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新冠疫苗研发核心工具

2019年12月,一种新型的冠状病毒SARS-CoV-2开始在全球范围内快速传播,造成了全球性的新冠疫情大流行,导致(截止到2021年11月)超过2亿人确诊感染新型冠状病毒,近500万人死亡,给全球人民的生命健康带来巨大威胁的同时,对世界各国的社会稳定和经济发展造成了深远的影响。
不仅如此,在新冠疫情肆虐全球的过程中,不断出现的新冠病毒变异毒株更是使得挑战升级。目前,世界卫生组织(WHO)已将具有更强传播能力或免疫逃逸能力的4种变异毒株列为“需要特别关注的突变毒株”(VOCs),包括Alpha(B.1.1.7)、Beta(B.1.351)、Gamma(P.1)及Delta(B.1.617.2)。其中,Beta和Gamma毒株具有极强的免疫逃逸能力,而Alpha和Delta变异毒株具有极强的传播能力和较强的免疫逃逸能力。目前,在Delta变异毒株逐渐成为全球主要流行毒株的同时,如Lambda(C.37)、Mu(B.1.621)、C.1.2的新型变异毒株也不断涌现。

>>> 点击查看新冠突变抗原蛋白及相关产品

面对来势汹汹的新冠疫情,疫苗作为防控传染病最有效且最经济的公共健康措施之一, 开发可高效预防新型冠状病毒感染及传播的疫苗并持续评估其对流行突变株的有效性具有重要意义。
新冠疫苗研发技术路线
在疫情爆发后仅1年多的时间里,全球各科研单位和疫苗公司紧密合作、共同努力,成功研制出包括灭活病毒疫苗、重组蛋白疫苗、腺病毒载体疫苗、mRNA疫苗等多款新冠疫苗并获得紧急使用授权,在全球范围内进行接种。另据不完全统计,目前全球共有300余种新冠候选疫苗处于临床前及临床阶段试验,接下来仍将有多种新冠疫苗获批使用。
新冠疫苗技术路线
新冠疫苗研发生产和临床的法规要求
国家药品监督管理局药品审评中心于2020年8月发布了一系列《新型冠状病毒预防用疫苗研发技术指导原则(试行)》,从药学研究、非临床研究到临床研究全流程,明确了灭活疫苗、基因工程重组疫苗、病毒载体类疫苗、DNA疫苗及mRNA疫苗等不同技术路线评价过程中的关键指标。
新冠疫苗开发流程
生产/质量控制

(1)疫苗抗原含量检测

灭活疫苗/重组蛋白疫苗:SDS-PAGE,MS,ELISA;

病毒载体疫苗/核酸疫苗:Western Blot,FACS;

(2)疫苗抗原活性检测

重组蛋白疫苗:ELISA,SPR,BLI

(3)疫苗生物效价检测

动物血清总抗体检测:间接法ELISA

临床前药效学研究

(1)疫苗生物效价研究

①体内效力试验:

★体液免疫:

Ⅰ动物血清总抗体检测:间接法ELISA

Ⅱ动物血清中和抗体检测:cVNT,pVNT,sVNT(竞争法ELISA)

★细胞免疫:Elispot

②体外效价检测: 疫苗抗原含量:双抗夹心ELISA

③动物保护性试验:动物攻毒保护试验

(2)毒理研究

①体液免疫(抗体亚型检测):间接法ELISA

②细胞免疫(特异性T细胞及细胞因子检测):Elispot

早期临床试验(I-II期)
关键性注册临床试验(III期)

(1)疫苗生物效价研究

①体内效力试验:

★体液免疫:

Ⅰ人体血清总抗体检测:间接法ELISA

Ⅱ人体血清中和抗体检测:cVNT,pVNT,sVNT(竞争法ELISA)

★细胞免疫:Elispot

②体外效价检测:

★疫苗抗原含量:双抗夹心法ELISA

③动物保护性试验:动物攻毒保护试验

(2)毒理研究

①体液免疫(抗体亚型检测):间接法ELISA

②细胞免疫(特异性T细胞及细胞因子检测):Elispot

(3) 免疫持久性 (III期临床试验)

①人体血清总抗体检测:间接法ELISA

②人体血清中和抗体检测:CVNT, pVNT, sVNT(竞争法ELISA)

>>> 点击下载《新型冠状病毒预防用疫苗研发技术指导原则(试行)》系列指导原则

疫苗研发与临床及临床前研究解决方案
为助力新冠疫苗研发,加速疫苗上市进程,ACROBiosystems(百普赛斯)持续关注新冠疫情发展,开发了针对新冠野生型及Alpha (B.1.1.7)、Beta (B.1.351)、Gamma (P.1)、Delta (B.1.617.2)、Lambda (C.37)、Mu (B.1.621)等VOCs及VOIs流行突变株的系列相关产品,提供高纯度高稳定性的抗原、高活性广谱抗体、突变特异性ELISA试剂盒及高效便捷的预偶联磁珠产品,力求为新冠疫苗研发到上市前的全流程提供相应解决方案。
疫苗抗原含量检测
  • 天然Pre-fusion状态三聚体Spike蛋白
  • RBD/S trimer抗原定量检测试剂盒
  • 突变特异性抗体

