Recombinant Proteins iso9001 ISO13485
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TSLP信息

英文名称:Thymic stromal lymphopoietin
中文名称:胸腺基质淋巴细胞生成素
靶点别称:Thymic stromal lymphopoietin,TSLP
上市药物数量:0
临床药物数量:1
最高研发阶段:临床三期

TSLP Molecule Synonym Name

TSLP

TSLP 分子背景

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

TSLP 参考文献

TSLP临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Tezepelumab AMG-157; MEDI-9929 临床三期 安进 阻塞性肺疾病, 鼻息肉, 肺疾病, 哮喘, 呼吸道超敏反应, 鼻窦炎, 支气管疾病, 速发型超敏反应, 慢性阻塞性肺疾病, 特应性皮炎, 超敏反应 详情

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