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STEAP1信息

英文名称:Six-transmembrane epithelial antigen of the prostate 1
中文名称:前列腺六跨膜上皮抗原1
靶点别称:PRSS24,Six-transmembrane epithelial antigen of prostate 1,STEAP,STEAP1,STEAP Family Member 1,Six Transmembrane Epithelial Antigen Of The Prostate 1,STEAP1 Metalloreductase,Six Transmembrane Epithelial Antigen Of The Prostate,Metalloreductase STEAP1,EC 1.16.1.-,EC:1.16.1.-
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

STEAP1分子别名

STEAP1, PRSS24, STEAP

STEAP1分子背景

Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is an integral membrane protein that is highly up-regulated on the cell surface of several human cancers, making it a promising therapeutic target to manage these diseases. It shares sequence homology with three enzymes (STEAP2-STEAP4) that catalyze the NADPH-dependent reduction of iron(III). Taking into account its high specificity and overexpression in human cancers, STEAP1 is nowadays a promising candidate to be imposed as a therapeutic target.

STEAP1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
89Zr-DFO-MSTP2109A 临床二期 Memorial Sloan Kettering Cancer Center, 基因泰克 前列腺癌 详情
STEAP1 CART Cell Therapy(PromiCell) 临床二期 PromiCell Therapeutics Inc, 弗莱德哈钦森癌症研究中心 去势抵抗性前列腺肿瘤, 前列腺癌 详情
Xaluritamig AMG-509 临床一期 Xencor Inc, 安进 去势抵抗性前列腺肿瘤 详情
ABBV-969 ABBV-969; ABBV969 临床一期 艾伯维, Immunogen Inc 去势抵抗性前列腺肿瘤 详情

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