SDS-PAGE及MS抗原检测的高纯度标品——天然Pre-fusion状态三聚体Spike蛋白

引入6P突变使Spike蛋白稳定在融合前构象,接近蛋白天然构象
经SDS-PAGE和SEC-MALS及负染电镜技术验证,Spike三聚体纯度>90%
提供所有VOCs及其他热门突变株产品,突变位点与真实毒株一致
产品列表
新冠种属 货号 突变位点 标签 订购/预购
Omicron | BQ.1.1.10 SPN-C524m T19I, LPP24-26del, A27S, HV69-70del, G142D, Y144del, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

预购

Omicron | BQ.1.1.11 SPN-C524l T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, S494P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

预购

Omicron | BN.1 SPN-C524b T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

预购

Omicron | CH.1.1 SPN-C5249 T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

预购

Omicron | XBB SPN-C5248 T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

预购

SPN-C82Ew T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag & Avi Tag

预购

Omicron | BQ.1 SPN-C524a T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

预购

Omicron | BJ.1 SPN-C522u T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, S477N, T478K, V483A, E484A, F490V, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, G798D, Q954H, N969K, S1003I, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

Omicron | XBB.1 SPN-C522t T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

Omicron | BQ.1.1 SPN-C522s T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

SPN-C82Ey T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag & Avi Tag

预购

Omicron | BA.2.75.2 SPN-C522r T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

SPN-C82Ex T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag & Avi Tag

预购

Omicron | BF.7 SPN-C522q T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

SPN-C82Ev T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag & Avi Tag

预购

Omicron | BA.5.5 SPN-C522p T19I, LPP24-26del, A27S, HV69-70del, T76I, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

Omicron | BA.2.3.20 SPN-C522n T19I, LPP24-26del, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

Omicron | BA.4.6 SPN-C522m T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

Omicron | BA.2.75 SPN-C522f T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

Omicron | BA.2.76 SPN-C522i T19I, LPP24-26del, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

Omicron | BA.2.74 SPN-C522h T19I, LPP24-26del, A27S, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452M, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

Omicron | BA.2.38 SPN-C522g T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417T, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

Omicron | BA.5 SPN-C522e T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

SPN-C82Eu T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag & Avi Tag

订购

Omicron | BA.4 SPN-C5229 T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

SPN-C82Et T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag & Avi Tag

订购

Omicron | BA.2.12.1 SPN-C522d T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452Q, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

SPN-C82Es T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452Q, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag & Avi Tag

订购

Omicron | BA.2.13 SPN-C5227 T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452M, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

XD | BA.1 x AY.4 recombinant SPN-C5226 T19R, A27S, T95I, G142D, EFR156G, NL211I, INS214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

Omicron | BA.3 SPN-C5225 A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, G339D, S371F, S373P, S375F, D405N, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

Omicron | BA.2 SPN-C5223 T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

SPN-C82Er T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag & Avi Tag

订购

Omicron | BA.1.1 SPN-C5224 A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

Omicron | B.1.1.529 SPN-C52Hz A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F His Tag

订购

SPN-C82Ee A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F His Tag & Avi Tag

订购

Delta Plus | AY.4.2 SPN-C52Hu T19R, T95I, Y145H, EF156-157del, R158G, A222V, L452R, T478K, D614G, P681R, D950N His Tag

订购

Delta Plus | AY.1|AY.2|AY.3 SPN-C52Ht T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N His Tag

订购

SPN-C82Ei T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N His Tag & Avi Tag

订购

Delta | B.1.617.2 SPN-C52He T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N His Tag

订购

SPN-C82Ec T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N His Tag & Avi Tag

订购

Gamma | P.1 SPN-C52Hg L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F His Tag

订购

SPN-C82E6 L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F His Tag & Avi Tag

订购

Beta | B.1.351 SPN-C52Hk L18F, D80A, D215G, LAL242-244del, R246I, K417N, E484K, N501Y, D614G, A701V His Tag

订购

SPN-C52Hm K417N, D614G His Tag

订购

SPN-C52Hp N501Y, D614G His Tag

订购

SPN-C82E4 L18F, D80A, D215G, LAL242-244del, R246I, K417N, E484K, N501Y, D614G, A701V His Tag & Avi Tag

订购

Alpha | B.1.1.7 SPN-C52H6 HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H His Tag

订购

SPN-C82E5 HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H His Tag & Avi Tag

订购

C.1.2 SPN-C52Hb C136F, Y144del, R190S, D215G, LA242-243del, Y449H, E484K, N501Y, D614G, H655Y, N679K, T716I, T859N His Tag

订购

SPN-C82Eq C136F, Y144del, R190S, D215G, LA242-243del, Y449H, E484K, N501Y, D614G, H655Y, N679K, T716I, T859N His Tag & Avi Tag

订购

Mu | B.1.621 SPN-C52Ha T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N His Tag

订购

SPN-C82Ek T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N His Tag & Avi Tag

订购

Lambda | C.37 SPN-C52Hs G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N His Tag

订购

Kappa | B.1.617.1 SPN-C52Hr T95I, G142D, E154K, L452R, E484Q, D614G, P681R His Tag

订购

B.1.620 SPN-C82Ed P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H His Tag & Avi Tag

订购

D614G SPN-C52H3 D614G His Tag

订购

SPN-C82E3 D614G His Tag & Avi Tag

订购

Wild type SPN-C52H9 His Tag

订购

SPN-C52Hd F817P, A892P, A899P, A942P, K986P, V987P His Tag

订购

SPN-C82E9 His Tag & Avi Tag

订购

验证数据
验证数据
结构鉴定数据(SDS-PAGE & SEC-MALS & 负染电镜)

The purity of SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9) is more than 90% verified by SDS-PAGE under reducing (R) condition. The molecular weight was around 550-660 kDa confirmed by SEC-MALS. The particles are similar in size and appearance to SARS-CoV-2 trimers reported in published literature verified by negative stain electron micrography.

