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GPCRs

背景
GPCRs(G-protein coupled receptors,G蛋白偶联受体)是人体中最大的膜蛋白家族,存在于体内所有的细胞中,能偶联多种配体,包括离子、神经递质、糖类、脂质、内源性多肽、蛋白酶等生物大分子,通过激活G蛋白和其他信号分子参与众多生理过程,包括肌肉收缩和松弛、神经信号传递、免疫系统调节及机体整体代谢等。GPCRs也是人体内最大的成药家族,涉及的疾病主要包括肿瘤、自身免疫、神经系统疾病、心血管疾病等,因此,GPCRs是治疗多种疾病的优秀的药物靶点。

经典的GPCRs结构示意图

GPCRs的结构
GPCRs的共同分子结构由7个跨膜α螺旋组成,这些结构域将受体分割为胞外N端,胞内C端,3个胞外环和3个胞内环。胞外环上包含有两个高度保守的半胱氨酸残基,它们可以通过形成二硫键稳定受体的空间结构。胞内环上有G蛋白结合位点。
由于GPCRs类靶点胞外露出部分有限、细胞表面表达低、蛋白聚集等因素,导致想要获得具有生物学活性的可溶性GPCRs抗原极其困难,全长结构以保证天然构象的GPCRs抗原对药物研发具有重要意义,为助力靶向GPCRs的药物研究,ACROBiosystems专门搭建了VLP, 膜蛋白-去垢剂,Nanodisc的平台化解决方案,为您提供全长GPCRs蛋白,如GPRC5DCXCR4CCR5CCR8等,可用于免疫、ELISA、SPR、BLI等场景。
产品信息
技术平台 分子 货号 产品描述 订购/预购
VLP技术平台 ADORA2A ADA-H52P4 Human ADORA2A Full Length Protein (VLP)

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CCR4 CC4-H52P3 Human CCR4 Full Length Protein (VLP)

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CCR5 CC5-H52P3 Human CCR5 Full Length Protein (VLP)

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CCR5 CC5-H52P5 Fluorescent Human CCR5 Full Length Protein (VLP)

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CCR7 CC7-H52P3 Human CCR7 Full Length Protein (VLP)

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CCR8 CC8-H52P4 Human CCR8 Full Length Protein (VLP)

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CNR1 CN1-H52P6 Human CNR1 Full Length Protein (VLP)

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CXCR3 CX3-H52P4 Human CXCR3 Full Length Protein (VLP)

订购

CXCR3 CX3-M52P7 Mouse CXCR3 Full Length Protein (VLP)

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CXCR4 CX4-H5219 Human CXCR4 / CD184 Full Length Protein (VLP)

订购

CXCR5 CX5-H52P4 Human CXCR5 Full Length Protein (VLP)

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CXCR6 CX6-H52P3 Human CXCR6 / CD186 Full Length Protein (VLP)

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EDNRB EDB-H52P7 Human EDNRB Full Length Protein (VLP)

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EDNRB EDB-HF2G4 Fluorescent Human EDNRB Full Length Protein (VLP)

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GPR56 GP6-H52P7 Human GPR56 Full Length Protein (VLP)

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GPRC5D GPD-H52P7 Human GPRC5D Full Length Protein (VLP)

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GPRC5D GPD-HF2G5 Fluorescent Human GPRC5D Full Length Protein (VLP)

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PAR1 PA1-H52P6 Human PAR1 Full Length Protein (VLP)

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PAR1 PA1-HF2G5 Fluorescent Human PAR1 Full Length Protein (VLP)

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PAR2 PA2-H52P7 Human PAR2 Full Length Protein (VLP)

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SMO SMO-H52P3 Human SMO Full Length Protein (VLP)

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SSTR2 SS2-H5216 Human SSTR2 Full Length Protein (VLP)

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SSTR2 SS2-HF2G3 Fluorescent Human SSTR2 Full Length Protein (VLP)

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VLP VLP-N5213 Virus-Like Particle (VLP) Protein Isotype Control

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VLP VLP-NF2P4 Fluorescent Virus-Like Particle (VLP) Protein Isotype Control

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膜蛋白-去垢剂技术平台 ADORA2A ADA-H52H5 Human ADORA2A Protein, His Tag (Detergent, Inhibitor added)

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CCR5 CC5-H52D1 Human CCR5 Protein, Flag,His Tag (Detergent)

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CXCR3 CX3-H52D5 Human CXCR3 Protein, Flag,His Tag (Detergent)

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CXCR5 CX5-H52D6 Human CXCR5 Protein, Flag,His Tag (Detergent)

订购

GLP1R GLR-H52D5 Human GLP1R Protein, Flag,His Tag (Detergent)

预购

GPRC5B GPB-H52D7 Human GPRC5B Protein, Flag,His Tag (Detergent)

订购

GPRC5D GPD-H52D3 Human GPRC5D Protein, Flag,His Tag (Detergent)

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GPRC5D GPD-H82D6 Biotinylated Human GPRC5D Protein, His,Avitag™&Flag Tag (Detergent)

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GPRC5D GPD-C52D3 Cynomolgus GPRC5D Protein, Flag,His Tag (Detergent) (SPR verified)

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- DC-11 200x DDM CHS buffer

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Nanodisc技术平台 GPRC5D GPD-H52D4 Human GPRC5D Protein, Flag,His Tag (Nanodisc)

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GPRC5D GPD-H82D4 Biotinylated Human GPRC5D Protein, His,Avitag™&Flag Tag (Nanodisc)

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GPRC5D GPD-C82D4 Cynomolgus GPRC5D Protein, Flag,His Tag (Nanodisc)

订购

MSP1D1 APO-H51H3 Human MSP1D1 Protein, His Tag (Nanodisc)

订购

MSP1D1 APO-H81Q5 Biotinylated Human MSP1D1 Protein, His,Avitag™ (Nanodisc)

订购

了解更多GPCRs相关信息

> 【前沿进展】屡次摘获诺贝尔奖,膜蛋白的能量超乎想象

> 【靶点聚焦】GPRC5D,治疗多发性骨髓瘤的下一个热门靶点

> 【靶点聚焦】七次跨膜蛋白CCR8:肿瘤治疗更有效更安全的靶点

> 【靶点聚焦】CXCR4,治疗艾滋病和癌症的“超能”靶点

> 【靶点聚焦】【靶点新势力】趋化因子受体CCR5,抗 HIV的优秀靶点

> 【靶点聚焦】ACRO“膜杰作”:全长七次跨膜蛋白SSTR2

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