Recombinant Proteins iso9001 ISO13485
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 > 【Siglec-10】重组蛋白信息

Siglec-10信息

英文名称:Sialic acid-binding Ig-like lectin 10
中文名称:唾液酸结合免疫球蛋白样凝集素-10
靶点别称:UNQ477/PRO940,SIGLEC10,Sialic Acid Binding Ig Like Lectin 10,Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7,Siglec-Like Protein 2,Siglec-Like Gene 2,SLG2,Sialic Acid-Binding Ig-Like Lectin 10,Sialic Acid Binding Ig-Like Lectin 10,Siglec-10,PRO940,
上市药物数量:0
临床药物数量:1
最高研发阶段:临床三期

Siglec-10 Molecule Synonym Name

SIGLEC10,MGC126774,PRO940,Siglec10,SLG2

Siglec-10 分子背景

The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Siglec-10 参考文献

Siglec-10临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CD24-Fc HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110; CD24-Fc 临床三期 Oncoimmune HIV感染, 白血病, 新型冠状病毒肺炎, 移植物抗宿主病, 骨髓增生异常综合征, 急性淋巴细胞白血病, 血脂障碍, 急性髓细胞样白血病, 黑色素瘤 详情

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