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Alpha-Synuclein信息
英文名称：Synuclein alpha
中文名称：α-突触核蛋白
靶点别称：Truncated Alpha Synuclein，Α-Synuclein，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，α-Synuclein，PARK4，PD1，alpha-Synuclein，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，Non A-Beta Component Of AD Amyloid，PARK1，SNCA，Synuclein Alpha，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor
中文名称：α-突触核蛋白
靶点别称：Truncated Alpha Synuclein，Α-Synuclein，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，α-Synuclein，PARK4，PD1，alpha-Synuclein，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，Non A-Beta Component Of AD Amyloid，PARK1，SNCA，Synuclein Alpha，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor
上市药物数量：0
临床药物数量：12
最高研发阶段：临床二期
临床药物数量：12
最高研发阶段：临床二期
Alpha-Synuclein产品列表
产品库
属性
评论(1)
ALN-C52H5|Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)
- 136XXXXXXX5
- 老顾客了 希望能一直保持好质量 每次实验都能得到很好的结果 核蛋白活性数据很好 纯度也很让我们满意 做实验首选我们会继续选这家
- 2022-08-17
0人赞
Alpha-Synuclein 分子别名
SNCA,NACP,PARK1,alpha-Synuclein
Alpha-Synuclein 分子背景
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
Alpha-Synuclein 前沿进展
Alpha-Synuclein临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| Syneuro (Indus Biotech) | 临床阶段不明 | Indus Biotech Pvt Ltd | 帕金森病 | 详情 | |
| [18F]UCB-2897 | 临床一期 | 帕金森综合征, 多系统萎缩 | 详情 | ||
| Affitope-PD03 (AFFiRiS) | PD-03A; AFFITOPE-PD03A | Affiris | 详情 | ||
| Exidavnemab | PD-0805; BAN-0805; BBV-0805; ABBV-0805; PR-1808164 | 艾伯维 | 详情 | ||
| UCB-0599 | UCB-1332; NPT200-11; UCB-0599 | Neuropore Therapies, Novartis Ag | 详情 | ||
| UB-312 | UB-312 | United Neuroscience | 详情 | ||
| Affitope-PD01 | PD-01A; Affitope-PD01; Affitope-PD01A; PD-01 (AFFiRiS) | Affiris | 详情 | ||
| Kenterin | ENT-01; kenterin; Enterin-01 | Enterin | 详情 | ||
| NPT-189 | NPT-189 | Proclara Biosciences | 详情 | ||
| Buntanetap | ANVS-405; ANVS-401 | 临床一期 | Raptor Pharmaceutical | 唐氏综合征, 慢性创伤性脑病, 额颞痴呆 | 详情 |
| MEDI-1341 | MEDI-1341; TAK- 341 | 阿斯利康制药有限公司, Takeda Pharmaceutical Co Ltd | 详情 | ||
| ACI-7104 | ACI-7104 | 临床一期 | Ac Immune Sa | 帕金森病 | 详情 |
| UCB-7853 | UCB-7853 | 临床一期 | Ucb Biopharma Srl | 帕金森病 | 详情 |
| PBT-434 | PBT-434; ATH-434 | 临床二期 | Prana Biotechnology | 多系统萎缩 | 详情 |
| Prasinezumab | PRX-002; RG-7935; NEOD-002; RO-7046015 | 临床二期 | Prothena | 帕金森病 | 详情 |
| Lu AF-82422 (Lundbeck A/S) | Lu AF-82422; Lu AF82422; Lu-AF82422 | 临床二期 | 灵北制药, Genmab | 帕金森病, 多系统萎缩 | 详情 |
| ION-464 | BIIB-101; IONIS-BIIB6 Rx; ION-464 | 临床一期 | Ionis Pharmaceuticals Inc | 多系统萎缩 | 详情 |
| Emrusolmin | Anle-138b | 临床一期 | Modag Gmbh | 帕金森病 | 详情 |
