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CD79B信息

英文名称:B-cell antigen receptor complex-associated protein beta chain
中文名称:B细胞抗原受体复合物相关蛋白β链
靶点别称:B29,Immunoglobulin-associated B29 protein,Ig-beta,B-cell-specific glycoprotein B29,CD79B,CD79b Molecule,CD79b Molecule, Immunoglobulin-Associated Beta,IGB,CD79B Antigen (Immunoglobulin-Associated Beta),CD79b Antigen,AGM6,B-Cell Antigen Receptor Complex-As
上市药物数量:1
临床药物数量:2
最高研发阶段:批准上市

CD79B Molecule Synonym Name

CD79b,B29,IGB,Ig-beta

CD79B 分子背景

B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

CD79B 参考文献

CD79B上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Polatuzumab vedotin RO-5541077-000; RG-7596; FCU-2711; DCDS-4501A; RO-5541077 批准上市 Seattle Genetics, 基因泰克 Polivy Japan 弥漫性大B-细胞淋巴瘤 F. Hoffmann-La Roche Ag 2019-06-10 B-细胞淋巴瘤, 弥漫性大B-细胞淋巴瘤, 滤泡中心淋巴瘤, 非霍奇金淋巴瘤 详情

CD79B临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Iladatuzumab vedotin DCDS-0780A; RO-7032005 临床一期 罗氏 非霍奇金淋巴瘤 详情
PRV-3279 MGD-010; PRV-3279; CD32BxCD-79B 临床二期 Macrogenics 自身免疫疾病, 系统性红斑狼疮 详情

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