Mesothelin 靶点蛋白|抗体药物|临床药物信息

Mesothelin信息

英文名称：Mesothelin
中文名称：间皮素
靶点别称：Pre-pro-megakaryocyte-potentiating factor，Mesothelin，MSLN，CAK1 Antigen，MPF，Soluble MPF Mesothelin Related Protein，Megakaryocyte Potentiating Factor，SMRP，CAK1

上市药物数量：0
临床药物数量：12
最高研发阶段：临床二期

Mesothelin产品列表

筛选结果

产品库

在线 (17)

物种

标签

属性

Protein (17)

标记

货号	物种	产品描述
MSN-H826x	Human	Biotinylated Human MSLN /Mesothelin (aa 296-580) Protein,N-Fc Tag
MSN-H8223	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, His Tag, ultra sensitivity (primary amine labeling)
MSN-H5223	Human	Human Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-H526x	Human	Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H5222	Human	Human Mesothelin / MSLN (37-286) Protein, His Tag
MSN-H82E9	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™ (MALS verified)
MSN-H5253	Human	Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H522a	Human	Human Mesothelin / MSLN (296-580) Protein, His Tag, low endotoxin
MSN-H82F6	Human	Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc,Avitag
MSN-HF253	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF223	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HP223	Human	PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HG2P4	Human	GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HR2P4	Human	RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF25x	Human	FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-M52H3	Mouse	Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-C52H6	Cynomolgus	Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)

Mesothelin Molecule Synonym Name

MSLN,Mesothelin,MPF

Mesothelin 分子背景

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin 参考文献

Mesothelin临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
iCasp9M28z	iCasp9M28z	临床一期	Memorial Sloan Kettering Cancer Center	间皮组织肿瘤, 乳腺癌, 肺癌, 转移癌	详情
LMB-100	LMB-100; RG-7787; RO-6927005	临床二期	罗氏	肿瘤, 间皮组织肿瘤	详情
ATA-2271	ATA-2271	临床一期	Memorial Sloan Kettering Cancer Center, Atara Biotherapeutics	间皮组织肿瘤	详情
MCY-M11	MCY-M11	临床一期	Maxcyte	卵巢癌, 间皮组织肿瘤, 腹膜癌, 输卵管癌, 腺癌	详情
BMS-986148	BMS-986148	临床二期	百时美施贵宝	肿瘤	详情
RNA-Meso-CIR-T	RNA-Meso-CIR-T	临床一期	诺华制药, 宾夕法尼亚大学	间皮组织肿瘤
Anetumab ravtansine	BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343	临床二期	拜耳, Morphosys	卵巢癌, 肿瘤, 间皮组织肿瘤, 非小细胞肺癌	详情
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute)		临床二期	上海细胞治疗研究院	肿瘤
Amatuximab	MORAb-009; MORAB-009-006	临床二期	美国国立癌症研究所	卵巢癌, 肿瘤, 胰腺癌, 间皮组织肿瘤, 非小细胞肺癌	详情
KD-021 (Nanjing KAEDI Biotech)	KD-021	临床一期	Nanjing Kaedi Biotechnology Co Ltd	肿瘤
anti-mesothelin thorium-227 labeled antibody chelator conjugate	BAY-2287411	临床一期	拜耳	间皮组织肿瘤	详情

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Mesothelin 重组蛋白