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Neuropilin-1信息

英文名称:Neuropilin-1
中文名称:神经毡蛋白-1
靶点别称:BDCA4,NP1,Neuropilin-1,NRP1,CD304,VEGF165R,Neuropilin 1,Vascular Endothelial Cell Growth Factor 165 Receptor,NRP,Transmembrane Receptor,CD304 Antigen
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

Neuropilin-1 分子别名

NRP1,Neuropilin-1,NRP,VEGF165R,CD304

Neuropilin-1 分子背景

Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.

Neuropilin-1 前沿进展

Neuropilin-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Vesencumab R-7347; RG-7347; M-1685-A; Anti-NRP1; MNRP-1685-A 基因泰克 详情
CEND-1 CEND-1; iRGD; CIND-1 临床二期 Drugcendr 结肠癌, 胰腺癌, 三阴性乳腺肿瘤, 胰腺导管癌, 胃肠道癌症 详情

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