Mesothelin 靶点蛋白|抗体药物|临床药物信息

Mesothelin信息

英文名称：Mesothelin
中文名称：间皮素
靶点别称：MPF，Pre-pro-megakaryocyte-potentiating factor，CAK1 antigen，Mesothelin，Megakaryocyte-potentiating factor，MSLN，Mesothelin, cleaved form

上市药物数量：0
临床药物数量：14
最高研发阶段：临床二期

Mesothelin产品列表

货号	物种	产品描述
MSN-H826x	Human	Biotinylated Human MSLN /Mesothelin (aa 296-580) Protein,N-Fc Tag
MSN-H8223	Human	Human MSLN /Mesothelin (aa 296-580) Protein, Biotinylated
MSN-H5223	Human	Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-H526x	Human	Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-H5222	Human	Recombinant Human Mesothelin / MSLN Protein
MSN-H82E9	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag
MSN-H5253	Human	Human MSLN /Mesothelin (aa 296-580) Protein, Fc Tag
MSN-H522a	Human	Human Mesothelin / MSLN (296-580) Protein, low endotoxin
MSN-H82F6	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc Tag, Avi Tag
MSN-HF253	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF223	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein
MSN-HP223	Human	PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HG2P4	Human	GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HR2P4	Human	RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF25x	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag

Mesothelin 分子别名

MSLN,Mesothelin,MPF

Mesothelin 分子背景

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin 参考文献

Mesothelin临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
RG-7600	DMOT-4039A; RG-7600	临床一期	基因泰克	卵巢癌, 胰腺癌	详情
CART-meso	CART-meso	临床一期	宾夕法尼亚大学, 诺华	恶性间皮瘤, 卵巢癌, 胰腺癌	详情
MCY-M11	MCY-M11	临床一期	MaxCyte	胸膜间皮瘤, 卵巢癌	详情
Anti-mesothelin CAR T cell therapy (Shanghai GeneChem)		临床一期	上海吉凯基因	胰腺癌	详情
anti-mesothelin thorium-227 labeled antibody chelator conjugate	BAY-2287411	临床一期	拜耳	实体瘤	详情
KD-021 (Nanjing KAEDI Biotech)	KD-021	临床一期	南京凯地生物科技	实体瘤
Amatuximab	MORAb-009; MORAB-009-006	临床二期	美国国立癌症研究所, Morphotek	恶性间皮瘤, 实体瘤, 胰腺癌	详情
Anetumab ravantansine	BAY-94-9343,Anti-mesothelin antibody-drug conjugate BAY 94-9343,BAY-94-9343-SPDB-DM4	临床二期	拜耳, MorphoSys	非小细胞肺癌, 恶性间皮瘤, 实体瘤	详情
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute)		临床二期	上海细胞治疗研究院	实体瘤
LMB-100	LMB-100; RG-7787; RO-6927005,LMB100; RG7787; RO6927005	临床二期	罗氏, 美国国立癌症研究所, Selecta Biosciences	恶性间皮瘤, 胰腺癌	详情
iCasp9M28z	iCasp9M28z	临床一期	斯隆-凯特琳癌症中心	胸膜间皮瘤, 恶性间皮瘤, 乳腺癌, 肺癌, 转移性癌症	详情
BMS-986148	BMS-986148	临床二期	百时美施贵宝	实体瘤	详情
RNA-Meso-CIR-T	RNA-Meso-CIR-T	临床一期	宾夕法尼亚大学, 诺华	恶性间皮瘤
Anti-mesothelin CAR T-cell therapy (Marino Biotechnology)		临床一期	北京马力喏生物科技有限公司	癌症

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