EpCAM 靶点蛋白|抗体药物|临床药物信息

EpCAM信息

英文名称：Epithelial cell adhesion molecule
中文名称：上皮细胞粘附分子
靶点别称：Epithelial Cell Adhesion Molecule，Tumor-Associated Calcium Signal Transducer 1，Major Gastrointestinal Tumor-Associated Protein GA733-2，Cell Surface Glycoprotein Trop-1，Epithelial Glycoprotein 314，TROP1，KSA，Membrane Component， Chromosome 4， Surface Marker (35kD Glycoprotein)，Antigen Identified By Monoclonal Antibody AUA1，Human Epithelial Glycoprotein-2，Epithelial Cell Surface Antigen，CD326 Antigen，HEGP314，HNPCC8，Ep-CAM，DIAR5，EGP-2，EGP40，KS1/4，MK-1，M1S2，ESA，Ly74，TACST-1，CO-17A，17-1A，EGP34，HEA125，M

上市药物数量：0
临床药物数量：6
最高研发阶段：临床三期

EpCAM产品列表

筛选结果

产品库

在线 (12)

物种

标签

属性

Protein (12)

标记

货号	物种	产品描述
EPM-H5223	Human	Human EpCAM / TROP1 Protein, His Tag
EPM-C5227	Rhesus macaque	Rhesus macaque EpCAM / TROP1 Protein, His Tag
EPM-M5227	Mouse	Mouse EpCAM / TROP1 Protein, His Tag (MALS verified)
EPM-H8254	Human	Biotinylated Human EpCAM / TROP1, Fc Tag, ultra sensitivity (primary amine labeling)
EPM-H8223	Human	Biotinylated Human EpCAM / TROP1 Protein, His Tag, ultra sensitivity (primary amine labeling)
EPM-H5254	Human	Human EpCAM / TROP1 Protein, Fc Tag
EPM-H82E8	Human	Biotinylated Human EpCAM / TROP1 Protein, Avitag™,His Tag (MALS verified)
EPM-H82F9	Human	Biotinylated Human EpCAM / TROP1 Protein, Fc,Avitag™ (MALS verified)
EPM-HF255	Human	FITC-Labeled Human EpCAM / TROP1 Protein, Fc Tag
EPM-HF225	Human	FITC-Labeled Human EpCAM / TROP1 Protein, His Tag
EPM-H5255	Human	Human EpCAM / TROP1 Protein, Mouse IgG2a Fc Tag
EPM-H5259	Human	Human EpCAM / TROP1 Protein, Llama IgG2b Fc Tag, low endotoxin

EPM-H5254|Human EpCAM / TROP1 Protein, Fc Tag

136XXXXXXX6

1人赞

用来检测腹水的肿瘤细胞，效果还不错，可以检测到腹水中表达EpCAM阳性的肿瘤细胞，特异性还可以。服务还不错
2020-04-08

EPM-H5254|Human EpCAM / TROP1 Protein, Fc Tag

136XXXXXXX5

0人赞

用于检测未纯化上清中的双抗表达量，效果明显，曲线范围内能够检测到极低量的蛋白，灵敏度高，背景干扰小。技术支持提供的Potocol的参考价值非常高。尤其是对标准曲线的做法说明有详细的注释。
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2022-03-16

EpCAM 分子别名

EPCAM,TACSTD1,TROP1,CD326,DIAR5,EGP2,EGP314,EGP40,ESA,GA733-2,HNPCC8,HNPCC-8,KS1,4,KSA,M4S1,MIC18,MK1

EpCAM 分子背景

EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy.Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

EpCAM 前沿进展

EpCAM临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Anti-EPCAM CAR-T cell therapy (Sinobioway)		临床二期	北京北大未名生物工程集团有限公司	肝癌, 胃癌	详情
A-337	A-337	临床一期	Evive Biotech Ltd	肿瘤	详情
Tefibazumab	INH-H2002		百时美施贵宝		详情
Catumaxomab	LP000	临床三期	Trion Research, Neovii Biotech	胃癌, 腹水, 膀胱癌	详情
Anti-EPCAM CAR-T cell therapy (Zhejiang University)		临床一期	浙江大学	胃癌, 胰腺癌, 结直肠癌, 肝细胞癌	详情
Oportuzumab monatox	4D5MOCB-ETA; VB4-845; VB-4847; B-4845; VB-845	临床三期	Viventia Biotech, Sesen Bio	膀胱癌	详情
ING-1	ING-1		Xoma		详情
Solitomab	MT-110; AMG-110		Micromet		详情
Citatuzumab bogatox	VB6-845; VB6-845d		Viventia Biotech		详情
M-701	M-701	临床二期	武汉友芝友生物制药股份有限公司, 石药集团恩必普药业有限公司	胸水, 肿瘤, 腹水	详情

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EpCAM