Alpha-Synuclein 靶点蛋白|抗体药物|临床药物信息

Alpha-Synuclein信息

英文名称：Synuclein alpha
中文名称：α-突触核蛋白
靶点别称：Truncated Alpha Synuclein，Α-Synuclein，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，Î±-Synuclein，PARK4，PD1，alpha-Synuclein，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，Non A-Beta Component Of AD Amyloid，PARK1，SNCA，Synuclein Alpha，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor

上市药物数量：0
临床药物数量：12
最高研发阶段：临床二期

Alpha-Synuclein产品列表

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Protein (9)

标记

货号	物种	产品描述
ALN-H52H8	Human	Human Alpha-Synuclein Protein, His Tag
ALN-H82H8	Human	Biotinylated Human Alpha-Synuclein Protein, His,Avitag™
ALN-H5253	Human	Human Alpha-Synuclein Protein, Fc Tag (MALS verified)
ALN-C52H5	Cynomolgus	Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)
ALN-M52H6	Mouse	Mouse Alpha-Synuclein Protein, His Tag (MALS verified)
ALN-H5214	Human	Human Alpha-Synuclein Protein, Tag Free (MALS verified)
ALN-H51H5	Human	Human Alpha-Synuclein (A53T) Protein, His Tag
ALN-H5116	Human	Human Alpha-Synuclein (A53T) Protein, Tag Free (MALS verified)
ALN-H5117	Human	Human Alpha-Synuclein (E46K) Protein, Tag Free (MALS verified)

ALN-C52H5|Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)

136XXXXXXX5

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老顾客了希望能一直保持好质量每次实验都能得到很好的结果核蛋白活性数据很好纯度也很让我们满意做实验首选我们会继续选这家
2022-08-17

Alpha-Synuclein 分子别名

SNCA,NACP,PARK1,alpha-Synuclein

Alpha-Synuclein 分子背景

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

Alpha-Synuclein 前沿进展

Alpha-Synuclein临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Syneuro (Indus Biotech)		临床阶段不明	Indus Biotech Pvt Ltd	帕金森病	详情
[18F]UCB-2897		临床一期		帕金森综合征, 多系统萎缩	详情
Affitope-PD03 (AFFiRiS)	PD-03A; AFFITOPE-PD03A		Affiris		详情
Exidavnemab	PD-0805; BAN-0805; BBV-0805; ABBV-0805; PR-1808164		艾伯维		详情
UCB-0599	UCB-1332; NPT200-11; UCB-0599		Neuropore Therapies, Novartis Ag		详情
UB-312	UB-312		United Neuroscience		详情
Affitope-PD01	PD-01A; Affitope-PD01; Affitope-PD01A; PD-01 (AFFiRiS)		Affiris		详情
Kenterin	ENT-01; kenterin; Enterin-01		Enterin		详情
NPT-189	NPT-189		Proclara Biosciences		详情
Buntanetap	ANVS-405; ANVS-401	临床一期	Raptor Pharmaceutical	唐氏综合征, 慢性创伤性脑病, 额颞痴呆	详情
MEDI-1341	MEDI-1341; TAK- 341		阿斯利康制药有限公司, Takeda Pharmaceutical Co Ltd		详情
ACI-7104	ACI-7104	临床一期	Ac Immune Sa	帕金森病	详情
UCB-7853	UCB-7853	临床一期	Ucb Biopharma Srl	帕金森病	详情
PBT-434	PBT-434; ATH-434	临床二期	Prana Biotechnology	多系统萎缩	详情
Prasinezumab	PRX-002; RG-7935; NEOD-002; RO-7046015	临床二期	Prothena	帕金森病	详情
Lu AF-82422 (Lundbeck A/S)	Lu AF-82422; Lu AF82422; Lu-AF82422	临床二期	灵北制药, Genmab	帕金森病, 多系统萎缩	详情
ION-464	BIIB-101; IONIS-BIIB6 Rx; ION-464	临床一期	Ionis Pharmaceuticals Inc	多系统萎缩	详情
Emrusolmin	Anle-138b	临床一期	Modag Gmbh	帕金森病	详情

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Alpha-Synuclein