Protocol

活性验证数据

Immobilized Anti-SARS-CoV-2 Neutralizing Antibody, Human IgG1 (Cat. No. SAD-S35) at 1 μg/mL (100 μL/well) can bind SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9) with a linear range of 0.3-10 ng/mL.

Protocol

活性验证数据

用不同的SARS-CoV-2 S protein检测康复病人血清,其中SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9)信噪比较高。

Protocol

高效获取抗原含量指标——RBD/S trimer抗原定量检测试剂盒(双抗体夹心法ELISA)

满足各种疫苗对于不同灵敏度需求的检测
试剂盒中抗体对可识别不同突变株抗原且活性不变
经客户验证,实验数据稳定,可对疫苗量产进行定量监控
产品列表
货号 产品描述 订购/预购
RAS-A010 SARS-CoV-2 Nucleocapsid Protein Titer Assay Kit

订购

RAS-A020 SARS-CoV-2 Spike Protein Titer Assay Kit

订购

RAS-A021 SARS-CoV-2 Spike RBD Titer Assay Kit

订购

RAS-A039 SARS-CoV-2 Spike Protein ELISA Kit (For Vaccine Development)

订购

RAS-A050 SARS-CoV-2 Spike RBD ELISA Kit (For Vaccine Development)

订购

RAS-A115 SARS-CoV-2 Spike Trimer (Wild Type) Specific ELISA Kit (For Vaccine Development)

订购

RAS-A116 SARS-CoV-2 Spike RBD (Wild Type) Specific ELISA Kit (For Vaccine Development)

订购

RAS-A055 SARS-CoV-2 Spike Trimer (B.1.617.2) Specific ELISA Kit (For Vaccine Development)

订购

RAS-A092 SARS-CoV-2 Spike RBD (B.1.617.2) Specific ELISA Kit (For Vaccine Development)

订购

RAS-A081 SARS-CoV-2 Spike Trimer (B.1.1.529) Specific ELISA Kit (For Vaccine Development)

订购

RAS-A082 SARS-CoV-2 Spike RBD (B.1.1.529) Specific ELISA Kit (For Vaccine Development)

订购

RAS-A111 SARS-CoV-2 Spike Trimer (BA.1) Specific ELISA Kit (High Sensitivity)

订购

RAS-A127 SARS-CoV-2 Spike Trimer (BA.2.12.1) Specific ELISA Kit

订购

RAS-A128 SARS-CoV-2 Spike RBD (BA.2.12.1) Specific ELISA Kit

订购

RAS-A129 SARS-CoV-2 Spike Trimer (BA.2.12.1) ELISA Kit

订购

RAS-A130 SARS-CoV-2 Spike RBD (BA.2.12.1) ELISA Kit

订购

RAS-A117 SARS-CoV-2 Spike RBD (BA.4 & BA.5) ELISA Kit

订购

RAS-A118 SARS-CoV-2 Spike Trimer (BA.4) ELISA Kit

订购

RAS-A124 SARS-CoV-2 Spike Trimer (BA.4) Specific ELISA Kit (For Vaccine Development)

订购

RAS-A126 SARS-CoV-2 Spike RBD (BA.4 & BA.5) Specific ELISA Kit (For Vaccine Development)

订购

RAS-A119 SARS-CoV-2 Spike Trimer (BA.5) ELISA Kit

订购

RAS-A125 SARS-CoV-2 Spike Trimer (BA.5) Specific ELISA Kit (For Vaccine Development)

订购

验证数据

试剂盒检测Spike Protein定量范围:781-3.05pg/mL

试剂盒检测Spike Protein定量范围:625-4.88ng/mL

突变抗原含量检测方法建立必备试剂——Omicron/Delta/Beta & Gamma突变特异性抗体

特异性:经ELISA验证,该抗体与只相应突变RBD抗原特异性结合,与其他野生型或突变抗原不结合
高活性:抗体与抗原结合活性经BLI/SPR验证
高纯度:抗体纯度经SDS-PAGE验证>95%,经MALS验证>90%
可用于针对Omicron变异株的二代疫苗的研发、生产质控、临床前及临床研究中的免疫原性检测实验
产品列表
货号 种属 产品描述 抗原表位 订购/预购
SPD-M305 Mouse Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1 (AS113) (Omicron Specific) Spike RBD

订购

SPD-M415 Human Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AS113) (Omicron Specific) Spike RBD

订购

SPD-M110 Mouse Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1 (AS110) (Delta Specific) (MALS verified) Spike RBD

订购

SPD-M370 Human Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM110) (Delta Specific) Spike RBD

订购

SPD-M334 Mouse Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1 (AM334) (Beta & Gamma Specific) (MALS verified) Spike RBD

订购

SPD-M416 Mouse Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1 (AS106) (Beta & Gamma Specific) Spike RBD

订购

验证数据

>经BLI检测,SPD-M305可以与Omicron突变Spike RBD (Cat.No. SPD-C522e)结合,亲和力常数为9.07 nM。

Loaded Monoclonal Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1 (Cat. No. SPD-M305) on AMC Biosensor, can bind SARS-CoV-2 Spike RBD, His Tag (B.1.1.529/Omicron) (Cat. No. SPD-C522e) with an affinity constant of 9.07 nM as determined in BLI assay (ForteBio Octet Red96e).

