登录 | 注册    关注公众号  
微信公众号
搜索
 > 【RAGE】

RAGE信息

英文名称:Advanced glycosylation end product-specific receptor
中文名称:晚期糖基化终产物特异性受体
靶点别称
上市药物数量:0
临床药物数量:3
最高研发阶段:临床三期

RAGE产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
 
评论(0)
 

RAGE 分子别名

AGER,RAGE

RAGE 分子背景

Advanced glycosylation end product-specific receptor (AGER) is also known as RAGE, and is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. AGER is highly expressed in endothelial cells. AGER mediates interactions of advanced glycosylation end products (AGE), and also accumulates in vascular tissue in aging and at an accelerated rate in diabetes, as well as acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGER / RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.

RAGE 前沿进展

RAGE临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

消息提示

请输入您的联系方式,再点击提交!

确定