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预偶联磁珠系列产品

背景
2020年5月18日,北京大学谢晓亮团队及其合作伙伴在顶级期刊《细胞》上发表研究论文, 报道了从康复病人血清中分离出具有高中和活性的抗体,可用于预防及治疗COVID-19。在这项研究中,该团队将偶联S RBD蛋白的磁珠应用于记忆B细胞的筛选,大幅提升了中和抗体的分离效率高达20倍,这也保证候选抗体库中有足量的能够结合RBD的抗体进行后续高中和活性筛选。小小的磁珠在这项重要研究成果中发挥了大大的作用,是这项研究的画龙点睛之笔。

图1 利用磁珠进行抗体筛选的过程

ACROBiosystems特色开发的预偶联磁珠是将独特的生物素化蛋白偶联到链霉亲和素磁珠上,可用于结合其他生物配体。磁珠的粒径、表面积大小及其均匀程度都将影响其性能,磁珠表面偶联的抗原蛋白质量更是衡量磁珠捕获效率的关键因素。ACRO 基于其独特的生物素标记蛋白产品,设计开发了一系列偶联有SARS-CoV-2 S1、SARS-CoV-2 RBD、CD3、BCMA等不同蛋白的具有超顺磁性的预偶联磁珠,这些磁珠具有粒径均匀、比表面积大、饱和浓度抗原包被等特点,可以表现出最佳性能,有效提高捕获效率,保证结果的重现性。
>>> 应用:免疫捕获、生物淘选、样品/细胞富集、分析实验样品预处理、流式细胞术。
产品列表
分子 货号 产品描述 订购/预购
ACE2 MBS-K013 Human ACE2-coupled Magnetic Beads

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Nucleocapsid protein MBS-K017 SARS-CoV-2 Nucleocapsid Protein-coupled Magnetic Beads

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Spike RBD MBS-K014 Human Anti-SARS-CoV-2 Spike RBD Antibody-coupled Magnetic Beads

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Spike RBD MBS-K032 SARS-CoV-2 Spike RBD (B.1.351) Coupled Magnetic Beads

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Spike RBD MBS-K033 SARS-CoV-2 Spike RBD (P.1) Coupled Magnetic Beads

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Spike RBD MBS-K034 SARS-CoV-2 Spike RBD (B.1.1.7) Coupled Magnetic Beads

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Spike RBD MBS-K037 SARS-CoV-2 (Delta) Spike RBD-coupled Magnetic Beads

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Spike RBD MBS-K043 SARS-CoV-2 (Omicron) Spike RBD-coupled Magnetic Beads

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Spike S1 MBS-K001 SARS-CoV-2 Spike S1-coupled Magnetic Beads

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Spike S1 MBS-K002 SARS-CoV-2 Spike RBD-coupled Magnetic Beads

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Spike protein MBS-K015 SARS-CoV-2 Spike Trimer-coupled Magnetic Beads

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Spike protein MBS-K016 SARS-CoV-2 Spike Trimer (D614G)-coupled Magnetic Beads

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Spike protein MBS-K029 SARS-CoV-2 Spike Trimer (B.1.1.7) Coupled Magnetic Beads

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Spike protein MBS-K030 SARS-CoV-2 Spike Trimer (B.1.351) Coupled Magnetic Beads

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Spike protein MBS-K031 SARS-CoV-2 Spike Trimer (P.1) Coupled Magnetic Beads

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Spike protein MBS-K038 SARS-CoV-2 (Delta) Spike Trimer-coupled Magnetic Beads

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Spike S2 MBS-K018 SARS-CoV-2 Spike S2-coupled Magnetic Beads

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Spike NTD MBS-K019 SARS-CoV-2 Spike NTD-coupled Magnetic Beads

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VEGF165 MBS-K036 Human VEGF165-coupled Magnetic Beads

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CTLA-4 MBS-K042 Human CTLA-4 coupled Magnetic Beads

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CD19 MBS-K005 Human CD19-coupled Magnetic Beads

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CD3 epsilon MBS-K026 Human CD3E-coupled Magnetic Beads

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CD3E & CD3D MBS-K003 Human CD3E & CD3D Heterodimer-coupled Magnetic Beads

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CD47 MBS-K023 Human CD47-coupled Magnetic Beads

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CD47 MBS-K059 PE-labeled Human CD47-coupled Magnetic Beads

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CD47 MBS-K080 APC-labeled Human CD47-coupled Magnetic Beads

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EGF R MBE-K012 Human EGFR-coupled Magnetic Beads

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Her2 MBS-K006 Human HER2-coupled Magnetic Beads

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Mesothelin MBS-K024 Human Mesothelin-coupled Magnetic Beads

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PCSK9 MBS-K054 Human PCSK9-coupled Magnetic Beads

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Protein L MPC-A008 Protein L-coupled Magnetic Beads (recommended for MPCLIA)

