Recombinant Proteins iso9001 ISO13485
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 > 【PVRIG】重组蛋白信息

PVRIG信息

英文名称:Transmembrane protein PVRIG
中文名称:跨膜蛋白PVRIG
靶点别称:PVRIG,PVR Related Immunoglobulin Domain Containing,CD112 Receptor,Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein,Poliovirus Receptor Related Immunoglobulin Domain Containing,Nectin-2 Receptor,C7orf15,CD112R,Transmembrane Protein PVRI
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

PVRIG Molecule Synonym Name

C7orf15,C7orf15MGC138295,CD112R,MGC104322,MGC138297,MGC2463,PVRIG,CD112 receptor

PVRIG 分子背景

Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. Notably, the intracellular domain of phatases. The extracellular domain sequence of human and mouse CD112R have 65.3% similarity. CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

PVRIG 参考文献

PVRIG临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
COM-701 COM-701 临床二期 Compugen 卵巢癌, 三阴性乳腺肿瘤, 乳腺癌, 结直肠癌, 子宫内膜样癌, 肺癌 详情

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