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RAGE信息

英文名称:Advanced glycosylation end product-specific receptor
中文名称:晚期糖基化终产物特异性受体
靶点别称:Receptor for advanced glycosylation end products,AGER,Advanced Glycosylation End-Product Specific Receptor,RAGE,Receptor For Advanced Glycation End-Products Variant 20,Receptor For Advanced Glycation End-Products,RAGE Isoform NtRAGE-Delta,RAGE Isoform SRA
上市药物数量:0
临床药物数量:3
最高研发阶段:临床三期

RAGE产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
 
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RAGE 分子别名

AGER,RAGE

RAGE 分子背景

Advanced glycosylation end product-specific receptor (AGER) is also known as RAGE, and is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. AGER is highly expressed in endothelial cells. AGER mediates interactions of advanced glycosylation end products (AGE), and also accumulates in vascular tissue in aging and at an accelerated rate in diabetes, as well as acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGER / RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.

RAGE 参考文献

RAGE临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
TRC-4186 TX-41XX; TRC-4186 临床二期 Torrent Pharmaceuticals 心脏衰竭, 糖尿病并发症
TRC-041266 TRC-041266 临床三期 Torrent Pharmaceuticals 心脏衰竭 详情

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