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EpCAM信息

英文名称:Epithelial cell adhesion molecule
中文名称:上皮细胞粘附分子
靶点别称:Epithelial Cell Adhesion Molecule,Tumor-Associated Calcium Signal Transducer 1,Major Gastrointestinal Tumor-Associated Protein GA733-2,Cell Surface Glycoprotein Trop-1,Epithelial Glycoprotein 314,TROP1,KSA,Membrane Component, Chromosome 4, Surface Marker (35kD Glycoprotein),Antigen Identified By Monoclonal Antibody AUA1,Human Epithelial Glycoprotein-2,Epithelial Cell Surface Antigen,CD326 Antigen,HEGP314,HNPCC8,Ep-CAM,DIAR5,EGP-2,EGP40,KS1/4,MK-1,M1S2,ESA,Ly74,TACST-1,CO-17A,17-1A,EGP34,HEA125,M
上市药物数量:0
临床药物数量:6
最高研发阶段:临床三期

EpCAM产品列表

 
评论(3)
EPM-H5254|Human EpCAM / TROP1 Protein, Fc Tag
  1. 136XXXXXXX6
  2. 1人赞
  3. 用来检测腹水的肿瘤细胞,效果还不错,可以检测到腹水中表达EpCAM阳性的肿瘤细胞,特异性还可以。服务还不错
  4. 2020-04-08
EPM-H5254|Human EpCAM / TROP1 Protein, Fc Tag
  1. 136XXXXXXX5
  2. 0人赞
  3. 用于检测未纯化上清中的双抗表达量,效果明显,曲线范围内能够检测到极低量的蛋白,灵敏度高,背景干扰小。技术支持提供的Potocol的参考价值非常高。尤其是对标准曲线的做法说明有详细的注释。
  4. >
  5. 2022-03-16
EPM-H5223|Human EpCAM / TROP1 Protein, His Tag
  1. 949XXXXXXX
  2. 0人赞
  3. We received the product with a fairly fast speed, we used this product for antibody screening and ELISA. The product is robust and good quality.
  4. 2021-10-06
 

EpCAM 分子别名

EPCAM,TACSTD1,TROP1,CD326,DIAR5,EGP2,EGP314,EGP40,ESA,GA733-2,HNPCC8,HNPCC-8,KS1,4,KSA,M4S1,MIC18,MK1

EpCAM 分子背景

EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy.Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

EpCAM 前沿进展

EpCAM临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Anti-EPCAM CAR-T cell therapy (Sinobioway) 临床二期 北京北大未名生物工程集团有限公司 肝癌, 胃癌 详情
A-337 A-337 临床一期 Evive Biotech Ltd 肿瘤 详情
Tefibazumab INH-H2002 百时美施贵宝 详情
Catumaxomab LP000 临床三期 Trion Research, Neovii Biotech 胃癌, 腹水, 膀胱癌 详情
Anti-EPCAM CAR-T cell therapy (Zhejiang University) 临床一期 浙江大学 胃癌, 胰腺癌, 结直肠癌, 肝细胞癌 详情
Oportuzumab monatox 4D5MOCB-ETA; VB4-845; VB-4847; B-4845; VB-845 临床三期 Viventia Biotech, Sesen Bio 膀胱癌 详情
ING-1 ING-1 Xoma 详情
Solitomab MT-110; AMG-110 Micromet 详情
Citatuzumab bogatox VB6-845; VB6-845d Viventia Biotech 详情
M-701 M-701 临床二期 武汉友芝友生物制药股份有限公司, 石药集团恩必普药业有限公司 胸水, 肿瘤, 腹水 详情

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