Claudin-9 靶点蛋白|抗体药物|临床药物信息

Claudin-9信息

英文名称：Claudin-9
中文名称：Claudin-9
靶点别称：DFNB-116，Claudin 9，DFNB116

上市药物数量：0
临床药物数量：0
最高研发阶段：临床前

Claudin-9产品列表

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在线 (2)

物种

Human (2)

标签

His Tag & Strep Tag (1)

属性

Protein (2)

标记

Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
CL9-H5586	Human	Human Claudin-9 / CLDN9 Protein, His,Twin-Strep Tag (Detergent) (SPR verified)
CL9-H52P5	Human	Human Claudin-9 / CLDN9 Full Length Protein (VLP)

Claudin-9 分子别名

CLDN9

Claudin-9 分子背景

Claudin-9 belongs to the claudin family. Claudins constitute integral membrane proteins responsible for solute and electrolyte permeability of the tight junction that serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Tight junctions also play a critical role in maintaining cell polarity and signal transductions. Claudin-9 creates charge specific channels in the paracellular space, plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity, is required to preserve sensory cells in the hearing organ because claudin-9-defective tight junctions fail to shield the basolateral side of hair cells from the K+-rich endolymph. Its ion barrier function is essential in the cochlea, but appears to be dispensable in other organs. Is one of the entry cofactors for hepatitis C virus; it enables HCV entry into target cells just as efficiently as CLDN1.

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Claudin-9

Claudin-9信息

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Claudin-9 分子别名

Claudin-9 分子背景

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