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LAIR-1信息

英文名称:Leukocyte-associated immunoglobulin-like receptor 1
中文名称:白细胞相关免疫球蛋白样受体-1
靶点别称:Immunoglobulin Heavy Chain Variable Region,HLAIR1,LAIR1,Leukocyte Associated Immunoglobulin Like Receptor 1,CD305 Antigen,hLAIR1,CD305,Leukocyte-Associated Ig-Like Receptor 1
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

LAIR-1产品列表

 
评论(3)
LA1-M5254|Mouse LAIR1 / CD305 Protein, Mouse IgG2a Fc Tag, low endotoxin
  1. 185XXXXXXX2
  2. 0人赞
  3. 买了鼠源的蛋白用于做交叉实验的,初筛孔得到很多与小鼠交叉的克隆,免疫效果不错,推荐使用his tag的做免疫。
  4. 2022-03-31
LA1-H5252|Human LAIR1 / CD305 Protein, Fc Tag (MALS verified)
  1. 185XXXXXXX2
  2. 1人赞
  3. 挺漂亮的cruve,第一遍就做出来了,4度保存了一个月拿出来重复了,依旧一样,稳定性还是蛮好的,后续打算用这个蛋白建立blocking assay,希望我的实验一切顺利
  4. >
  5. 2021-11-12
LA1-H5252|Human LAIR1 / CD305 Protein, Fc Tag (MALS verified)
  1. 135XXXXXXX7
  2. 0人赞
  3. 赶上公司做活动 做SPR还可以免费用他们家的蛋白 感觉简直是太赚了 第一次就做出来了 为了稳定结果 我要求重复几次 公司的技术老师很负责 直到做到满意为止 蛋白也好用 价格也不贵
  4. 2020-02-20
 

LAIR-1 分子别名

LAIR1,CD305

LAIR-1 分子背景

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

LAIR-1 前沿进展

LAIR-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
NC-410 临床二期 Nextcure 卵巢癌, 实体瘤, 胃癌, 结直肠癌 详情

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