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FOLR1信息

英文名称:Folate receptor alpha
中文名称:叶酸受体α
靶点别称:FRalpha,KB cells FBP,Adult folate-binding protein,Folate receptor 1,Folate receptor alpha,FR-alpha,FOLR1,Ovarian Tumor-Associated Antigen MOv18,Folate Receptor 1 (Adult),Folate Receptor, Adult,FOLR,FBP,Folate Binding Protein,FRα
上市药物数量:0
临床药物数量:11
最高研发阶段:批准上市

FOLR1产品列表

 
评论(2)
FO1-H5253|Human FOLR1 Protein, Fc Tag (MALS verified)
  1. 187XXXXXXX1
  2. 0人赞
  3. 经过实验验证该蛋白具有良好的活性,可用于后期小鼠等动物的免疫,对于筛选FOLR1抗体有很大帮助,建议增加猴属性的FC抗原
  4. >
  5. 2022-06-21
FO1-H52H1|Human FOLR1 Protein, His Tag (MALS verified)
  1. 187XXXXXXX1
  2. 0人赞
  3. 经过ELISA试验验证,该抗原具有良好的蛋白活性,可以用于下一步小鼠杂交瘤上清单克隆抗体的筛选和相关的功能验证
  4. >
  5. 2022-06-21
 

FOLR1 分子别名

FOLR-1,FBP,FOLR

FOLR1 分子背景

Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.

FOLR1 前沿进展

FOLR1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CBP-1008 CBP-1008 临床一期 同宜医药(苏州)有限公司 卵巢癌, 实体瘤, 乳腺癌, 鳞状细胞癌 详情
Vintafolide EC-145; MK-8109 临床二期 诺华制药 卵巢癌, 实体瘤, 肺腺癌, 乳腺癌, 子宫内膜癌, 非小细胞肺癌 详情
Noscapine-folate conjugate 临床一期 埃默里大学 血液肿瘤, 炎性疾病 详情
4S-CAR-FRa 4S-CAR-FRa 临床二期 深圳市免疫基因治疗研究院 移行细胞癌, 膀胱癌 详情
MOv19-BBz CAR-T cells Therapy 临床一期 宾夕法尼亚大学 卵巢癌, 腹膜癌, 输卵管癌 详情
MOv-18 IgE MOv-18 IgE 临床一期 伦敦国王学院, Cancer Research Uk 卵巢癌 详情
Farletuzumab MORAb-003 临床三期 Morphotek 卵巢癌, 实体瘤, 肺腺癌, 卵巢上皮癌, 腹膜癌, 输卵管癌 详情
MORAb-202 MORAb-202 临床二期 卫材株式会社, Morphotek, 百时美施贵宝 实体瘤 详情
STRO-002 SP-7219; SP-7675; SP-7676; STRO-002; DBCO-Alexa647-conjugated SP7219 临床一期 Sutro Biopharma 卵巢癌, 卵巢上皮癌, 腹膜癌, 输卵管癌, 子宫内膜癌, 子宫内膜样癌 详情
Arfolitixorin ISO-901; 6R-MTHF 临床三期 Isofol Medical Ab 直肠癌, 结肠癌, 骨肉瘤, 结直肠癌 详情
Mirvetuximab soravtansine IMGN-853; M9346-Asulfo-SPDB-DM4 临床三期 Immunogen Inc 卵巢癌, 实体瘤, 卵巢上皮癌, 乳腺癌, 腹膜癌, 输卵管癌, 子宫内膜癌 详情

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