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Siglec-10信息

英文名称:Sialic acid-binding Ig-like lectin 10
中文名称:唾液酸结合免疫球蛋白样凝集素-10
靶点别称:UNQ477/PRO940,SIGLEC10,Sialic Acid Binding Ig Like Lectin 10,Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7,Siglec-Like Protein 2,Siglec-Like Gene 2,SLG2,Sialic Acid-Binding Ig-Like Lectin 10,Sialic Acid Binding Ig-Like Lectin 10,Siglec-10,PRO940,MGC126774
上市药物数量:0
临床药物数量:2
最高研发阶段:临床三期

Siglec-10产品列表

 
评论(4)
SI0-H525b|Human Siglec-10 Protein, Mouse IgG2a Fc Tag, low endotoxin
  1. 185XXXXXXX2
  2. 0人赞
  3. siglec家族的蛋白很不好验证,糖基化比较让人头疼,比较了好几家产品,Acro的有与tumor上CD24的binding,其他家的暂未发现有结合,买点ACRO的后续做免疫看看。
  4. 2022-03-03
SI0-H5253|Human Siglec-10 Protein, Fc Tag
  1. 180XXXXXXX7
  2. 1人赞
  3. 买这个主要目的是通过Elisa的方法检测我们的药物能否和该产品结合。通过摸索不同的包板浓度,达到了预期的目的。
  4. 2021-12-21
SI0-M52H7|Mouse Siglec-10 Protein, His Tag
  1. 151XXXXXXX5
  2. 2人赞
  3. 用购买的Siglec10蛋白测了流式实验 siglec10能够和靶细胞有很好的结合 结合是和唾液酸有相关性 实验重复性高 ACro是值得信赖的生物公司
  4. 2021-09-01
 

Siglec-10 分子别名

SIGLEC10,MGC126774,PRO940,Siglec10,SLG2

Siglec-10 分子背景

The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Siglec-10 前沿进展

Siglec-10临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
EXO-CD24 临床二期 Tel-Aviv Sourasky Medical Center 新型冠状病毒肺炎 详情
Efprezimod alfa CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 临床三期 Oncoimmune 白血病, 造血干细胞移植, HIV感染, 移植物抗宿主病, 新型冠状病毒肺炎, 骨髓增生异常综合征, 急性淋巴细胞白血病, 血脂障碍, 急性髓细胞样白血病, 黑色素瘤 详情

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