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Fc gamma RIIIA / CD16a信息

英文名称:Low affinity immunoglobulin gamma Fc region receptor III-A
中文名称:低亲和力免疫球蛋白γFc段受体III-A
靶点别称:Low affinity immunoglobulin gamma Fc region receptor III-A,FCGR3,CD16A,Fc-gamma RIII-alpha,FCGR3A,Fc Fragment Of IgG Receptor IIIa,Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a),CD16a Antigen,IGFR3,FCG3,Fc Fragment Of IgG, Low Affinity IIIa, Rece
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

Fc gamma RIIIA / CD16a产品列表

 
评论(1)
CDA-H5220|Human Fc gamma RIIIA / CD16a (F176) Protein, His Tag (SPR & BLI verified)
  1. 158XXXXXXX6
  2. 5人赞
  3. 我们购买了测定Fc受体相关的几个受体蛋白,主要用于FC受体fortebio亲和力的测定,考察抗体与FC受体结合强弱,与同类产品的其他品牌蛋白相比,纯度和活性都比较好,而且物流快,发货及时。希望以后有其他产品的采购!
  4. 2019-10-16
 

Fc gamma RIIIA / CD16a Molecule Synonym Name

FCGR3A,CD16A,FCG3,FCGR3,IGFR3

Fc gamma RIIIA / CD16a 分子背景

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody­dependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.

Fc gamma RIIIA / CD16a 参考文献

Fc gamma RIIIA / CD16a临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AFM-24 AFM-24 临床二期 Affimed 肿瘤 详情
AFM-13 AFM-13 临床二期 University Of Texas M. D. Anderson Cancer Center 周围T-细胞淋巴瘤, 霍奇金病, 蕈样真菌病 详情
OXS-3550 OXS-3550-TriKE; OXS-3550; OXIS-3550; 161533-TriKE; 161533 TriKE; GTB-3550 临床二期 University Of Minnesota, Oxis Biotech 系统性肥大细胞增多症, 骨髓增生异常综合征, 肥大细胞白血病, 急性髓细胞样白血病 详情

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