Recombinant Proteins iso9001 ISO13485
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EpCAM信息

英文名称:Epithelial cell adhesion molecule
中文名称:上皮细胞粘附分子
靶点别称:Epithelial Cell Adhesion Molecule,Tumor-Associated Calcium Signal Transducer 1,Major Gastrointestinal Tumor-Associated Protein GA733-2,Cell Surface Glycoprotein Trop-1,Epithelial Glycoprotein 314,TROP1,KSA,Membrane Component, Chromosome 4, Surface Marker
上市药物数量:0
临床药物数量:5
最高研发阶段:申请上市

EpCAM Molecule Synonym Name

EPCAM,TACSTD1,TROP1,CD326,DIAR5,EGP2,EGP314,EGP40,ESA,GA733-2,HNPCC8,HNPCC-8,KS1/4,KSA,M4S1,MIC18,MK1

EpCAM 分子背景

EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

EpCAM 参考文献

EpCAM临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
M-701 M-701 临床一期 武汉友芝友生物制药有限公司 肿瘤, 腹水 详情
A-337 A-337 临床一期 健能隆医药 肿瘤
Anti-EPCAM CAR-T cell therapy (Sinobioway) 临床二期 北大未名细胞治疗中心 肝癌, 胃癌
Catumaxomab LP000 临床三期 Neovii Biotech, Trion Research 卵巢癌, 胃癌, 癌, 结肠癌, 卵巢上皮癌, 腹水, 乳腺癌 详情

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