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TREM2信息

英文名称:Triggering receptor expressed on myeloid cells 2
中文名称:触发在骨髓细胞上2表达的受体
靶点别称:TREM-2,Triggering receptor expressed on monocytes 2,PLOSL2,Trem2b,Trem2a,Trem2c,Triggering Receptor Expressed On Myeloid Cells 2a
上市药物数量:0
临床药物数量:1
最高研发阶段:临床申请

TREM2产品列表

 
评论(4)
TR2-M52H3|Mouse TREM2 Protein, His Tag
  1. 176XXXXXXX6
  2. 4人赞
  3. Mouse TREM2 ECD-his试剂,起初计划用于免疫实验中的ELISA Binding实验,每个浓度点均有binding,结合曲线完整,EC50合适,优化下包被浓度再进一步实验;
  4. 2021-10-12
TR2-H5254|Human TREM2 Protein, Fc Tag
  1. 139XXXXXXX1
  2. 1人赞
  3. 我们公司用于检测的蛋白通常都是Arco家的,通常会用于Elisa结合活性和亲和力的检测,效果很好。支持一下。
  4. >
  5. 2022-07-08
TR2-H82E7|Biotinylated Human TREM2 Protein, His,Avitag™
  1. 159XXXXXXX6
  2. 1人赞
  3. TREM2胞外区存在2个糖基化位点 糖基化复杂程度高 如果选择将TREM2直接偶联生物素 生物素随机结合K极大可能遮盖暴露的抗原表位氨基酸 选择Acro定向标记生物生物素化抗原 可避免上午表位遮蔽问题 适用于链霉亲和素偶联磁珠筛选噬菌体抗体哭
  4. >
  5. 2022-08-23
 

TREM2 分子别名

Triggering receptor expressed on myeloid cells 2,TREM2,TREM-2

TREM2 分子背景

Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor of the immunoglobulin superfamily. The TREM2 is found in various tissue macrophages, such as CNS microglia, bone osteoclasts, alveolar, peritoneal and intestinal macrophages. TREM2 is also present on cultured bone marrow-derived macrophages and monocyte-derived dendritic cells. Some research have identified a rare variant of TREM2 that is a risk factor for Alzheimer disease (AD), which is the most common form of late-onset dementia.The extracellular region of TREM2 contains a single immunoglobulin superfamily domain and binds polyanionic ligands, such as bacterial lipopolysaccharide (LPS) and phospholipids8. Upon ligand binding, TREM2 transmits intracellular signals through an adaptor, DAP12 (also known as TYRO protein tyrosine kinase-binding protein (TYROBP)), which is associated with the transmembrane region of TREM2 and which recruits the protein tyrosine kinase SYK through its cytosolic immunoreceptor tyrosine-based activation motifs (ITAMs). TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.

TREM2 前沿进展

TREM2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
PY-314 PY-314; PY314 Gilead Sciences Inc 详情
AL-002 AL-002a; AL-002-a; AL-002 艾伯维, Alector 详情

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