TL1A 靶点蛋白|抗体药物|临床药物信息

TL1A信息

英文名称：Tumor necrosis factor superfamily member 15
中文名称：肿瘤坏死因子超家族成员15
靶点别称：VEGI192A，Vascular Endothelial Cell Growth Inhibitor，TNF Superfamily Ligand TL1A，TNFSF15，Tumor Necrosis Factor (Ligand) Superfamily， Member 15，Vascular Endothelial Growth Inhibitor-192A，VEGI，TL1A，Tumor Necrosis Factor Ligand 1B，TNLG1B，TNF Superfamily Member 15，Tumor Necrosis Factor Superfamily Member 15，TL1，TNF Ligand-Related Molecule 1，Tumor Necrosis Factor Ligand Superfamily Member 15，MGC129934，MGC129935

上市药物数量：0
临床药物数量：2
最高研发阶段：临床二期

TL1A产品列表

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产品库

在线 (5)

物种

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属性

Protein (5)

标记

货号	物种	产品描述
TLA-H5243	Human	Human TL1A / TNFSF15 Protein, His Tag (MALS verified)
TLA-C5241	Cynomolgus/Rhesus macaque	Cynomolgus/Rhesus macaque TL1A / TNFSF15 Protein, His Tag
TLA-H52Q1	Human	Biotinylated Human TL1A / TNFSF15 Protein, His,Avitag™
TLA-H5244	Human	Human TL1A / TNFSF15 Protein, His Tag
TLA-M5243	Mouse	Mouse TL1A Protein, His Tag (MALS verified)

TL1A 分子别名

TL1A, VEGI-251, TNFSF15

TL1A 分子背景

TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.

TL1A 前沿进展

TL1A临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
PRA-023	PRA-023	临床二期	Prometheus Biosciences Inc	炎症性肠疾病, 间质性肺疾病, 溃疡性结肠炎, 弥漫性硬皮病, 克罗恩病	详情
PF-06480605	PF-06480605	临床二期	辉瑞制药有限公司	炎症性肠疾病, 溃疡性结肠炎, 克罗恩病	详情

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TL1A