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 > 【B7-H3】重组蛋白信息

B7-H3信息

英文名称:CD276 antigen
中文名称:CD276抗原
靶点别称:B7H3,CD276,CD276 Molecule,Costimulatory Molecule,4Ig-B7-H3,B7RP-2,PSEC0249,UNQ309/PRO352,B7-H3,CD276 antigen,B7 homolog 3
上市药物数量:0
临床药物数量:8
最高研发阶段:临床三期

B7-H3产品列表

 
评论(1)
B73-H52E2|Human B7-H3 / CD276 Protein, His Tag (MALS verified)
  1. 138XXXXXXX2
  2. 5人赞
  3. 用过很多种类Acro的重组蛋白,包括一些热门的靶点抗原,像LAG3、B7H3等,还有一些重组的细胞因子像IL-36α/β/γ等。说一下体验吧,外包装盒很酷炫的感觉喔~靶点抗原作为ELISA包被原料还是很好用的,跟抗体结合活性高,特异性也很强,唯一“不足”的地方可能就是价格有点子小贵吧。细胞因子类的用作过细胞功能学方面的检测,虽然刺激效果也不错,但是有些跟R&D的刺激效果比起来还是有一定改善空间,希望Acro能不断提升产品性能,越做越好!
  4. 2020-01-17
 

B7-H3 Molecule Synonym Name

B7-H3,CD276,B7 homolog 3

B7-H3 分子背景

B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.

B7-H3 参考文献

B7-H3临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
MGC-018 MGC-018 临床二期 Macrogenics 肿瘤 详情
SCRI-CARB7H3 SCRI-CARB7H3 临床一期 Seattle Children'S Hospital 中枢神经系统肿瘤, 胶质瘤 详情
Monoclonal antibody 8H9 I-124 124I-8H9; 124I-8H9-(B7-H3) 临床二期 Memorial Sloan Kettering Cancer Center 胶质瘤 详情
DS-7300 DS-7300 临床二期 第一三共株式会社 肿瘤 详情
4SCAR-276 4SCAR-276 临床二期 深圳市免疫基因治疗研究院 肿瘤 详情
Monoclonal antibody 8H9 I-131 8H9-MAb; 131-I-8H9; 131I-8H9-(B7-H3) 临床三期 Memorial Sloan Kettering Cancer Center 神经母细胞瘤, 腹膜癌, 转移癌 详情
B7-H3 CAR-T cell therapy (Zhejiang University) 临床二期 浙江大学新加坡校友会 胶质母细胞瘤 详情
Enoblituzumab MGA-271 临床二期 Macrogenics 横纹肌肉瘤, 头颈癌, 促结缔组织增生性小圆细胞肿瘤, 肾细胞癌, 头颈部鳞状细胞癌, 三阴性乳腺肿瘤, 肾母细胞瘤, 膀胱癌, 前列腺癌, 神经母细胞瘤, 骨肉瘤, 尤因肉瘤, 黑色素瘤, 非小细胞肺癌 详情

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