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Sortilin信息

英文名称:Sortilin
中文名称
靶点别称:100 kDa NT receptor,NT3,Glycoprotein 95,LDLCQ6,NTR3,Gp95,Sortilin 1,Neurotensin receptor 3
上市药物数量:0
临床药物数量:1
最高研发阶段:临床三期

Sortilin 分子别名

Sortilin,SORT1,100 kDa NT receptor,Glycoprotein 95,Gp95,Gp95LDLCQ6,Neurotensin receptor 3,NT3NTR3,Ntr3,sortilin 1,

Sortilin 分子背景

The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.

Sortilin 前沿进展

Sortilin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Latozinemab GSK-4527223; AL-001 临床三期 Alector, 葛兰素史克 阿尔茨海默病, 额颞痴呆, 肌萎缩性侧索硬化 详情

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