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HGF R MBS-K021 Human HGF R-coupled Magnetic Beads

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Angiopoietin-2 MBS-K035 Human ANGPT2-coupled Magnetic Beads

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B7-H3 MBS-K040 Human B7-H3(4Ig)-coupled Magnetic Beads

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BCMA MBS-K004 Human BCMA-coupled Magnetic Beads

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CD38 MBC-K010 Human CD38-coupled Magnetic Beads

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ROR1 MBR-K009 Human ROR1-coupled Magnetic Beads

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Siglec-2 MBS-K052 Human CD22-coupled Magnetic Beads

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Siglec-3 MBC-K008 Human CD33-coupled Magnetic Beads

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TROP-2 MBS-K028 Human TROP-2-coupled Magnetic Beads

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uPAR MBS-K076 Human uPAR-coupled Magnetic Beads

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Protein A MPC-A001 Protein A-coupled Magnetic Beads (recommended for MPCLIA)

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Protein G MPC-A002 Protein G-coupled Magnetic Beads (recommended for MPCLIA)

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CD73 MBS-K022 Human CD73-coupled Magnetic Beads

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Nectin-4 MBS-K039 Human Nectin-4-coupled Magnetic Beads

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PSMA MBP-K007 Human PSMA-coupled Magnetic Beads

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EGFRvIII MBS-K020 Human EGFRvIII-coupled Magnetic Beads

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FAP MBS-K077 Human FAP-coupled Magnetic Beads

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ASGR1 MBS-K055 Human ASGR1-coupled Magnetic Beads

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His MPC-A005 Anti-His Tag Antibody (Mouse IgG1)-coupled Magnetic Beads (recommended for MPCLIA)

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His MPC-A007 Anti-His Tag Antibody, Human IgG1-coupled Magnetic Beads (recommended for MPCLIA)

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AHG MPC-A004 Anti-Human IgG-coupled Magnetic Beads (recommended for MPCLIA)

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Streptavidin Beads MPC-A006 Streptavidin-Magnetic Beads (recommended for MPCLIA)

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Streptavidin Beads SMB-B01 Magnetic Beads™ Streptavidin

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Mouse IgG MPC-A003 Anti-Mouse IgG-coupled Magnetic Beads (recommended for MPCLIA)

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Anti-Human IgM MPC-A010 Anti-Human IgM-coupled Magnetic Beads (recommended for MPCLIA)

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Anti-FITC MPC-A009 Anti-FITC Antibody coupled Magnetic Beads (recommended for MPCLIA)

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>>> 相关产品推荐: Cat.No. SMB-B01 Magnetic beads™ Streptavidin(无偶联蛋白的链霉亲和素磁珠,可用作对照品) 此外,ACROBiosystems还可提供定制化服务,全方位满足药物研发领域的不同需求。 点击咨询

产品优势
低非特异性结合

ACROBiosystems对比多种磁珠,精选出粒径均匀,形状规整,具有超顺磁性的磁珠,得到了最低的非特异性结合。

图2 不同磁珠形态对比(A图为ACROBiosystems精选磁珠)

高捕获效率

链霉亲和素(SA)和生物素之间亲和力极强,生物素化蛋白预偶联不可逆。预偶联蛋白磁珠表面包被了饱和浓度的生物素标记抗原,结合能力强,可有效提升捕获效率。

静态吸附实验表明,RBD蛋白偶联磁珠可以很好地捕获anti-SARS-CoV-2 S1抗体,磁珠载量大于40μg/mg 磁珠。

图3 RBD偶联磁珠结合抗体量曲线

RBD偶联磁珠和ACE2蛋白的结合曲线表明,RBD蛋白偶联磁珠可以很好地结合ACE2蛋白。

图4 RBD偶联磁珠和ACE2蛋白的结合曲线

Protocol

BCMA偶联磁珠和BCMA抗体的结合曲线表明,BCMA蛋白偶联磁珠可以很好地结合抗BCMA抗体。

图5 BCMA偶联磁珠和抗BCMA抗体的结合曲线

稳定、便捷、高效

ACROBiosystems特别设计的预偶联蛋白磁珠为冻干状态,可长期稳定储存,多次冻融不影响结构和性能。重构后即可使用,无需活化,操作简便,可大大提高您的实验效率,节约时间和成本。

图6. ACRO磁珠在不同状态下的电镜图片 (Cat. No. SMB-B01),结果表明磁珠在3次冻融后结构稳定。

图7. 多次冻融后SARS-CoV-2 S RBD蛋白偶联磁珠(货号:MBS-K002)与S1抗体结合曲线与冻融前无显著性差异。

图8. 多次冻融后BCMA蛋白偶联磁珠(货号:MBS-K004)与BCMA抗体结合曲线与冻融前无显著性差异。

>>> 如果您有更多需求及建议,请 点此联系

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