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 >  Antibody>Claudin-18.2 >HCS-S278

Recombinant Monoclonal Anti-Claudin-18.2 Antibody, Mouse (3B10)

描述/背景(Background)

The Claudin-18.2 (CLDN 18.2) protein, an isoform of Claudin 18, a member of the tight junction protein family, is a highly selective biomarker with limited expression in normal tissues and often abnormal expression during the occurrence and development of various primary malignant tumors, such as gastric cancer/gastroesophageal junction (GC/GEJ) cancer, breast cancer, colon cancer, liver cancer, head and neck cancer, bronchial cancer and non-small-cell lung cancer. Claudin-18.2 participates in the proliferation, differentiation and migration of tumor cells. Recent studies have identified Claudin-18.2 expression as a potential specific marker for the diagnosis and treatment of these tumors.

种属(Host Species)

Mouse

克隆号(Clone)

3B10

适用方法(Application)

IHC

效价(Property)

1:1000

状态(State)

Liquid

阳性对照(Positive Control)

Human Stomach Tissues

克隆类型(Clonality)

Monoclonal

分子别名(Synonym)

Claudin18.2, CLDN 18.2

研究领域(Research Field)

Cancer Drug Targets

抗体来源(Source)

Mouse

同种型(Isotype)

IgG

储存(Storage)

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

 

典型数据(Typical Data)

质控样本(Control Sample)

Claudin-18.2 CONTROL SAMPLE

Immunohistochemical analysis of paraffin embedded human stomach tissue labelled with HCS-S278 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Claudin-18.2 CONTROL SAMPLE

Immunohistochemical analysis of paraffin-embedded human lung tissue labeling Claudin-18.2 with HCS-S278 at 1/1000 dilution, followed by Goat Anti-Mouse IgG H&L (HRP) ready to use. The staining in the lung tissue sample was negative. Counter stained with Hematoxylin. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

肿瘤样本(Cancer Sample)

Claudin-18.2 CANCER SAMPLE

Claudin-18.2 CANCER SAMPLE

Immunohistochemical analysis of paraffin-embedded human cancer tissue labeling Claudin-18.2 with HCS-S278 at 1/1000 dilution, followed by Goat Anti-Mouse IgG H&L (HRP) ready to use. Membranous staining on tumor cells is observed. Counter stained with Hematoxylin. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

 

前沿进展

 
 
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Claudin-18.2靶点信息
英文全称:Claudin-18 splice variant 2
中文全称:密蛋白-18剪接变体2
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:61详情
最高研发阶段:批准上市
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