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IGF-II信息

英文名称:Insulin-like growth factor II
中文名称:胰岛素样生长因子Ⅱ
靶点别称:T3M-11-derived growth factor,PP1446,IGF2,Insulin-like growth factor II,Insulin Like Growth Factor 2,Preptin,IGF-II,Insulin-Like Growth Factor 2 (Somatomedin A),Chromosome 11 Open Reading Frame 43,Insulin-Like Growth Factor Type 2,Insulin-Like Growth Factor 2,Somatomedin-A,Somatomedin A,C11orf43,PP9974,GRDF,SRS3,FLJ44734
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

IGF-II 分子别名

IGF2,C11orf43,FLJ22066,FLJ44734,IGF-II,PP9974

IGF-II 分子背景

Insulin-like growth factor 2 (IGF-2) is also known as Somatomedin-A, IGF-II, PP9974, and is one of three protein hormones that share structural similarity to insulin. IGF-2 exerts its effects by binding to the IGF-1 receptor. IGF2 may also bind to the IGF-2 receptor (also called the cation-independent mannose 6-phosphate receptor), which acts as a signalling antagonist; that is, to prevent IGF2 responses. The major role of IGF2 is as a growth promoting hormone during gestation. In the process of Folliculogenesis, IGF2 is created by Theca cells to act in an autocrine manner on the theca cells themselves, and in a paracrine manner on Granulosa cells in the ovary. IGF2 promotes granulosa cell proliferation during the follicular phase of the menstrual cycle, acting alongside Follicle Stimulating Hormone (FSH). After ovulation has occurred, IGF-2 promotes progesterone secretion during the luteal phase of the menstrual cycle together with Luteinizing Hormone (LH). Thus, IGF2 acts as a Co-hormone together with both FSH and LH. IGF-2 may play a key role in memory and could potentially be used to treat Alzheimer's Disease. It is sometimes produced in excess in islet cell tumours, causing hypoglycemia. Doege-Potter syndrome is a paraneoplastic syndrome in which hypoglycemia is associated with the presence of one or more non-islet fibrous tumors in the pleural cavity. has been shown to interact with IGFBP3 and Transferrin.

IGF-II 前沿进展

IGF-II临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Dusigitumab MEDI-573 Medimmune Llc 详情
Xentuzumab BI-836845 勃林格殷格翰 详情

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