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CXCR4信息

英文名称:C-X-C motif chemokine receptor 4
中文名称:C-X-C基序趋化因子受体4
靶点别称:NPYRL,CD184,CXCR4,CXC-R4,SDF-1 receptor,LAP-3,Fusin,FB22,HM89,Seven-Transmembrane-Segment Receptor, Spleen,Chemokine (C-X-C Motif), Receptor 4 (Fusin),Seven Transmembrane Helix Receptor,C-X-C Chemokine Receptor Type 4,Neuropeptide Y Receptor Y3,Neuropeptide Y3 Receptor,Chemokine Receptor,D2S201E,HSY3RR,NPYY3R,CXCR-4,NPY3R,WHIMS,LAP3,NPYR,WHIM,Receptors, CXCR4,LCR1,LESTR,LPS-associated protein 3,Leukocyte-Derived Seven Transmembrane Domain Receptor,Stromal Cell-Derived Factor 1 Receptor,Chemokine
上市药物数量:1
临床药物数量:15
最高研发阶段:批准上市

CXCR4产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CX4-H5269
Human
Human-CXCR4-Protein-N-Fc-Tag
CX4-H5219
Human
Human CXCR4 / CD184 Full Length Protein-VLP (HEK293)
 
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CXCR4 分子别名

CXCR4,CD184,Fusin,D2S201E,FB22,HM89,HSY3RR,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM

CXCR4 分子背景

C-X-C chemokine receptor type 4 is also known as fusin or CD184 (cluster of differentiation 184), CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R or WHIM. CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these viruses are found late in infection. It is unclear as to whether the emergence of CXCR4 using HIV is a consequence or a cause of immunodeficiency.CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst, a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation. SDF-1 and CXCR4 were believed to be a relatively "monogamous" ligand-receptor pair (other chemokines tend to use several different chemokine receptors in a fairly "promiscuous" manner). Recent evidence demonstrates ubiquitin is also a natural ligand of CXCR4. Chronic exposure to THC increased T lymphocyte CXCR4 expression on both CD4+ and CD8+ T lymphocytes. Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells.

CXCR4 前沿进展

CXCR4上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Plerixafor 普乐沙福 SDZ-SID-791; JM-3100; JKL-169; AMD-3100; PLR-001 批准上市 美国健赞公司 释倍灵, Mozobil, Mobozil Mainland China 非霍奇金淋巴瘤, 多发性骨髓瘤 Genzyme Europe Bv 2008-12-15 造血干细胞移植, 慢性髓细胞白血病, 霍奇金病, 肾脏疾病, 骨髓增生异常综合征, 器官移植排斥, 多发性骨髓瘤, 神经母细胞瘤, 脑癌, 尤因肉瘤, 急性淋巴细胞白血病, 非霍奇金淋巴瘤, 急性髓细胞样白血病, 淋巴瘤, 慢性淋巴细胞白血病 详情

CXCR4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Ulocuplumab MDX-1338; BMS-936564 临床二期 百时美施贵宝 白血病, 实体瘤, 胰腺癌, 小细胞肺癌, 多发性骨髓瘤, 滤泡中心淋巴瘤, B淋巴细胞白血病, 急性髓细胞样白血病, 慢性淋巴细胞白血病 详情
NRP-2945 NNZ-4945; NRP-2945 临床二期 Neuren Pharmaceuticals 癫痫 详情
Balixafortide POL-6326 临床三期 Polyphor Ltd 慢性髓细胞白血病, 骨髓增生异常综合征, 骨髓增生性疾病, 多发性骨髓瘤, 乳腺癌, 急性淋巴细胞白血病, 急性髓细胞样白血病, 慢性淋巴细胞白血病 详情
GMI-1359 GMI-1359 临床一期 Glycomimetics Pharmaceutical 乳腺癌, 转移性乳腺癌 详情
X-4136 X-4136 临床阶段不明 X4 Pharmaceuticals B-细胞淋巴瘤 详情
PTX-9908 PTX-9908 临床二期 Pertinax Therapeutics 肝癌, 肝细胞癌 详情
LY-2510924 T-134; LY-2510924 临床二期 礼来制药 实体瘤, 肾细胞癌, 小细胞肺癌 详情
AD-214 AD-214 临床一期 间质性肺疾病, 胃食管反流病 详情
MSX-122 Q-122; WZ-40; MSX-122 临床二期 Altiris Therapeutics 血管舒缩症, 实体瘤, 热潮红 详情
Motixafortide BKT-140; BL-8040; TF-14016; TN-14003; 4F-Benzoyl-TN14003 临床三期 Biokine 造血干细胞移植, 食道癌, 胰腺癌, 骨髓增生异常综合征, 多发性骨髓瘤, 再生障碍性贫血, 急性髓细胞样白血病, 非小细胞肺癌 详情
JVS-100 SRX-100; ACRX-100; GP-51801; GP51801; JVS-100 临床二期 Cleveland Clinic 心脏衰竭, 缺血, 外周动脉疾病 详情
[68Ga]Pentixafor 临床二期 The University Of Iowa 中枢神经系统肿瘤, 神经内分泌瘤, 诊断剂 详情
Mavorixafor AMD-11070; X4P-001-IO; AMD-070; X4P-001; X4P-001-RD; X4P-001-LD; ABSK-081 临床三期 美国健赞公司 HIV感染, WHIM综合征, 中性粒细胞减少, 肾细胞癌, 三阴性乳腺肿瘤, 华氏巨球蛋白血症, 黑色素瘤 详情

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