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Nectin-4信息

英文名称:Nectin-4
中文名称:细胞黏附分子nectin-4
靶点别称:LNIR,Nectin cell adhesion molecule 4,PVRL4,Ig superfamily receptor LNIR,Poliovirus receptor-related protein 4,NECTIN4,Poliovirus Receptor-Related 4,Nectin-4,Nectin 4,PRR4,EDSS1
上市药物数量:1
临床药物数量:1
最高研发阶段:批准上市

Nectin-4产品列表

 
评论(8)
NE4-M52H3|Mouse Nectin-4 Protein, His Tag
  1. 156XXXXXXX8
  2. 0人赞
  3. 采购该产品,主要用于抗体分子的种属交叉反应实验,使用该蛋白包被ELISA板子,通过ELISA的方法检测抗体同鼠源Nectin-4的亲和力,在前期的验证阶段,使用已经获批的Enfortumab Vedotin的抗体进行验证,其亲和力EC50值为27ng/ml.
  4. 2021-08-19
NE4-M52Ha|Mouse Nectin-4 Protein, His Tag, low endotoxin
  1. 159XXXXXXX3
  2. 0人赞
  3. 在多种肿瘤细胞中过表达,在肿瘤细胞增殖,分化,迁移,侵袭等过程中发挥重要作用,在我们实验中给予了很大的帮助,对项目的顺利开展起到了很好的帮助
  4. 2021-08-18
NE4-C52H4|Cynomolgus Nectin-4 Protein, His Tag
  1. 188XXXXXXX5
  2. 2人赞
  3. 采购该蛋白Cynomolgus Nectin-4 Protein, His Tag的应用用途为杂交瘤抗体先导分子,与猴的种属交叉检测检测。与阳参抗体的ELISA亲和结果显示该蛋白具有良好的亲和活性,
  4. 2021-07-17
 

Nectin-4 分子别名

NECTIN4,LNIR, PRR4, PVRL4

Nectin-4 分子背景

Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.

Nectin-4 前沿进展

Nectin-4上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Enfortumab vedotin AGS-M6; AGS-22ME; ASG-22CE; ASG-22ME; AGS-22M6E; ASG-22M6E; AGS-22C3; DLE8519RWM 批准上市 Agensys, Seattle Genetics Padcev United States 尿路上皮癌 Astellas Pharma Us Inc 2019-12-18 实体瘤, 肾肿瘤, 转移性上皮癌, 移行细胞癌, 肿瘤, 膀胱癌, 尿道癌, 原位癌, 泌尿系肿瘤, 输尿管肿瘤 详情

Nectin-4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Nectin4/FAP-targeted CAR-T cell therapy (The Sixth Affiliated Hospital of Wenzhou Medical University) 临床一期 温州医科大学 肿瘤 详情

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