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Apolipoprotein E信息

英文名称:Apolipoprotein E
中文名称:载脂蛋白E
靶点别称:APOE,Apolipoprotein E,Alzheimer Disease 2 (APOE*E4-Associated, Late Onset),Apolipoprotein E3,LDLCQ5,ApoE4,Apo-E,LPG,AD2,Apolipoproteins E
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

Apolipoprotein E 分子别名

Apolipoprotein E,APOE,Apo-E

Apolipoprotein E 分子背景

APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.

Apolipoprotein E 前沿进展

Apolipoprotein E临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
LX-1001 LX-1001 临床二期 LEXEO Therapeutics 阿尔茨海默病 详情
CN-105 CN-105 临床二期 Cerenova 脑出血, 中风 详情
AEM-28 AEM-28 Lipimetix 详情

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