Protocol

>经ELISA验证,SPD-M305可以与Omicron突变Spike RBD (Cat.No. SPD-C522e)结合,线性范围0.4- 12.5ng/mL;与野生型(Cat.No. SPD-C52H1)、Alpha (Cat.No. SPD-C52Hn)、Beta(Cat.No. SPD-C52Hp)、Delta(Cat.No. SPD-C52Hh)、Gamma(Cat.No. SPD-C52Hr) 的 Spike RBD均不结合。

Immobilized  SARS-CoV-2 Spike RBD (Omicron, Cat.No. SPD-C522e) can bind Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1(Cat.No.SPD-M305) with linear range of 0.4-12.5 ng/mL. The antibody does not bind Spike RBD of WT (Cat.No. SPD-C52H1), Alpha (Cat.No. SPD-C52Hn), Beta (Cat.No. SPD-C52Hp), Delta(Cat.No. SPD-C52Hh) and Gamma (Cat.No. SPD-C52Hr).

Protocol

>>> 相关蛋白产品纯度经MALS验证,活性经体外结合实验和细胞水平验证,点击查看详情。

>>> 如果您希望ACRO开发更多类型的SARS-CoV-2(COVID-19)的产品或有定制化的产品、服务需求,请点击提议

疫苗抗原活性检测
  • 高质量ACE2受体蛋白
  • 抗原与ACE2亲和力服务

抗原活性验证天然二聚体配体——高质量ACE2受体蛋白

提供His、His, Avitag™、Fc、Fc, Avitag™等不同标签
覆盖Human、Mouse、Cynomolgus、Rat、Paguma larvata不同种属
生物素化及非生物素化受体蛋白可选择
高纯度高结合活性经验证
产品列表
分子 货号 种属 标签 宿主 产品描述 订购/预购
ACE2 AC2-H82E6 Human His Tag & Avi Tag HEK293 Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)

订购

ACE2 AC2-H82E8 Human His Tag & Avi Tag HEK293 Biotinylated Monomeric Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)

订购

ACE2 AC2-H52H8 Human His Tag HEK293 Human ACE2 / ACEH Protein, His Tag (MALS verified)

订购

ACE2 AC2-H5257 Human Fc Tag HEK293 Human ACE2 / ACEH Protein, Fc Tag (MALS verified)

订购

ACE2 AC2-H82F9 Human Fc Tag & Avi Tag HEK293 Biotinylated Human ACE2 / ACEH Protein, Fc,Avitag™

订购

ACE2 AC2-H5205 Human Mouse IgG Fc Tag HEK293 Human ACE2 / ACEH Protein, Mouse IgG1 Fc Tag (MALS verified)

订购

ACE2 AC2-M5248 Mouse His Tag HEK293 Mouse ACE2 / ACEH Protein, His Tag (MALS verified)

订购

ACE2 AC2-C52H7 Cynomolgus His Tag HEK293 Cynomolgus ACE2 / ACEH Protein, His Tag

订购

ACE2 AC2-R5246 Rat His Tag HEK293 Rat ACE2 / ACEH Protein, His Tag (MALS verified)

订购

ACE2 AC2-P5248 Paguma larvata His Tag HEK293 Paguma larvata ACE2 / ACEH Protein, His Tag (SPR verified)

订购

ACE2 AC2-M52H3 Mink His Tag HEK293 Mink ACE2 / ACEH Protein, His Tag (MALS verified)

订购

ASGR1 GS1-H82Q3 Human His Tag & Avi Tag HEK293 Biotinylated Human ASGR1 / ASGPR1, His,Avitag™

订购

ASGR1 AS1-H5243 Human His Tag HEK293 Human ASGR1 / ASGPR1 Protein, His Tag (SPR verified)

订购

ASGR1 AS1-H5253 Human Fc Tag HEK293 Human ASGR1 / ASGPR1 Protein, Fc Tag (MALS verified)

订购

验证数据
活性验证数据

Immobilized SARS-CoV-2 S1 protein, His Tag (Cat. No. S1N-C52H3) at 2 μg/mL (100 μL/well) can bind Biotinylated Human ACE2, His,Avitag (Cat. No. AC2-H82E6) with a linear range of 2-20 ng/mL (QC tested).

Protocol

Human ACE2, Fc Tag (Cat. No. AC2-H5257) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind recombinant SARS-CoV-2 Spike vaccine with an affinity constant of 16.9 nM as determined in a SPR assay (Biacore T200).

