Fc gamma RIIB / CD32b 靶点蛋白|抗体药物|临床药物信息

Fc gamma RIIB / CD32b信息

英文名称：Low affinity immunoglobulin gamma Fc region receptor II-b
中文名称：低亲和力免疫球蛋白γFc区受体II-B
靶点别称：IgG Fc Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor (CD32)，Fc Gamma Receptor IIb，IgG Fc Receptor II-B，Fc-Gamma RII-B，FcRII-B，CDw32，FCG2，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B，Fc Fragment Of IgG， Low Affinity II， Receptor For (CD32)，Fc Gamma RIIb，CD32 Antigen，CD32B，FCGR2，Fc-gamma-RIIb，FCGR2B，IGFR2，CD32，Fc Fragment Of IgG Receptor IIb，Fc-Gamma RII-C，Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C，Fc Fragment Of IgG， Low Affinity IIb， Receptor For (CD32)

上市药物数量：0
临床药物数量：4
最高研发阶段：临床三期

Fc gamma RIIB / CD32b产品列表

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在线 (9)

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货号	物种	产品描述
CDB-M52H7	Mouse	Mouse Fc gamma RIIB / CD32b Protein, His Tag (SPR & BLI & MALS verified)
CDB-C5224	Cynomolgus	Cynomolgus Fc gamma RIIB / CD32b Protein, His Tag (MALS & SPR verified)
CDB-C82E4	Cynomolgus	Biotinylated Cynomolgus Fc gamma RIIB / CD32b Protein, His,Avitag™ (SPR & BLI & MALS verified)
CDB-M82E8	Mouse	Biotinylated Mouse Fc gamma RIIB / CD32b Protein, Avitag™,His Tag (SPR & BLI & MALS verified)
CDB-R52H3	Rat	Rat Fc gamma RIIB / CD32b Protein, His Tag (MALS verified)
SCCHO-ATP060H	Human	CHO/Human CD32b Stable Cell Line (High Expression) Development Service
SCCHO-ATP060L	Human	CHO/Human CD32b Stable Cell Line (Low Expression) Development Service
SCCHO-ATP060M	Human	CHO/Human CD32b Stable Cell Line (Medium Expression) Development Service
SCJUR-STF071	Human	Human CD32b (Luc) Jurkat Reporter Cell Development Service

Fc gamma RIIB / CD32b 分子别名

FCGR2B,CD32b,CD32,FCG2,IGFR2,CDw32

Fc gamma RIIB / CD32b 分子背景

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.

Fc gamma RIIB / CD32b 前沿进展

Fc gamma RIIB / CD32b临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
PRV-3279	MGD-010; PRV-3279; CD32BxCD79B	临床二期	Macrogenics Inc	药物相关的副作用和不良反应	详情
BI-1607	BI-1607	临床二期	Bioinvent International Ab	实体瘤, 食道癌, 胃癌, 乳腺癌, 转移性乳腺癌, 腺癌	详情
Obexelimab	XmAb-5871; AMG-729	临床三期	Xencor Inc	免疫球蛋白G4相关疾病, 系统性红斑狼疮	详情
BI-1206	6G-11; BI-1206	临床二期	Bioinvent International Ab	B-细胞淋巴瘤, 实体瘤, 华氏巨球蛋白血症, 非霍奇金淋巴瘤, 慢性淋巴细胞白血病	详情

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Fc gamma RIIB / CD32b