | Biotinylated Human HLA-A*02:01&B2M&CMV pp65 (NLVPMVATV) Complex Protein (Monomer, MALS verified) | |
| HLA-A*0201 | B2M | HPV16-E6 | HLH-HP2H7 | Human | PE-Labeled Human HLA-A*02:01&B2M&HPV16-E6 (TIHDIILECV) Tetramer Protein | |
| HLA-A*0201 | B2M | NY-ESO-1 | HL1-HP2E5 | Human | PE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein | |
| HL1-HP2E6 | Human | PE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein | ||
| HLA-A*0201 | B2M | RHAMM-R3 | HLR-H82E6 | Human | Biotinylated Human HLA-A*02:01&B2M&RHAMM-R3 (ILSLELMKL) Complex Protein (Monomer, MALS verified) | |
| HLA-A*02:01 & B2M & NY-ESO-1 | HL1-H82E4 | Human | Biotinylated Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Complex Protein (Monomer, MALS verified) | |
| HL1-H82E6 | Human | Biotinylated Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Complex Protein (Monomer, MALS verified) | ||
| HL1-H52E7 | Human | Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein (MALS verified) | ||
| HL1-H52E8 | Human | Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein (MALS verified) | ||
| HLA-A*02:01 & B2M & Glycipan 3 | HLG-H82E4 | Human | Biotinylated Human HLA-A*02:01&B2M&Glycipan 3 (FVGEFFTDV) Complex Protein (Monomer, MALS verified) | |
| HLG-H52E5 | Human | Human HLA-A*02:01&B2M&Glycipan 3 (FVGEFFTDV) Tetramer Protein (MALS verified) | ||
| HLA-A*0301 & B2M & KRAS (VVGAGGVGK) | HLS-H82E5 | Human | Biotinylated Human HLA-A*03:01&B2M&KRAS (VVGAGGVGK) Complex Protein (Monomer) | |
| HLS-H52H4 | Human | Human HLA-A*03:01&B2M&KRAS (VVGAGGVGK) Complex Protein (Monomer) | ||
| HLA-A*1101 | B2M | KRAS (VVGAGGVGK) | HLS-H82E3 | Human | Biotinylated Human HLA-A*11:01&B2M&KRAS (VVGAGGVGK) Complex Protein (Monomer, MALS verified) | |
| HLS-H52H5 | Human | Human HLA-A*11:01&B2M&KRAS (VVGAGGVGK) Complex Protein (Monomer, MALS verified) | ||
| HLS-HA2H9 | Human | Alexa Fluor 647-Labeled Human HLA-A*11:01&B2M&KRAS (VVGAGGVGK) Complex ProteinStar Staining (Monomer) | ||
| HLA-A*0201 | B2M & MAGE-A4 (KVLEHVVRV) | HLP-H82E5 | Human | Biotinylated Human HLA-A*02:01&B2M&MAGE-A4 (KVLEHVVRV) Complex Protein (Monomer, MALS verified) | |
| HLA-A*02:01 & B2M & MAGE-A4 (KVLEHVVRV) | HLK-H52E5 | Human | Human HLA-A*02:01&B2M&MAGE-A4 (KVLEHVVRV) Tetramer Protein (MALS verified) | |
| HLA-A*0301 & B2M & KRASG12C (VVGACGVGK) | HLC-H82E6 | Human | Biotinylated Human HLA-A*03:01&B2M&KRASG12C (VVGACGVGK) Complex Protein (Monomer) | |
| HLC-H52H4 | Human | Human HLA-A*03:01&B2M&KRASG12C (VVGACGVGK) Complex Protein (Monomer) | ||
| HLC-H52H7 | Human | Human HLA-A*03:01&B2M&KRASG12C (VVGACGVGK) Tetramer Protein | ||
| HLA-A*1101 | B2M | KRASG12D (VVGADGVGK) | HLD-H82E5 | Human | Biotinylated Human HLA-A*11:01&B2M&KRASG12D (VVGADGVGK) Complex Protein (Monomer, MALS verified) | |
| HLD-H52H4 | Human | Human HLA-A*11:01&B2M&KRASG12D (VVGADGVGK) Complex Protein (Monomer, MALS verified) | ||
| HLD-H52H8 | Human | Human HLA-A*11:01&B2M&KRASG12D (VVGADGVGK) Tetramer Protein | ||
| HLD-HA2H7 | Human | Alexa Fluor 488-Labeled Human HLA-A*11:01&B2M&KRAS (VVGAGGVGK) Complex ProteinStar Staining (Monomer) | ||
| HLA-A*1101 | B2M | KRASG12V (VVGAVGVGK) | HLV-H82E6 | Human | Biotinylated Human HLA-A*11:01&B2M&KRASG12V (VVGAVGVGK) Complex Protein (Monomer, MALS verified) | |
| HLV-H52H3 | Human | Human HLA-A*11:01&B2M&KRASG12V (VVGAVGVGK) Complex Protein (Monomer, MALS verified) | ||
| HLV-H52H8 | Human | Human HLA-A*11:01&B2M&KRASG12V (VVGAVGVGK) Tetramer Protein |
2e5 of NY-ESO-1 TCR-HEK293 cells (pool) were stained with PE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) tetramer Protein（Fig B）and negative control protein respectively (Fig. A), and competitor-M represented competitor protein (Fig. C). PE signal was used to evaluate the binding activity
Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Biotinylated Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Complex Protein (Cat. No. HL1-H82E6) with an affinity constant of 16.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).
申请 Protocol
Anti-NY-ESO-1 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human HLA-A0201 NY-ESO-1 (SLLMWITQC) Tetramer Protein (Cat. No. HL1-H52E8) with an affinity constant of 1.35 nM as determined in a SPR assay (Biacore 8K) (QC tested).
申请 Protocol
1.Thomas C, Tampé R. MHC I assembly and peptide editing - chaperones, clients, and molecular plasticity in immunity. Curr Opin Immunol. 2021 Jun;70:48-56. doi: 10.1016/j.coi.2021.02.004. Epub 2021 Mar 6. PMID: 33689959.
2.Becar M, Kasi A. Physiology, MHC Class I. 2021 Sep 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 32310482.
膜杰作
Star Staining
Aneuro
ComboX
ActiveMax
GENPower
ClinMax
Star Ribbon
