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Mesothelin信息

英文名称:Mesothelin
中文名称:间皮素
靶点别称:Pre-pro-megakaryocyte-potentiating factor,Mesothelin,MSLN,CAK1 Antigen,MPF,Soluble MPF Mesothelin Related Protein,Megakaryocyte Potentiating Factor,SMRP,CAK1
上市药物数量:0
临床药物数量:12
最高研发阶段:临床二期

Mesothelin产品列表

 
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Mesothelin Molecule Synonym Name

MSLN,Mesothelin,MPF

Mesothelin 分子背景

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin 参考文献

Mesothelin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
iCasp9M28z iCasp9M28z 临床一期 Memorial Sloan Kettering Cancer Center 间皮组织肿瘤, 乳腺癌, 肺癌, 转移癌 详情
LMB-100 LMB-100; RG-7787; RO-6927005 临床二期 罗氏 肿瘤, 间皮组织肿瘤 详情
ATA-2271 ATA-2271 临床一期 Memorial Sloan Kettering Cancer Center, Atara Biotherapeutics 间皮组织肿瘤 详情
MCY-M11 MCY-M11 临床一期 Maxcyte 卵巢癌, 间皮组织肿瘤, 腹膜癌, 输卵管癌, 腺癌 详情
BMS-986148 BMS-986148 临床二期 百时美施贵宝 肿瘤 详情
RNA-Meso-CIR-T RNA-Meso-CIR-T 临床一期 诺华制药, 宾夕法尼亚大学 间皮组织肿瘤
Anetumab ravtansine BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343 临床二期 拜耳, Morphosys 卵巢癌, 肿瘤, 间皮组织肿瘤, 非小细胞肺癌 详情
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute) 临床二期 上海细胞治疗研究院 肿瘤
Amatuximab MORAb-009; MORAB-009-006 临床二期 美国国立癌症研究所 卵巢癌, 肿瘤, 胰腺癌, 间皮组织肿瘤, 非小细胞肺癌 详情
KD-021 (Nanjing KAEDI Biotech) KD-021 临床一期 Nanjing Kaedi Biotechnology Co Ltd 肿瘤
anti-mesothelin thorium-227 labeled antibody chelator conjugate BAY-2287411 临床一期 拜耳 间皮组织肿瘤 详情

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