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CD155信息

英文名称:CD155 Antigen
中文名称:CD155抗原
靶点别称:Poliovirus receptor,PVS,NECL-5,PVR,Nectin-Like Protein 5,CD155 Antigen,Nectin-Like 5,CD155,NECL5,TAGE4,HVED,PVR Cell Adhesion Molecule
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

CD155产品列表

 
评论(5)
CD5-H5251|Human CD155 / PVR Protein, Fc Tag
  1. 185XXXXXXX0
  2. 2人赞
  3. 该产品用于药物发现高通量筛选,ACRO的TIGIT与CD155具有很好的亲和力,我们用该蛋白对建立了ELISA和FRET体系,并且筛选到了一些苗头化合物。蛋白保存近一年,活性一致稳定。
  4. 2021-09-05
CD5-H5223|Human CD155 / PVR Protein, His Tag (MALS verified)
  1. 156XXXXXXX1
  2. 2人赞
  3. 用作疫苗研发的分析检测验证等实验。ACROBiosystems生物素标记蛋白的生产采用我们独家的HEKMax®表达平台进行。作为表达源,人体HEK293细胞比其他类型的细胞有着诸多优势。
  4. 2021-12-15
CD5-H5251|Human CD155 / PVR Protein, Fc Tag
  1. 158XXXXXXX1
  2. 2人赞
  3. 该蛋白主要用于分子筛选,用于ELISA实验,该货号的CD155蛋白与TIGIT有很强的结合能力,能很方便的应用于方法开发。
  4. 2019-09-26
 

CD155 分子别名

PVR,FLJ25946,PVS,CD155,TAGE4,HVED,NECL5

CD155 分子背景

CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.

CD155 前沿进展

CD155临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Lerapolturev 临床二期 美国国立癌症研究所, Istari Oncology, 杜克大学医学中心 室管膜瘤, 髓母细胞瘤, 实体瘤, 胶质母细胞瘤, 少突神经胶质瘤, 膀胱癌, 脑癌, 乳腺癌, 星形细胞瘤, 神经胶质肉瘤, 胚胎癌, 胶质瘤, 黑色素瘤 详情

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