Fc gamma RIIIA / CD16a 靶点蛋白|抗体药物|临床药物信息

Fc gamma RIIIA / CD16a信息

英文名称：Low affinity immunoglobulin gamma Fc region receptor III-A
中文名称：低亲和力免疫球蛋白γFc段受体III-A
靶点别称：Fc Fragment Of IgG， Low Affinity IIIa， Receptor (CD16a)，CD16a Antigen，IGFR3，FCG3，Fc Fragment Of IgG， Low Affinity IIIa， Receptor For (CD16)，Fc Fragment Of IgG， Low Affinity III， Receptor For (CD16)，Immunoglobulin G Fc Receptor III，Fc-Gamma Receptor III-2 (CD 16)，Neutrophil-Specific Antigen NA，Fc-Gamma Receptor IIIb (CD16)，Fc Gamma Receptor III-A，Fc Gamma Receptor IIIa，Fc-Gamma RIIIa，Fc-Gamma RIII，FCGRIII，FcRIIIa，FCR-10，FCRIII，IMD20，CD16，Low affinity immunoglobulin gamma Fc region receptor III-A，

上市药物数量：0
临床药物数量：9
最高研发阶段：临床二期

Fc gamma RIIIA / CD16a产品列表

筛选结果

产品库

在线 (12)

物种

Human (12)

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属性

标记

货号	物种	产品描述
CD8-H52H4	Human	Human Fc gamma RIIIA / CD16a (V176) Protein, His Tag (SPR & BLI & MALS verified)
CDA-H5220	Human	Human Fc gamma RIIIA / CD16a (F176) Protein, His Tag (SPR & BLI & MALS verified)
CDA-H5290	Human	Human Fc gamma RIIIA / CD16a (V176) Protein, SUMO,His Tag (MALS & BLI verified)
CDA-H52H6	Human	Human Fc gamma RIIIA / CD16a (F176, S197P) Protein, His Tag (MALS&SPR verified)
CDA-H52S1	Human	Human Fc gamma RIIIA / CD16a (V176) Protein, HSA,His Tag (MALS & BLI verified)
CDA-H82E8	Human	Biotinylated Human Fc gamma RIIIA / CD16a (F176) Protein, Avitag™,His Tag (SPR & BLI & MALS verified)
CDA-H82E9	Human	Biotinylated Human Fc gamma RIIIA / CD16a (V176) Protein, Avitag™,His Tag (HPLC & SPR & BLI verified)
SCCHO-ATP059H	Human	CHO/Human CD16a (158V) Stable Cell Line (High Expression) Development Service
SCCHO-ATP059L	Human	CHO/Human CD16a (158V) Stable Cell Line (Low Expression) Development Service
SCCHO-ATP059M	Human	CHO/Human CD16a (158V) Stable Cell Line (Medium Expression) Development Service
SCJUR-STF067	Human	Human CD16a (158V) (Luc) Jurkat Reporter Cell Development Service
SCJUR-STF068	Human	Human CD16a (158F) (Luc) Jurkat Reporter Cell Development Service

CDA-H5220|Human Fc gamma RIIIA / CD16a (F176) Protein, His Tag (SPR & BLI & MALS verified)

158XXXXXXX6

6人赞

我们购买了测定Fc受体相关的几个受体蛋白，主要用于FC受体fortebio亲和力的测定，考察抗体与FC受体结合强弱，与同类产品的其他品牌蛋白相比，纯度和活性都比较好，而且物流快，发货及时。希望以后有其他产品的采购！
2019-10-16

CDA-H5220|Human Fc gamma RIIIA / CD16a (F176) Protein, His Tag (SPR & BLI & MALS verified)

136XXXXXXX0

3人赞

我们做SPR需要用的这个蛋白，做FC通用的检测项目需要用到这CD16 V 模式的强binding，按照Acro的大概实验流程，很容易就检测出来分子结合，这个蛋白好使！！！
2020-12-01

CDA-H82E8|Biotinylated Human Fc gamma RIIIA / CD16a (F176) Protein, Avitag™,His Tag (SPR & BLI & MALS verified)

178XXXXXXX2

2人赞

这个是表征分析的必须要蛋白CD16A（F176）这个蛋白与CD16A（V176）是人种的不同表征分析的时候两个都需要做抗体或者ADC的表征分析（受体与抗体）亲和力大小活性好才是真的好，我已经第三次购买这个蛋白活性特别好
2022-04-22

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Fc gamma RIIIA / CD16a 分子别名

FCGR3A,CD16A,FCG3,FCGR3,IGFR3

Fc gamma RIIIA / CD16a 分子背景

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibodydependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.

Fc gamma RIIIA / CD16a 前沿进展

Fc gamma RIIIA / CD16a临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
FT-538	FT-538	临床二期	Fate Therapeutics Inc	实体瘤, 髓样白血病, 新型冠状病毒肺炎, 成人呼吸窘迫综合征, 急性单核细胞白血病, 急性髓细胞样白血病	详情
GMA-161	GMA-161	临床一期	赛诺菲, Macrogenics Inc	特发性血小板减少性紫癜	详情
AFM-13	AFM-13	临床二期	德州大学安德森癌症中心	周围T-细胞淋巴瘤, 霍奇金病, 蕈样真菌病	详情
FT-516	FT-516	临床一期	University Of Minnesota, Fate Therapeutics Inc	B-细胞淋巴瘤, 卵巢癌, 实体瘤, 腹部肿瘤, 新型冠状病毒肺炎, 急性髓细胞样白血病, 输卵管癌	详情
AFM-28	AFM-28	临床一期	Affimed	急性早幼粒细胞白血病, 肿瘤	详情
AFM-24	AFM-24	临床二期	Affimed	实体瘤	详情
SM-3321	SM-3321	临床一期	北京烁星生物医药科技有限公司	急性髓细胞样白血病	详情
FT-576	FT-576	临床一期	University Of Minnesota, Fate Therapeutics Inc	骨髓瘤, 多发性骨髓瘤	详情
FT-596	FT-596	临床一期	Fate Therapeutics Inc	B-细胞淋巴瘤, 弥漫性大B-细胞淋巴瘤, 非霍奇金淋巴瘤, 急性髓细胞样白血病, 慢性淋巴细胞白血病	详情

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Fc gamma RIIIA / CD16a