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Hemagglutinin (HA)信息

英文名称:Influenza virus hemagglutinin glycoproteins
中文名称:血凝素
靶点别称:Hemagglutinin,HA,Hemagglutinin Glycoproteins, Influenza Virus
上市药物数量:0
临床药物数量:8
最高研发阶段:临床二期

Hemagglutinin (HA) Molecule Synonym Name

HA,Hemagglutinin

Hemagglutinin (HA) 分子背景

Influenza, commonly known as "the flu", is an infectious disease of birds and mammals caused by RNA viruses of the family Orthomyxoviridae, the influenza viruses. The virus is divided into three main types (Influenzavirus A, Influenzavirus B, and Influenzavirus C), which are distinguished by differences in two major internal proteins (hemagglutinin (HA) and neuraminidase (NA), which are the most important targets for the immune system. The type A viruses are the most virulent human pathogens among the three influenza types and cause the most severe disease. The serotypes that have been confirmed in humans, ordered by the number of known human pandemic deaths, are: H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, H10N7, H7N9. H7N9 is a serotype of the species Influenzavirus A (avian influenza virus or bird flu virus). H7 normally circulates amongst avian populations with some variants known to occasionally infect humans. An H7N9 virus was first reported to have infected humans in 2013 in China.

Hemagglutinin (HA) 参考文献

Hemagglutinin (HA)临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Anti-influenza monoclonal antibody (AIMM Therapeutics) 临床一期 Aimm Therapeutics 流感病毒感染
CT-P27 CT-P27 临床二期 Celltrion 甲型流感病毒感染 详情
VIS-410 VIS-410 临床二期 Visterra 甲型流感病毒感染, 流感病毒感染 详情
MEDI-8852 MEDI-8852 临床二期 Humabs Biomed 甲型流感病毒感染, 流感病毒感染 详情
mRNA-1851 mRNA-1851; VAL-339851 临床一期 Modernatx, Valera Llc 甲型流感病毒感染 详情
Influenza vaccine quadrivalent (Nitto/Osaka) NSV-0001 临���一期 大阪大学, Nitto Denko 甲型流感病毒感染, 流感病毒感染 详情
Gedivumab RG-7745; MHAA-4549A 临床二期 基因泰克 甲型流感病毒感染, 流感病毒感染 详情
Diridavumab CR-6261; JNJ-54235025 临床二期 Crucell Holland Bv 甲型流感病毒感染, 流感病毒感染 详情

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