Glypican 3 靶点蛋白|抗体药物|临床药物信息

Glypican 3信息

英文名称：Glypican-3
中文名称：磷脂酰肌醇聚糖3
靶点别称：OCI-5，SGBS1，DGSX，SGBS，SDYS，SGB，MXR7，OCI5，GPC3，Glypican-3，Glypican 3，Glypican Proteoglycan 3，GTR2-2，Secreted Glypican-3，Intestinal protein OCI-5，Heparan Sulphate Proteoglycan

上市药物数量：0
临床药物数量：10
最高研发阶段：临床二期

Glypican 3产品列表

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在线 (12)

物种

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属性

Protein (12)

标记

货号	物种	产品描述
GP3-H5223	Human	Human Glypican 3 / GPC3 (S359F) Protein, His Tag, low endotoxin
GP3-H5258	Human	Human Glypican 3 / GPC3 Protein, Fc Tag, low endotoxin
GP3-M5254	Mouse	Mouse Glypican 3 / GPC3 Protein, Fc Tag
GP3-C5256	Cynomolgus	Cynomolgus Glypican 3 / GPC3 Protein, Fc Tag
GP3-C5225	Cynomolgus	Cynomolgus Glypican 3 / GPC3 Protein, His Tag
GP3-M52H3	Mouse	Mouse Glypican 3 / GPC3 Protein, His Tag
GP3-H82E5	Human	Biotinylated Human Glypican 3 / GPC3 Protein, His,Avitag™ (MALS verified)
GP3-HF258	Human	FITC-Labeled Human Glypican 3 / GPC3 Protein, Fc Tag
GP3-H52H4	Human	Human Glypican 3 / GPC3 Protein, His Tag (MALS verified)
GP3-HF2H1	Human	FITC-Labeled Human Glypican 3 / GPC3 Protein, His Tag
GP3-H5257	Human	Human Glypican 3 / GPC3 Protein, Llama IgG2b Fc Tag, low endotoxin
GP3-C5259	Cynomolgus	Cynomolgus Glypican 3 / GPC3 Protein, Llama IgG2b Fc Tag, low endotoxin

GP3-HF258|FITC-Labeled Human Glypican 3 / GPC3 Protein, Fc Tag

180XXXXXXX6

3人赞

GPC3目前也是实体瘤的一个热门靶点，购买这款产品，是用于CART细胞阳性率的检测，与我们自己纯化表达的蛋白（加hFc tag,需要用荧光标记的二抗），结果一致，不过这个不用染二抗，还是方便很多
2019-10-11

Glypican 3 Molecule Synonym Name

GPC3,OCI5,Glypican-3,GTR2-2,MXR7,DGSX,SDYS ,SGB,SGBS,SGBS1

Glypican 3 分子背景

Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3 / GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.

Glypican 3 参考文献

Glypican 3临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Anti-GPC3 chimeric antigen receptor T cell therapy (Hunan Yongren Medical Innovation/Guangdong Zhaotai InVivo Biomedicine)		临床一期	湖南昭泰医疗集团	肝癌, 肺癌	详情
GPC-3298306	GPC-3298306	临床二期	National Cancer Center Of Japan	卵巢癌, 肝细胞癌
Anti-GPC3 CAR T-cell therapy (Nanjing University)		临床一期	南京大学	肝细胞癌	详情
GPC3-T2 CAR-T cell therapy (The Second Affiliated Hospital of Guangzhou Medical University)		临床一期	广州医科大学附属第二医院	鳞状细胞癌, 肝细胞癌
GLYCAR T cell therapy (Baylor College of Medicine)	GLYCAR	临床一期	贝勒医学院	肝细胞癌	详情
MDX-1414	MDX-1414	临床一期	百时美施贵宝	肿瘤
Anti-GPC3 chimeric antigen receptor T cell therapy (Shanghai Genechem)		临床二期	上海吉凯基因医学科技股份有限公司	肝癌, 肝细胞癌	详情
ERY-974	ERY-974	临床一期	中外制药株式会社	实体瘤	详情
Codrituzumab	GC-33; RG-7686; RO-5137382	临床二期	中外制药株式会社, 罗氏	肝细胞癌	详情
GPC3-CAR-T cell therapy	CSG-GPC-3; KJgpc3-001; CAR-GPC3 T-cell; anti-GPC-3 CAR T; GPC3-CAR/CSG-GPC3	临床一期	科济生物医药（上海）有限公司	实体瘤, 鳞状细胞癌, 肝细胞癌	详情

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Glypican 3 重组蛋白