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CXCR4信息

英文名称:C-X-C motif chemokine receptor 4
中文名称:C-X-C基序趋化因子受体4
靶点别称:C-X-C chemokine receptor type 4,FB22,Leukocyte-derived seven transmembrane domain receptor,SDF-1 receptor,CXC-R4,LAP-3,NPYRL,CXCR-4,LPS-associated protein 3,CD_antigen=CD184,LESTR,CXCR4,Fusin,HM89,Lipopolysaccharide-associated protein 3,LCR1,Stromal cell-
上市药物数量:1
临床药物数量:22
最高研发阶段:批准上市

CXCR4产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CX4-H5269
Human
Recombinant Human CXCR4 / CD184 / Fusin Protein
CX4-H5138
Human
Human-CXCR4-Protein-N-GST-Tag

CXCR4 分子别名

CXCR4,CD184,Fusin,D2S201E,FB22,HM89,HSY3RR,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM

CXCR4 分子背景

C-X-C chemokine receptor type 4 is also known as fusin or CD184 (cluster of differentiation 184), CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R or WHIM. CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these viruses are found late in infection. It is unclear as to whether the emergence of CXCR4 using HIV is a consequence or a cause of immunodeficiency.CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst, a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation. SDF-1 and CXCR4 were believed to be a relatively "monogamous" ligand-receptor pair (other chemokines tend to use several different chemokine receptors in a fairly "promiscuous" manner). Recent evidence demonstrates ubiquitin is also a natural ligand of CXCR4. Chronic exposure to THC increased T lymphocyte CXCR4 expression on both CD4+ and CD8+ T lymphocytes. Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells.

CXCR4 参考文献

CXCR4上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Plerixafor 普乐沙福 JM-3100; JKL-169; AMD-3100; SDZ-SID-791,JKL169,AMD 3100,JM3100,JM 3100,JKL 169,AMD3100 批准上市 健赞 MOZOBIL fda 多发性骨髓瘤, 非霍奇金淋巴瘤, 造血干细胞移植 GENZYME 2008-12-15 多发性骨髓瘤, 非霍奇金淋巴瘤, 造血干细胞移植 详情

CXCR4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
PF-06747143 PF-06747143 临床一期 辉瑞 急性粒细胞白血病 详情
LY-2510924 LY-2510924; T-134 临床二期 礼来 小细胞肺癌, 肾细胞癌 详情
Mavorixafor AMD-070; AMD-11070; X4P-001-RD; X4P-001-IO; X4P-001; X4P-001-LD 临床三期 健赞, X4 Pharmaceuticals 免疫缺陷性疾病 详情
Anti-CXCR4 monoclonal antibody (Lilly) 临床一期 礼来 癌症
Ulocuplumab BMS-936564; MDX-1338,BMS936564; MDX1338 临床二期 百时美施贵宝 小细胞肺癌, 多发性骨髓瘤, 急性骨髓性白血病, 胰腺癌 详情
ALX-404C 4C; ALX-40; ALX-40-4C; ALX-404C; ALX40-4; ALX40 临床二期 Shire 艾滋病
MSX-122 MSX-122; Q-122; WZ-40,MSX122,Q122, WZ40 临床二期 Altiris Therapeutics 血管舒缩症状, 潮热 详情
PTX-9908 PTX-9908 临床二期 Pertinax Therapeutics 肝癌 详情
NRP-2945 NNZ-4945; NRP-2945 临床一期 Neuren Pharmaceuticals 癫痫
BL-8040 TN-14003; T-140; 4F-Benzoyl-TN-14003; BKT-140; BL-8040; TF-14016,T140,4F-Benzoyl-TN14003,BKT140,BL8040 临床三期 Biokine, BioLineRx 干细胞移植 详情
ALX-0651 ALX- 0651 临床一期 Ablynx 癌症
CTCE-9908 CTCE-9908 临床二期 British Canadian BioSciences 实体瘤
USL-311 USL-311 临床二期 Ligand, Upsher Smith Laboratories 实体瘤, 成胶质细胞瘤 详情
Balixafortide POL-6326,POL6326 临床二期 Polyphor 组织损伤, 造血干细胞移植 详情
Burixafor Hydrobromide TG-0054,TG0054 临床二期 太景生物科技 造血干细胞移植 详情
vMIP (Jinan University) 临床二期 暨南大学 不明
CTCE-0214 CTCE-0214; CT-0214 临床一期 British Canadian BioSciences 干细胞移植
LEO-35299 LEO-35299 临床一期 利奥制药 银屑病 详情
GMI-1359 GMI-1359 临床一期 GlycoMimetics Pharmaceutical 实体瘤 详情
90Y-Pentixather 临床阶段不明 维尔茨堡大学, 慕尼黑工业大学 多发性骨髓瘤
JVS-100 ACRX-100; JVS-100; SRX-100 临床二期 Cleveland Clinic, Juventas Therapeutics, SironRX Therapeutics 外周缺血, 心力衰竭, 周边动脉血管疾病 详情
177Lu-Pentixather 临床阶段不明 维尔茨堡大学, 慕尼黑工业大学 白血病, 多发性骨髓瘤

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