Integrin alpha V beta 6 靶点蛋白|抗体药物|临床药物信息

Integrin alpha V beta 6信息

英文名称：Integrin alpha-V/beta-6
中文名称：整合素α-V/β-6复合体
靶点别称：

上市药物数量：0
临床药物数量：4
最高研发阶段：临床二期

Integrin alpha V beta 6产品列表

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在线 (6)

物种

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属性

Protein (6)

标记

货号	物种	产品描述
IT6-H52E1	Human	Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free
IT6-H82E4	Human	Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
IT6-M52W9	Mouse	Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified)
IT6-C52W9	Cynomolgus	Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free
IT6-M82W9	Mouse	Biotinylated Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
IT6-R52E6	Rat	Rat Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified)

IT6-H82E4|Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)

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2人赞

Great communication from the Acro team--quickly received an email detailing the estimated delivery timeframe and asking if that timeframe was acceptable. Product was ready per the timeline provided by the Acro biosystems team and shipped. This was a new product for us (though we’ve used other acro biosystems products previously) and worked well for our intended use with Surface Plasmon Resonance (SPR). Thank you all!
2022-04-02

Integrin alpha V beta 6 分子别名

Integrin alpha V beta 6,ITGAV&ITGB6

Integrin alpha V beta 6 分子背景

Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

Integrin alpha V beta 6 前沿进展

Integrin alpha V beta 6临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
OTT-166	OTT-166	临床二期	OcuTerra Therapeutics Inc	糖尿病视网膜病变	详情
[18F]FP-R01-MG	[18F]FP-R01-MG; [18F]FP-R01-MG-F2	临床一期	Pliant Therapeutics Inc, 斯坦福大学, 中国医学科学院北京协和医学院	特发性肺纤维化, 新型冠状病毒肺炎, 胰腺癌, 原发性硬化性胆管炎, 脑转移, 肺癌, 非小细胞肺癌	详情
IDL-2965	IDL-2965	临床二期	Indalo Therapeutics Inc	非酒精性脂肪肝, 特发性肺纤维化	详情
PLN-74809	PLN-74809	临床二期	Pliant Therapeutics Inc	特发性肺纤维化, 新型冠状病毒肺炎, 成人呼吸窘迫综合征, 原发性硬化性胆管炎	详情

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Integrin alpha V beta 6