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 > 【Alpha-Synuclein】

Alpha-Synuclein信息

英文名称:Synuclein alpha
中文名称:α-突触核蛋白
靶点别称:Truncated Alpha Synuclein,Α-Synuclein,Non-A Beta Component Of AD Amyloid,Synuclein Alpha-140,I+/--Synuclein,α-Synuclein,PARK4,PD1,alpha-Synuclein,Synuclein, Alpha (Non A4 Component Of Amyloid Precursor),Non A-Beta Component Of AD Amyloid,PARK1,SNCA,Synuclein Alpha,NACP,Parkinson Disease (Autosomal Dominant, Lewy Body) 4,Non-A4 Component Of Amyloid Precursor,Non A4 Component Of Amyloid Precursor
上市药物数量:0
临床药物数量:12
最高研发阶段:临床二期

Alpha-Synuclein产品列表

 
评论(1)
ALN-C52H5|Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)
  1. 136XXXXXXX5
  2. 0人赞
  3. 老顾客了 希望能一直保持好质量 每次实验都能得到很好的结果 核蛋白活性数据很好 纯度也很让我们满意 做实验首选我们会继续选这家
  4. 2022-08-17
 

Alpha-Synuclein 分子别名

SNCA,NACP,PARK1,alpha-Synuclein

Alpha-Synuclein 分子背景

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

Alpha-Synuclein 前沿进展

Alpha-Synuclein临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Syneuro (Indus Biotech) 临床阶段不明 Indus Biotech Pvt Ltd 帕金森病 详情
[18F]UCB-2897 临床一期 帕金森综合征, 多系统萎缩 详情
Affitope-PD03 (AFFiRiS) PD-03A; AFFITOPE-PD03A Affiris 详情
Exidavnemab PD-0805; BAN-0805; BBV-0805; ABBV-0805; PR-1808164 艾伯维 详情
UCB-0599 UCB-1332; NPT200-11; UCB-0599 Neuropore Therapies, Novartis Ag 详情
UB-312 UB-312 United Neuroscience 详情
Affitope-PD01 PD-01A; Affitope-PD01; Affitope-PD01A; PD-01 (AFFiRiS) Affiris 详情
Kenterin ENT-01; kenterin; Enterin-01 Enterin 详情
NPT-189 NPT-189 Proclara Biosciences 详情
Buntanetap ANVS-405; ANVS-401 临床一期 Raptor Pharmaceutical 唐氏综合征, 慢性创伤性脑病, 额颞痴呆 详情
MEDI-1341 MEDI-1341; TAK- 341 阿斯利康制药有限公司, Takeda Pharmaceutical Co Ltd 详情
ACI-7104 ACI-7104 临床一期 Ac Immune Sa 帕金森病 详情
UCB-7853 UCB-7853 临床一期 Ucb Biopharma Srl 帕金森病 详情
PBT-434 PBT-434; ATH-434 临床二期 Prana Biotechnology 多系统萎缩 详情
Prasinezumab PRX-002; RG-7935; NEOD-002; RO-7046015 临床二期 Prothena 帕金森病 详情
Lu AF-82422 (Lundbeck A/S) Lu AF-82422; Lu AF82422; Lu-AF82422 临床二期 灵北制药, Genmab 帕金森病, 多系统萎缩 详情
ION-464 BIIB-101; IONIS-BIIB6 Rx; ION-464 临床一期 Ionis Pharmaceuticals Inc 多系统萎缩 详情
Emrusolmin Anle-138b 临床一期 Modag Gmbh 帕金森病 详情

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