Protocol

输出疫苗抗原与ACE2结合的全面性研究——抗原与ACE2亲和力服务

可进行疫苗抗原与ACE2结合的快慢、强弱及机理等多方面的定量和定性的全面分析
提供多种优质抗原蛋白及不同验证方法(SPR、BLI等)
高标准的质量管理控制体系,数据质量满足申报要求
个性化方案及报告形式定制,最快次日即可出具报告
提供多地多平台检测服务
生物效价&免疫持久性检测
  • 抗体滴度检测
  • 中和抗体滴度检测
  • 基于流式细胞术的多突变联合检测
  • 新冠Spike蛋白萤光素酶假病毒
  • 广谱RBD蛋白中和抗体

满足疫苗开发各阶段(动物 & 人体)体内效价检测需求——S trimer/RBD/S1 IgG抗体滴度检测试剂盒(间接法ELISA)

可溯源至WHO国际标准血清 (G, NIBSC code 20/136),试剂盒标品与其相关性良好,检测数据具有实验室间可比性和标准性
提供适用于人、鼠、猴等不同种属血清抗体检测的试剂盒,满足临床前及临床实验需求
提供VOCs突变特异性IgG抗体滴度试剂盒,可用于疫苗针对突变的临床及临床前效价检测
试剂批间差小,试剂稳定
  • 临床前实验
  • 临床实验
货号 预包被抗原 产品描述 订购/预购
FCM-B02R Spike RBD Mouse SARS-CoV-2 Variants Total IgG 6-plex Panel (Flow Cytometry Multiplex Bead Assay)

预购

FCM-B03R Spike RBD Monkey SARS-CoV-2 Variants Total IgG 6-plex Panel (Flow Cytometry Multiplex Bead Assay)

预购

FCM-B07R Spike RBD Mouse SARS-CoV-2 Omicron Subvariants Total IgG 5-plex Panel (Flow Cytometry Multiplex Bead Assay)

预购

RAS-T112 Spike Trimer Mouse Anti-SARS-CoV-2 (BA.5) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T109 Spike Trimer Mouse Anti-SARS-CoV-2 (BA.4) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T121 Spike S1 Mouse Anti-SARS-CoV-2 (BA.4 & BA.5) Antibody IgG Titer Serologic Assay Kit (Spike S1)

订购

RAS-T108 Spike RBD Mouse Anti-SARS-CoV-2 (BA.4 & BA.5) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

订购

RAS-T114 Spike Trimer Mouse Anti-SARS-CoV-2 (BA.2.12.1) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T113 Spike RBD Mouse Anti-SARS-CoV-2 (BA.2.12.1) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

订购

RAS-T090 Spike S1 Mouse Anti-SARS-CoV-2 (BA.2) Antibody IgG Titer Serologic Assay Kit (Spike S1)

订购

RAS-T088 Spike RBD Mouse Anti-SARS-CoV-2 (BA.2) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

订购

RAS-T089 Spike protein Mouse Anti-SARS-CoV-2 (BA.2) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T061 Spike S1 Mouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike S1)

订购

RAS-T064 Spike S1 Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike S1)

预购

RAS-T059 Spike RBD Mouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

订购

RAS-T062 Spike RBD Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

预购

RAS-T060 Spike protein Mouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T063 Spike protein Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

预购

RAS-T086 Spike S1 Mouse Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike S1)

订购

RAS-T091 Spike RBD Mouse Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

订购

RAS-T070 Spike protein Mouse Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T084 Spike S1 Mouse Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike S1)

订购

RAS-T045 Spike S1 Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike S1)

订购

RAS-T047 Spike S1 Monkey Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike S1)

订购

RAS-T018 Spike RBD Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit

订购

RAS-T019 Spike RBD Monkey Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike RBD)

订购

RAS-T023 Spike protein Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T046 Spike protein Monkey Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

货号 预包被抗原 产品描述 订购/预购
FCM-B01R Spike RBD SARS-CoV-2 Variants Total IgG 6-plex Panel (Flow Cytometry Multiplex Bead Assay)

订购

FCM-B08R Spike RBD SARS-CoV-2 Variants Total IgG 6-plex Panel (Flow Cytometry Multiplex Bead Assay, Non-premixed)

订购

FCM-B09R Spike RBD Human SARS-CoV-2 Omicron Subvariants Total IgG 6-plex Panel (Flow Cytometry Multiplex Bead Assay)

预购

RAS-T134 Spike RBD Human Anti-SARS-CoV-2 (BA.5) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

预购

RAS-T057 Spike RBD Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

订购

RAS-T058 Spike protein Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T043 Spike Trimer Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T042 Spike RBD Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

订购

RAS-T032 Spike RBD Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

订购

RAS-T033 Spike protein Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T029 Spike RBD Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

订购

RAS-T030 Spike protein Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T026 Spike RBD Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

订购

RAS-T027 Spike protein Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T001 Spike S1 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike S1)

订购

RAS-T095 Spike S1 Anti-SARS-CoV-2 Antibody IgG Quantitative and Titer Detection Kit (Spike S1)

订购

RAS-T024 Spike RBD Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike RBD)

订购

RAS-T049 Spike RBD Anti-SARS-CoV-2 Antibody IgG Quantitative Detection Kit (Spike RBD)

订购

RAS-T093 Spike RBD Anti-SARS-CoV-2 Antibody IgG Quantitative and Titer Detection Kit (Spike RBD)

订购

RAS-T025 Spike protein Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T048 Spike protein Anti-SARS-CoV-2 Antibody IgG Quantitative Detection Kit (Spike Trimer)

订购

RAS-T094 Spike protein Anti-SARS-CoV-2 Antibody IgG Quantitative and Titer Detection Kit (Spike Trimer)

