Claudin-6 靶点蛋白|抗体药物|临床药物信息

Claudin-6信息

英文名称：Claudin 6
中文名称：紧密连接蛋白6
靶点别称：UNQ757/PRO1488，Claudin-6，CLDN6，Claudin 6，Skullin

上市药物数量：0
临床药物数量：5
最高研发阶段：临床二期

Claudin-6产品列表

筛选结果

产品库

在线 (2)

物种

Human (2)

标签

His Tag & Strep Tag (1)

属性

Protein (2)

标记

Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
CL6-HF2G5	Human	Human Claudin-6 / CLDN6 Full Length Protein (VLP)
CL6-H5289	Human	Human Claudin-6 / CLDN6 Protein, His,Twin-Strep Tag (Detergent)

CL6-HF2G5|Human Claudin-6 / CLDN6 Full Length Protein (VLP)

176XXXXXXX3

4人赞

目前国内做Claudin 6靶点的公司还不是太多，销售这个蛋白的公司不多，并且因为Claudin6是四次跨膜蛋白，生产相也对困难一些，去年做活性方法时市场上还没有合适的蛋白，今年也有好几家公司用VLP或者NMP技术生产出了全长Claudin6，但通过比较还是Acro的性价比最高，不仅便宜而且很好用，普通Elisa的话0.05ug/well就能得到很好的结合曲线，有需可购买。
2022-07-14

CL6-HF2G5|Human Claudin-6 / CLDN6 Full Length Protein (VLP)

158XXXXXXX8

0人赞

购买VLP平台制备的CLDN6蛋白用于抗体筛选的Elisa检测实验，该蛋白性能稳定，可以取得理想结果，会持续购买。
2022-09-22

Claudin-6 分子别名

Claudin-6/CLDN6

Claudin-6 分子背景

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-6, also knows as CLDN6, is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. And it is one of the entry cofactors for hepatitis C virus. The methylation of CLDN6 may be involved in esophageal tumorigenesis. The gene of CLDN6 is adjacent to another family member CLDN9 on chromosome 16.

Claudin-6 前沿进展

Claudin-6临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
DS-9606a	DS-9606a; DS-9606-a	临床一期	Daiichi Sankyo Inc	卵巢癌, 肿瘤, 转移癌, 生殖细胞和胚胎肿瘤	详情
AMG-794	AMG-794	临床一期	安进	卵巢上皮癌, 非小细胞肺癌	详情
CLDN6 CAR-T cell therapy (BioNTech)	BNT-211	临床二期	Biontech Se	实体瘤	详情
CLDN6-CAR-NK Cell Therapy		临床二期	广州医科大学附属第二医院	卵巢癌, 睾丸肿瘤, 子宫内膜癌	详情
BNT-142	BNT-142	临床二期	Biontech Se	实体瘤	详情

会议日历

会议一览

Claudin-6