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ENPP3信息

英文名称:Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
中文名称:核苷酸内焦磷酸酶/磷酸二酯酶家族成员-3
靶点别称:EC:3.1.4.1,E-NPP 3,PD-Ibeta,NPPase,CD203c,PDNP3,Phosphodiesterase I/nucleotide pyrophosphatase 3,Nucleotide diphosphatase,ENPP3,DJ914N13.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3),Phosphodiesterase-I Beta,Phosphodiesterase I Beta,CD203c Antigen,Gp130RB13-6,NPP3,B10,Ectonucleotide pyrophosphatase/phosphodiesterase family member 3,Ectonucleotide Pyrophosphatase/Phosphodiesterase 3,DJ1005H11.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3),EC:3.6.1.9
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

ENPP3 分子别名

ENPP3,CD203c,NPP3,E-NPP3,PD-Ibeta,NPPase,PDNP3

ENPP3 分子背景

The human NPP family contains seven members which can be classified into two groups according to their substrate preferences. The first class comprises the nucleotide-degrading proteins NPP1, 3 and 4. NPP3 (CD203c, ENPP3) is expressed in multiple organs, including on epithelial and mucosal surfaces, and notably on basophils and mast cells. Activation of basophils by antigen-bound IgE leads to release of inflammatory mediators and rapid upregulation of NPP3 to the cell surface. This protein is in fact a common marker for diagnosing allergen sensitivity with patient basophils by flow cytometry. Basophils and mast cells mediate the response to certain pathogens, as well as acute and chronic allergic reactions. Following activation, these cells release ATP, which further stimulates them in an autocrine manner. NPP3 upregulation serves to degrade ATP and suppress chronic allergic inflammation (but not the acute response).

ENPP3 前沿进展

ENPP3临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
XmAb-819 XmAb-819 临床一期 Xencor Inc 肾肿瘤, 肾细胞癌 详情

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