FAP 靶点蛋白|抗体药物|临床药物信息

FAP信息

英文名称：Fibroblast activation protein alpha
中文名称：成纤维细胞激活蛋白α
靶点别称：EC:3.4.21.-，EC:3.4.21.26，EC:，3.4.21.-，EC:3.4.14.5，170 kDa melanoma membrane-bound gelatinase，Seprase，Dipeptidyl peptidase FAP，APCE，Integral membrane serine protease，FAP，Post-Proline Cleaving Enzyme，Gelatine degradation protease FAP，Fibroblast activation protein alpha，Surface-expressed protease，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，EC:，3.4.14.5

上市药物数量：0
临床药物数量：12
最高研发阶段：临床二期

FAP产品列表

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产品库

在线 (11)

物种

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属性

Protein (11)

标记

货号	物种	产品描述
FAP-C52H3	Cynomolgus	Cynomolgus FAP Protein, His Tag, active dimer (MALS verified)
FAP-C82Q5	Cynomolgus	Biotinylated Cynomolgus FAP Protein, His,Avitag™, active dimer (MALS verified)
FAP-H5244	Human	Human FAP Protein, His Tag, active dimer (MALS verified)
FAP-H5263	Human	Human FAP Protein, Fc Tag, active dimer (MALS verified)
FAP-H82Q6	Human	Biotinylated Human FAP Protein, His,Avitag™, active dimer (MALS verified)
FAP-HF243	Human	FITC-Labeled Human FAP Protein, His Tag
FAP-HF263	Human	FITC-Labeled Human FAP Protein, Fc Tag
FAP-HP245	Human	PE-Labeled Human FAP Protein, His Tag (Site-specific conjugation)
FAP-M52H3	Mouse	Mouse FAP Protein, His Tag, active dimer (MALS verified)
FAP-M82Q8	Mouse	Biotinylated Mouse FAP Protein, His,Avitag™, active dimer (MALS verified)
FAP-R5246	Rat	Rat FAP Protein, His Tag, active dimer (MALS verified)

FAP-H5244|Human FAP Protein, His Tag, active dimer (MALS verified)

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0人赞

利用FAP的酶活性考察所设计的前药的敏感性，将FAP与前药共孵育，观察到样品溶液从无色变为蓝色，表明前药响应于FAP释放出了原形药物，也说明了本产品的酶活性很好，没有问题。
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2023-04-16

FAP-H82Q6|Biotinylated Human FAP Protein, His,Avitag™, active dimer (MALS verified)

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0人赞

购买此产品主要用于羊驼的纳米抗体免疫，内毒素含量低于同类产品，且质量稳定，一直是我们购买抗体的首选品牌，且价格合理，以后后继续采购
2023-03-29

FAP分子别名

FAP,FAPalpha,SIMP,Seprase,APCE

FAP分子背景

FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

FAP临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Simlukafusp alfa	FAP-IL2v; RG-7461; aFAP-IL2v; RO-6874281; FAP-IL2v FP	临床二期	罗氏	头颈癌, 实体瘤, 食道癌, 肾细胞癌, 乳腺癌, 宫颈癌, 黑色素瘤	详情
177Lu-PNT6555(Point Biopharma)	PNT-6555	临床一期	Point Biopharma Inc	实体瘤, 食道癌, 肉瘤, 结直肠癌, 胰腺导管癌, 黑色素瘤	详情
Talabostat	PT-100; BXCL-701	临床二期	Midatech Pharma Plc, Bioxcel Therapeutics Inc	神经母细胞瘤, 黑色素瘤, 慢性淋巴细胞白血病, 腺癌, 生殖细胞和胚胎肿瘤, 非小细胞肺癌, 转移癌, 胰腺导管癌, 肺癌, 小细胞癌, 脑癌, 实体瘤, 肉瘤, 前列腺癌, 中枢神经系统肿瘤, 神经内分泌瘤, 皮肤肿瘤, 胰腺癌, 肾肿瘤, 卵巢癌, 肝癌	详情
68Ga-FAPI-RGD	68Ga-FAPI-RGD	临床一期	北京协和医院	肺癌	详情
177Lu-FAP-2286	177Lu-FAP-2286	临床二期	3B Pharmaceuticals GmbH	实体瘤	详情
MP-0317	MP-0317	临床一期	Molecular Partners Ag	实体瘤, 肿瘤	详情
Nectin4/FAP-targeted CAR-T cell therapy (The Sixth Affiliated Hospital of Wenzhou Medical University)		临床一期	温州医科大学, 温州医科大学附属第六医院	实体瘤	详情
OMTX-705	OMTX-705	临床一期	Oncomatryx Biopharma Sl	实体瘤	详情
[18F]FAPI-74	FAPI-74; [18F]FAPI-74	临床二期	Sofie	胆管癌, 胃癌, 胰腺癌, 胆管上皮癌, 结直肠癌, 胰腺导管癌, 胃肠道癌症, 肝细胞癌	详情
RO-7300490	RO-7300490; RG-6189	临床一期	罗氏	实体瘤, 肿瘤	详情
68Ga-FAP-2286	68Ga-FAP-2286; 68-Ga-FAP-2286	临床二期	3B Pharmaceuticals GmbH	实体瘤, 转移癌	详情
MP-0310	MP-0310; AMG-506	临床一期	Molecular Partners Ag, 安进	实体瘤	详情

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FAP

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