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SCARB1信息

英文名称:Scavenger receptor class B member 1
中文名称:清道夫受体B类成员-1
靶点别称:CD36 Antigen,HDLQTL6,CLA-1,SR-BI,Collagen Type I Receptor, Thrombospondin Receptor-Like 1,Scavenger Receptor Class B, Member 1,Scavenger Receptor Class B Type III,CD36 Antigen-Like 1,CLA1,SRB1,CD36,SCARB1,Scavenger Receptor Class B Member 1,CD36 And LIMPII Analogous 1,CD36L1,CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 1
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

SCARB1 分子别名

SCARB1,CD36L1,SRB1,CLA-1,SR-BI,HDLQTL6

SCARB1 分子背景

Scavenger receptor class B member 1 (SRB1) is also known as SR-BI, CD36 and LIMPII analogous 1 (CD36L1), CLA-1, is a member of the scavenger receptor family or CD36 family. CD36L1 is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. SRB1 is receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. CLA-1 facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high-density lipoprotein (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus glycoprotein E2 in liver cells, and binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. SRB1 plays an important role in the uptake of HDL cholesteryl ester.

SCARB1 前沿进展

SCARB1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
ITX-5061 ITX-5061 临床二期 Itherx 丙型肝炎 详情

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