订购

RAS-T008 Nucleocapsid protein Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Nucleocapsid Protein)

订购

验证数据
检测示例数据

接种疫苗后的血清用新冠抗体滴度检测试剂盒(Cat.No.RAS-T024)进行验证,可准确测试血清中抗体滴度。经检测,试剂盒批间精密度<10%, 批内精密度:<15%。

Protocol

WHO血清标定结果

Protocol

经WHO国际标准血清(G,NIBSC code 20/136 )标定的试剂盒 (Cat.No. RAS-T048 )可用于新冠疫苗接种后血清样本中的IgG抗体的定量检测等,能够显著提高相关指标检测的效率和准确度,是对现有方式的重要补充。

Protocol

便捷高通量中和抗体检测替代方案——特异性中和抗体滴度试剂盒(竞争法ELISA)

可溯源至WHO国际标准血清 (G, NIBSC code 20/136),试剂盒标品与其相关性良好,
检测数据具有实验室间可比性和标准性
与假病毒检测结果相关性好,可作为假病毒中和活性检测的高通量替代方法
操作简单,实验仅需1.5-2h,可同时检测90+样本
提供突变(VOCs)特异性中和抗体检测试剂盒产品,可特异性识别不同突变
新冠突变 货号 产品描述 订购/预购
Wild type RAS-N022 Anti-SARS-CoV-2 Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

订购

Wild type RAS-N044 Anti-SARS-CoV-2 Neutralizing Antibody Quantitative Detection Kit (Spike RBD)

订购

Alpha | B.1.1.7 RAS-N028 Anti-SARS-CoV-2 (B.1.1.7) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

订购

Beta | B.1.351 RAS-N031 Anti-SARS-CoV-2 (B.1.351) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

订购

Gamma | P.1 RAS-N034 Anti-SARS-CoV-2 (P.1) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

订购

Delta | B.1.617.2 RAS-N040 Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

订购

Delta | B.1.617.2 RAS-N041 Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Titer Serologic Assay Kit (Spike Trimer)

订购

Omicron | B.1.1.529 RAS-N056 Anti-SARS-CoV-2 (B.1.1.529) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

订购

Omicron | BA.2 RAS-N087 Anti-SARS-CoV-2 (BA.2) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

订购

Omicron | BA.2.12.1 RAS-N120 Anti-SARS-CoV-2 (BA.2.12.1) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

订购

Omicron | BA.4 RAS-N107 Anti-SARS-CoV-2 (BA.4 & BA.5) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)

订购

Mutiplex FCM-N04R SARS-CoV-2 Variants Neutralizing Antibody 6-plex Panel (Flow Cytometry Multiplex Bead Assay)

预购

Mutiplex FCM-N06R SARS-CoV-2 Omicron Subvariants Neutralizing Antibody 5-plex Panel (Flow Cytometry Multiplex Bead Assay)

预购

验证数据
实验原理

竞争ELISA法

临床检测数据

接种疫苗后血清验证实验结果表明试剂盒(Cat. No. RAS-N022)对血清样本检测特异性好,准确度高。

假病毒验证

利用RAS-N022试剂盒与假病毒实验对16例康复病人的血清进行中和抗体检测。数据显示,两者具有很高的相关性(R2 =93.73)。

突变特异性结果

56例接种新冠灭活疫苗后血清,用野生型与突变中和抗体检测试剂盒进行检测,Alpha,Beta,Gamma,Delta检测结果均略有降低,其中Beta,Gamma降低较明显。

WHO血清标定结果

注:y = (A - D) / [1 + (x/C)^B] + D (A =1.55562 B =1.45522 C=14.42024 D=0.05532 r^2= 1)

少量样本一次性多变异株效价快速评价工具——基于流式细胞术的多因子联合检测试剂盒

创新基于流式细胞术全面覆盖野生型及五个VOC毒株(含Omicron),一次实验完成全球主流变异株检测;
提供不同Mouse、Monkey、Human不同种属产品,满足临床前到临床不同阶段实验需求;
同步性好,便于对各突变株结合抗体横向对比,减少不同实验产生的实验误差;
检测样本用量低,仅需5ul样本即可高通量完成多突变株结合/中和抗体检测;
检测时间短,2.5h内即可完成一次检测,支持一个工作日内重复实验;
经济高效,同等实验相比其他方法节约试剂成本6倍以上;
仪器适应性强,可与不同商家品牌流式细胞仪配套使用;
基于自主蛋白原料开发,产品性能和供货能力保障。
货号 产品描述
FCM-B01R SARS-CoV-2 Variants total IgG 6-plex Panel (Flow Cytometry Multiplex Bead Assay)
FCM-B02R Mouse SARS-CoV-2 Variants total IgG 6-plex Panel (Flow Cytometry Multiplex Bead Assay)
FCM-B03R Monkey SARS-CoV-2 Variants total IgG 6-plex Panel (Flow Cytometry Multiplex Bead Assay)
FCM-N04R SARS-CoV-2 Variants Neutralizing Antibody 6-plex Panel (Flow Cytometry Multiplex Bead Assay)
验证数据

A representative calibration curve generated by fitting the signals from the calibrators to a 4-parameter logistic model (4-PL). The MFI signal is proportional to the concentration of SARS-CoV-2 variant specific-IgG, in format of multiplex bead-based flow cytometry immunoassay.(Cat. No. FCM-B01R

