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OX40 Ligand信息
英文名称：Tumor necrosis factor ligand superfamily member 4
中文名称：OX40配体
靶点别称：CD134L，OX-40L，TNLG2B，OX4OL，GP34，CD252 Antigen，CD134 Ligand，TAX transcriptionally-activated glycoprotein 1，Tax-Transcriptionally Activated Glycoprotein 1， 34kD，CD252，OX40 ligand，OX40L，TNFSF4，Tumor necrosis factor ligand superfamily member 4，Glycoprotein Gp34，TNF Superfamily Member 4，TXGP1，Tax-Transcriptionally Activated Glycoprotein 1 (34kD)，Tumor Necrosis Factor (Ligand) Superfamily， Member 4，Tumor Necrosis Factor (Ligand) Superfamily Member 4，Tumor Necrosis Factor Superfamily Member 4，Tumor Nec
中文名称：OX40配体
靶点别称：CD134L，OX-40L，TNLG2B，OX4OL，GP34，CD252 Antigen，CD134 Ligand，TAX transcriptionally-activated glycoprotein 1，Tax-Transcriptionally Activated Glycoprotein 1， 34kD，CD252，OX40 ligand，OX40L，TNFSF4，Tumor necrosis factor ligand superfamily member 4，Glycoprotein Gp34，TNF Superfamily Member 4，TXGP1，Tax-Transcriptionally Activated Glycoprotein 1 (34kD)，Tumor Necrosis Factor (Ligand) Superfamily， Member 4，Tumor Necrosis Factor (Ligand) Superfamily Member 4，Tumor Necrosis Factor Superfamily Member 4，Tumor Nec
上市药物数量：0
临床药物数量：5
最高研发阶段：临床二期
临床药物数量：5
最高研发阶段：临床二期
OX40 Ligand产品列表
产品库
属性
评论(5)
OXL-H52Q8|Human OX40 Ligand / TNFSF4 Protein, His Tag (active trimer) (MALS verified)
- 153XXXXXXX5
- 使用该产品Human_OX40_Ligand主要出于抗体筛选的目的，应用于ELISA阻断实验，该蛋白和ACRO的Human OX40-His(OX0-H5224)是有很好的结合的，我们也筛选获得了一系列的阻断型抗体和非阻断型抗体，ACRO可靠的材料有益于差异化药物先导分子的顺利开发。
- 2022-05-21
0人赞
OXL-H5266|Human OX40 Ligand / TNFSF4 Protein, Fc Tag (active trimer) (MALS verified)
- 135XXXXXXX9
- 我们做抗体筛选试验，本试剂质量很好，顺丰物流也快，通过抗原筛选我们筛选到高亲和的抗体，表达抗体的细胞也得到很好富集
- 2022-03-31
0人赞
OXL-H52Q8|Human OX40 Ligand / TNFSF4 Protein, His Tag (active trimer) (MALS verified)
- 131XXXXXXX3
- 产品说明很详细。ox40ligand在不同状态下，与ox40结合活性相差很大。在研究过程中，正确选择active trimer和更倾向于形成dimer的其他tag蛋白，是关键。
- 2022-01-14
1人赞
OX40 Ligand 分子别名
OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1,CD134 ligand,CD134L
OX40 Ligand 分子背景
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
OX40 Ligand 前沿进展
OX40 Ligand临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| Oncolytic virus cancer therapeutics (DNAtrix) | MYX-135; DNX-2440; DNX-2450 | 临床一期 | Dnatrix Inc | 肝癌, 肾细胞癌, 胃癌, 胰腺癌, 结肠癌, 肿瘤, 肉瘤, 乳腺癌, 胃肠道间质瘤, 结直肠癌, 鳞状细胞癌, 黑色素瘤 | 详情 |
| SAR-443726 | SAR-443726 | 临床一期 | 赛诺菲 | 特应性皮炎 | 详情 |
| anti-cancer mRNA therapeutics (Moderna Therapeutics) | mRNA-2752 | 临床一期 | 阿斯利康 | 实体瘤, 淋巴瘤 | 详情 |
| RP-3 | RP-3 | 临床一期 | Replimune Inc | 实体瘤 | 详情 |
| mRNA-2416 | mRNA-2416; OX40L mRNA - Moderna Therpeutics | 临床二期 | Moderna Inc | 卵巢癌, 实体瘤, 淋巴瘤 | 详情 |
| Amlitelimab | KY-1005; SAR-445229 | 临床二期 | Kymab, 赛诺菲 | 自身免疫疾病, 免疫紊乱, 特应性皮炎, 湿疹 | 详情 |
