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FAP信息

英文名称:Fibroblast activation protein alpha
中文名称:成纤维细胞激活蛋白α
靶点别称:EC:3.4.21.-,EC:3.4.21.26,EC:,3.4.21.-,EC:3.4.14.5,170 kDa melanoma membrane-bound gelatinase,Seprase,Dipeptidyl peptidase FAP,APCE,Integral membrane serine protease,FAP,Post-Proline Cleaving Enzyme,Gelatine degradation protease FAP,Fibroblast activation protein alpha,Surface-expressed protease,FAPalpha,SIMP,Fibroblast Activation Protein, Alpha,Serine Integral Membrane Protease,Prolyl Endopeptidase FAP,EC 3.4.21.26,EC 3.4.14.5,EC 3.4.21.-,DPPIV,FAPA,EC:,3.4.14.5
上市药物数量:0
临床药物数量:7
最高研发阶段:临床二期

FAP 分子别名

FAP,FAPalpha,SIMP,Seprase,APCE

FAP 分子背景

FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

FAP 前沿进展

FAP临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
OMTX-705 OMTX-705 临床一期 Oncomatryx Biopharma Sl 实体瘤 详情
FAP-DR5 RG-7386; RO-6874813 Millennium Pharmaceuticals Inc, 罗氏 详情
177Lu-FAP-2286 177Lu-FAP-2286 3b Pharmaceuticals 实体瘤 详情
68Ga-FAP-2286 68Ga-FAP-2286; 68-Ga-FAP-2286 临床二期 3b Pharmaceuticals 实体瘤, 转移癌 详情
MP-0310 MP-0310; AMG-506 临床一期 Molecular Partners Ag, 安进 实体瘤 详情
Simlukafusp alfa FAP-IL2v; RG-7461; aFAP-IL2v; RO-6874281; FAP-IL2v FP 罗氏 详情
Talabostat (BioXcel) PT-100; BXCL-701 临床二期 Inveni 前列腺癌 详情
Talabostat PT-100 Midatech Pharma Plc 详情
RO-7300490 RO-7300490; RG-6189 临床一期 罗氏 实体瘤, 肿瘤 详情
Nectin4/FAP-targeted CAR-T cell therapy (The Sixth Affiliated Hospital of Wenzhou Medical University) 临床一期 温州医科大学 实体瘤 详情

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