A representative datapoint showing singlet bead population in P1 gate (left), SARS-CoV-2 variant immobilized beads classified by APC channel (middle, P2 ~ P7 gate), and measured fluorescence signal for each population in PE channel (right). Data was generated on BD FACSLyricTM Flow Cytometer, equipped with blue laser (488 nm) and red laser (640 nm) (Cat. No. FCM-B01R

抗体滴度检测金标准必须的关键试剂——新冠Spike蛋白萤光素酶假病毒

病毒原液感染细胞后萤光可达10^6 RLU
不具有复制能力,无致病性
权威性、高灵敏度的中和滴度检测方法
适用于抗体蛋白、血清等的中和效价检测,抑制率可达99%以上
货号 产品描述 订购/预购
PSSO-HLC016 SARS-CoV-2 Spike (Omicron BA.4 & BA.5) Fluc Pseudovirus

订购

PSSO-HLC015 SARS-CoV-2 Spike (Omicron BA.2.12.1) Fluc Pseudovirus

订购

PSSO-HLC017 SARS-CoV-2 Spike (Omicron BA.3) Fluc Pseudovirus

订购

PSSO-HLC014 SARS-CoV-2 Spike (Omicron BA.2) Fluc Pseudovirus

订购

PSSO-HLGB011 SARS-CoV-2 Spike (Omicron BA.2) Fluc-GFP Pseudovirus

订购

PSSO-HLC012 SARS-CoV-2 Spike (Omicron BA.1) Fluc Pseudovirus

订购

PSSO-HLGB003 SARS-CoV-2 Spike (Omicron) Fluc-GFP Pseudovirus

订购

PSSD-HLGB002 SARS-CoV-2 Spike (Delta) Fluc-GFP Pseudovirus

订购

PSSB-HLGB005 SARS-CoV-2 Spike (Beta) Fluc-GFP Pseudovirus

订购

PSSA-HLGB008 SARS-CoV-2 Spike (Alpha) Fluc-GFP Pseudovirus

订购

PSSM-HLGB007 SARS-CoV-2 Spike (Mu) Fluc-GFP Pseudovirus

订购

PSSL-HLGB006 SARS-CoV-2 Spike (Lambda) Fluc-GFP Pseudovirus

订购

PSSW-HLGB001 SARS-CoV-2 Spike (WT) Fluc-GFP Pseudovirus

订购

PSSW-HLGB010 SARS-CoV-2 Spike (D614G) Fluc-GFP Pseudovirus

订购

PSSD-HLGB004 SARS-CoV-2 Spike (Delta plus K417N) Fluc-GFP Pseudovirus

订购

PSSG-HLGB009 SARS-CoV-2 Spike (Gamma) Fluc-GFP Pseudovirus

订购

验证数据
产品适用于假病毒-抗体/血清中和实验

新冠(WT) Spike蛋白假病毒(Cat. No. PSSW-HLGB001)与新冠(Omicron) Spike蛋白假病毒(Cat. No. PSSO-HLGB003)均可被Spike RBD中和抗体(Cat. No. SPD-M265, S1N-M122)中和,抑制率达99%以上;已被报道Omicron突变株可逃逸的中和抗体REGN10987可以中和新冠Spike蛋白(WT)假病毒( Cat. No. PSSW-HLGB001 ),但无法有效中和新冠Spike蛋白(Omicron)假病毒( Cat. No. PSSO-HLGB003)。

新冠(Omicron) Spike蛋白假病毒(Cat. No. PSSO-HLGB003)可被Spike (Omicron) 蛋白免疫的小鼠血清中和,抑制率达99%以上。

血清成分对假病毒中和实验产生的影响可接受

新冠(WT) Spike蛋白假病毒(Cat. No. PSSW-HLGB001)、新冠(Delta) Spike蛋白假病毒(Cat. No. PSSD-HLGB002)、新冠(Omicron) Spike蛋白假病毒(Cat. No. PSSO-HLGB003)在不同基质(含0%, 2.5%或5%灭活人血清)中,均可被Spike RBD中和抗体(Cat. No. S1N-M122)中和。

Protocol

产品带有萤火虫萤光素酶、GFP双报告基因

新冠(WT) Spike蛋白假病毒(Cat. No. PSSW-HLGB001)与新冠(Omicron) Spike蛋白假病毒(Cat. No. PSSO-HLGB003)均具有较高的滴度。假病毒感染5×104人ACE2过表达细胞(Cat. No. CHEK-ATP042) 48 h后信号值可达106以上,适用于定量实验。

Protocol

新冠(WT) Spike蛋白假病毒(Cat. No. PSSW-HLGB001)、新冠(Delta) Spike蛋白假病毒(Cat. No. PSSD-HLGB002)、新冠(Omicron) Spike蛋白假病毒(Cat. No. PSSO-HLGB003) 含有绿色荧光蛋白报告基因,便于图像信息的获取。

Protocol

真正合格的中和抗体检测质控品——广谱RBD蛋白中和抗体

具备广谱中和活性,可有效中和多种主流突变株
经ELISA验证,特异性及结合活性良好
经假病毒实验验证,对所有VOCs突变株具有广谱中和活性
产品列表
货号 种属 产品描述 抗原表位 订购/预购
S1N-M122 Mouse Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) Spike RBD

