Sortilin 靶点蛋白|抗体药物|临床药物信息

Sortilin信息

英文名称：Sortilin
中文名称：
靶点别称：100 kDa NT receptor，NT3，Glycoprotein 95，LDLCQ6，NTR3，Gp95，Sortilin 1，Neurotensin receptor 3

上市药物数量：0
临床药物数量：1
最高研发阶段：临床三期

Sortilin产品列表

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在线 (2)

物种

Human (2)

标签

属性

Protein (2)

标记

货号	物种	产品描述	蛋白结构	纯度	活性
SON-H52H5	Human	Human Sortilin / SORT1 Protein, His Tag (MALS verified)
SON-H82E9	Human	Biotinylated Human Sortilin / SORT1 Protein, His,Avitag™ (MALS verified)

Sortilin 分子别名

Sortilin,SORT1,100 kDa NT receptor,Glycoprotein 95,Gp95,Gp95LDLCQ6,Neurotensin receptor 3,NT3NTR3,Ntr3,sortilin 1,

Sortilin 分子背景

The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.

Sortilin 前沿进展

Sortilin临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Latozinemab	GSK-4527223; AL-001	临床三期	Alector, 葛兰素史克	阿尔茨海默病, 额颞痴呆, 肌萎缩性侧索硬化	详情

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Sortilin