登录 | 注册    关注公众号  
微信公众号
搜索

Nectin-4信息

英文名称:Nectin-4
中文名称:细胞黏附分子nectin-4
靶点别称:PRR4,LNIR,Nectin cell adhesion molecule 4,PVRL4,Ig superfamily receptor LNIR,Poliovirus receptor-related protein 4,NECTIN4,Poliovirus Receptor-Related 4,Nectin-4,Nectin 4,EDSS1
上市药物数量:1
临床药物数量:3
最高研发阶段:批准上市

Nectin-4产品列表

 
评论(10)
NE4-H52H3|Human Nectin-4 Protein, His Tag
  1. 156XXXXXXX8
  2. 11人赞
  3. 采购本抗原进行单克隆抗体制备,以及抗体筛选等工作,本抗原经过SDS-PHAGE检测之后,条带单一,无杂蛋白,用于抗体筛选,筛选出的抗体与该抗原具体很好的亲和力
  4. >
  5. 2019-10-11
NE4-M52H3|Mouse Nectin-4 Protein, His Tag
  1. 156XXXXXXX8
  2. 4人赞
  3. 采购该产品,主要用于抗体分子的种属交叉反应实验,使用该蛋白包被ELISA板子,通过ELISA的方法检测抗体同鼠源Nectin-4的亲和力,在前期的验证阶段,使用已经获批的Enfortumab Vedotin的抗体进行验证,其亲和力EC50值为27ng/ml.
  4. 2021-08-19
NE4-H52H3|Human Nectin-4 Protein, His Tag
  1. 136XXXXXXX4
  2. 3人赞
  3. 用于SPR检测,目前看单次实验结果所测定供试阳性对照亲和力约发表物数据的0.5倍,测定结果还是挺可靠的(SJDK-2203-019实验报告)。
  4. 2022-03-31
 

Nectin-4 分子别名

NECTIN4,LNIR, PRR4, PVRL4

Nectin-4 分子背景

Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.

Nectin-4 前沿进展

Nectin-4上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Enfortumab vedotin ASG-22CE; AGS-22ME; AGS-22C3; AGS-M6; AGS-22C3E; ASG-22M6E; DLE8519RWM; ASG-22ME; AGS-22M6E 批准上市 Agensys, Seattle Genetics Padcev EU 移行细胞癌 Astellas Pharma Inc, Astellas Pharma Europe Bv 2019-12-18 实体瘤, 肾肿瘤, 转移性上皮癌, 移行细胞癌, 肿瘤, 膀胱癌, 原位癌, 前列腺癌, 尿道癌, 泌尿系肿瘤, 输尿管肿瘤 详情

Nectin-4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
BT-8009 BT-8009 Bicycle Tx Ltd 详情
BT-7480 BT-7480 临床二期 Bicycle Therapeutics 实体瘤, 肿瘤 详情
Nectin4/FAP-targeted CAR-T cell therapy (The Sixth Affiliated Hospital of Wenzhou Medical University) 临床一期 温州医科大学 实体瘤 详情
9MW2821 9MW2821; 9MW-2821; 9-MW2821; 9-MW-2821 临床二期 迈威(上海)生物科技股份有限公司 实体瘤 详情

消息提示

请输入您的联系方式,再点击提交!

确定