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B7-H4信息

英文名称:V-set domain-containing T-cell activation inhibitor 1
中文名称:含V区域T细胞激活抑制因子1
靶点别称:V-Set Domain-Containing T-Cell Activation Inhibitor 1,Immune costimulatory protein B7-H4,B7h.5,B7 homolog 4,T-cell costimulatory molecule B7x,V-Set Domain Containing T Cell Activation Inhibitor 1,B7X,B7 Family Member, H4,T Cell Costimulatory Molecule B7x,B7S1,B7 Superfamily Member 1,VCTN1,PRO1291,FLJ22418,B7H4,B7-H4,Protein B7S1
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

B7-H4产品列表

 
评论(7)
B74-H82E2|Biotinylated Human B7-H4 Protein, Avitag™,His Tag (recommended for biopanning)
  1. 150XXXXXXX1
  2. 3人赞
  3. 总共购买了600ug的这款biotin的抗原,用于液相panning和亲和力成熟的screening。这个抗原稳定性很好,质量过关,每次试验的可重复性高。 用这个抗原筛到了高亲和力的针对这靶点的抗体。并且用这个抗原做亲和力成熟的筛选,也获得了亲和力提高10倍的抗体。推荐购买哦~~
  4. 2019-10-11
B74-H8222|Biotinylated Human B7-H4 Protein, His Tag, ultra sensitivity (primary amine labeling)
  1. 150XXXXXXX0
  2. 2人赞
  3. 买本产品是对该免疫检查点靶点感兴趣,用于噬菌体展示筛选抗体。 蛋白稳定,活性高,包被效果好,已经筛到心仪的序列了。
  4. 2021-11-01
B74-H5222|Human B7-H4 Protein, His Tag
  1. 151XXXXXXX5
  2. 1人赞
  3. 一个新的试验不得不需要尝试新的抗体试剂,知道了这个品牌后,就毫不犹豫的下单了,疫情期间发货速度也快,一点没有耽误试验,经过多次的验证证明了这个试剂的稳定与可靠性,目前已经成为我们实验室的首选试剂!!!
  4. 2022-04-21
 

B7-H4 分子别名

B7-H4,VTCN1,B7S1,B7h.5

B7-H4 分子背景

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

B7-H4 前沿进展

B7-H4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AZD-8205 AZD-8205 临床二期 阿斯利康 卵巢癌, 胆管上皮癌, 乳腺癌, 子宫内膜癌 详情
NC-762 NC-762 详情
HS-20089 HS-20089 临床一期 上海翰森生物医药科技有限公司 实体瘤 详情
PF-07260437(Pfizer) PF-07260437 辉瑞 详情
SGN-B7H4V SGN-B-7H-4V; SGNB-7H4V; SGNB-7H-4V; SGN-B7H4V Seagen Inc 详情
XMT-1660 XMT-1660 临床一期 Mersana Therapeutics Inc 卵巢癌, 腹部肿瘤, 三阴性乳腺肿瘤, 肿瘤, 乳腺癌, 输卵管癌, 子宫内膜癌 详情
Alsevalimab FPA-150 临床一期 Five Prime Therapeutics Inc 实体瘤, 卵巢癌, 肿瘤, 乳腺癌, 子宫内膜癌 详情
HBM-7008 HBM7008; HBM-7008; R-7008 临床一期 和铂医药 实体瘤 详情
GEN-1047 GEN-1047 临床二期 Genmab A/S 卵巢癌, 乳腺癌, 子宫肿瘤 详情

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