订购

SPD-M265 Human Anti-SARS-CoV-2 Spike RBD Broadly Neutralizing Antibody, Human IgG1 (AM359b) (MALS verified) Spike RBD

订购

SAD-S35 Human Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG1 (AS35) Spike RBD

订购

SPD-M180 Human Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Human IgG1 (AM180) Spike RBD

订购

S1N-VM226 Mouse Biotinylated Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) (MALS verified) Spike RBD

订购

SCT-M369 Mouse Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Mouse IgG1 (AM122) Spike RBD

订购

SPD-M121 Mouse Anti-SARS-CoV-2 Spike NTD Antibody, Chimeric mAb, Human IgG1 (AM121) Spike NTD

订购

SPD-M128 Mouse Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM128) Spike RBD

订购

SPD-M162 Mouse Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgM (AM122) Spike RBD

订购

SPD-M58P1 Mouse Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgA1 (AM122) Spike RBD

订购

SPD-PM226 Mouse PE-Labeled Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) Spike RBD

订购

SPD-M201 Cynomolgus Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Cynomolgus IgG1 (AM122) Spike RBD

订购

验证数据
>ELISA验证数据

Anti-SARS-CoV-2 Spike RBD Neutralizing antibody (Cat.No.S1N-M122)neutralizes SARS-CoV-2 Spike RBD by inhibiting RBD: ACE2 interaction. The ACE2-coated plate is incubated with the wild type (WT) RBD or B.1.1.7, B.1.351, P.1, B.1.617.1, B.1.617.2 mutant and treated with the neutralizing antibody at increasing concentration. Percent inhibition is calculated based on the OD value.

Protocol

>ELISA验证数据

经假病毒实验体系验证,广谱型中和抗体(Cat.No.S1N-M122) 可以有效中和野生型及Alpha/Beta/Gamma/Delta突变株病毒,适合作为质控品,应用于针对突变株的中和抗体筛选、重组蛋白疫苗临床前及临床研究中的效价检测、血清中的中和抗体检测等。

Protocol

>>> 相关抗体产品活性经假病毒验证,点击查看详情。

>>> 点击查看更多SARS-CoV-2结合抗体、IgG抗体亚型及检测二抗

毒理研究
  • 抗体亚型检测试剂盒

快速获取ADE、VED研究关键结果——便捷高通量IgG抗体亚型检测试剂盒(间接法ELISA)

提供IgG1、IgG2、IgG3、IgG4不同亚型血清学检测用试剂盒
特异性好,可正确分型
产品稳定性及批间一致性良好
组分配套齐全,操作简单,可同时检测90+样本
新冠突变 货号 产品描述 订购/预购
Wild type RAS-T014 Anti-SARS-CoV-2 Antibody IgG1 Titer Serologic Assay kit

订购

Wild type RAS-T015 Anti-SARS-CoV-2 Antibody IgG2 Titer Serologic Assay kit

订购

Wild type RAS-T016 Anti-SARS-CoV-2 Antibody IgG3 Titer Serologic Assay kit

订购

Wild type RAS-T017 Anti-SARS-CoV-2 Antibody IgG4 Titer Serologic Assay kit

订购

Delta | B.1.617.2 RAS-T077 Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG1 Titer Serologic Assay Kit (Spike RBD)

订购

Delta | B.1.617.2 RAS-T078 Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG3 Titer Serologic Assay Kit (Spike RBD)

订购

Omicron | B.1.1.529 RAS-T065 Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG1 Titer Serologic Assay Kit (Spike RBD)

订购

Omicron | B.1.1.529 RAS-T066 Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG2 Titer Serologic Assay Kit (Spike RBD)

预购

Omicron | B.1.1.529 RAS-T067 Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG3 Titer Serologic Assay Kit (Spike RBD)

订购

Omicron | B.1.1.529 RAS-T068 Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG4 Titer Serologic Assay Kit (Spike RBD)

预购

验证数据

Cross-validation data for antibody subtype detection

>>> 如果您希望ACRO开发更多类型的SARS-CoV-2(COVID-19)的产品或有定制化的产品、服务需求,请点击提议

新冠疫苗生物效价评价整体解决方案
ACROBiosystems致力于为广大医药研发领域客户提供一个更简便快速的开发过程,在加速开发试剂产品的同时,也希望通过我司丰富的技术服务经验加速抗疫制品研发进程。ACROBiosystems现推出新冠疫苗生物效价评价整体解决方案,提供抗原定量检测服务(ELISA)、临床前/临床总抗体/中和抗体滴度检测服务(ELISA)、假病毒中和抗体检测服务以及抗体亚型检测服务,希望通过多快好省超值技术服务,助力新冠疫苗研发生产!

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ACRO蛋白产品助力新冠相关研究
ACROBiosystems致力于提供靶向治疗药物研发和诊断试剂盒开发过程中所需的靶点抗原、抗体及其他关键试剂和相关服务。针对新冠病毒开发的相关蛋白产品具有纯度高、批间差小的特点,产品经过严格的体外验证、细胞活性验证和假病毒验证,可应用于新冠病毒诊断、疫苗和治疗性抗体的各个阶段。已有多个课题组将ACROBiosystems蛋白产品应用于其新冠病毒相关的研究中,相关成果发表于Cell、Nature、Science等期刊。

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