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 > 【EGF】重组蛋白信息

EGF信息

英文名称:Epidermal growth factor
中文名称:表皮生长因子
靶点别称:Epidermal Growth Factor,Pro-Epidermal Growth Factor,Epidermal Growth Factor (Beta-Urogastrone),Urogastrone,Beta-Urogastrone,URG,EGF,HOMG4
上市药物数量:1
临床药物数量:2
最高研发阶段:批准上市

EGF产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
EGF-H525b
Human
Human EGF Protein, Mouse IgG2a Fc Tag
EGF-M5265
Mouse
Mouse EGF Protein, Fc Tag
EGF-H52H3
Human
Human EGF Protein, His Tag
 
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EGF 分子别名

Barnham KJ,et al. 1998, Protein Science 7 (8): 1738–49.

EGF 分子背景

Human epidermal growth factor (EGF) is also known as HOMG4 and  URG,and is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR. Epidermal growth factor can be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. All family members contain one or more repeats of the conserved amino acid sequence. The biological effects of salivary EGF include healing of oral and gastroesophageal ulcers, inhibition of gastric acid secretion, stimulation of DNA synthesis as well as mucosal protection from intraluminal injurious factors such as gastric acid, bile acids, pepsin, and trypsin and to physical, chemical and bacterial agents. Because of the increased risk of cancer by EGF, inhibiting it decreases cancer risk.

EGF 参考文献

EGF上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
PX-070101 PX-070101 批准上市 Praxis Pharmaceuticals Colombia 糖尿病足溃疡 Praxis Pharmaceuticals 2015-07-01 糖尿病足溃疡 详情

EGF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
KP673 KP-673 临床一期 赛生医药(中国)有限公司 非小细胞肺癌 详情
Recombinant anti-EGFR chimeric monoclonal antibody (Shanghai CP Guojian) CPGJ-602; 602; CPGJ602; CPGJ 602 临床二期 三生国健药业(上海)股份有限公司 结直肠癌 详情

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