登录 | 注册    关注公众号  
微信公众号
搜索
 > 【Follistatin】

Follistatin信息

英文名称:Follistatin
中文名称:卵泡抑素
靶点别称:Follistatin,Activin-binding protein
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

Follistatin产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
FON-H5256
Human
Human Follistatin Protein, Fc Tag
FON-H52H4
Human
Human Follistatin Protein, His Tag, premium grade
ACRO质量管理体系
 
评论(0)
 

Follistatin分子别名

Follistatin,FST,FS,FSP

Follistatin分子背景

Follistatin is also known as activin-binding protein, FST and FSH-suppressing protein (FSP), and is an secreted autocrine glycoprotein that is expressed in nearly all tissues of higher animals. Its primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone. Currently there are three reported isoforms, FS-288, FS-300, and FS-315. Two, FS-288 and FS-315, are known to be created by alternative splicing of the primary mRNA transcript. FS-300 (porcine follistatin) is thought to be the product of posttranslational modification via truncation of the C-terminal domain from the primary amino-acid chain. The activin-binding protein follistatin is produced by folliculostellate (FS) cells of the anterior pituitary. FS cells make numerous contacts with the classical endocrine cells of the anterior pituitary including gonadotrophs. In the tissues activin has a strong role in cellular proliferation. In the blood, activin and follistatin are both known to be involved in the inflammatory response following tissue injury or pathogenic incursion. Follistatin is involved in the development of the embryo. It has inhibitory action on bone morphogenic proteins (BMPs); BMPs induce the ectoderm to become epidermal ectoderm. Inhibition of BMPs allows neuroectoderm to arise from ectoderm, a process which eventually forms the neural plate. Other inhibitors involved in this process are noggin and chordin. Follistatin and BMPs are also known to play a role in folliculogenesis within the ovary. A study has also shown that increased levels of follistatin, by leading to increased muscle mass of certain core muscular groups, can increase life expectancy in cases of spinal muscular atrophy (SMA) in animal models.

Follistatin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AAV1-FS344 AAV1-Follistatin; AAV1-FS344 临床二期 Nationwide Children'S Hospital 贝克型肌营养不良, 包涵体肌炎, 杜氏肌营养不良症 详情

消息提示

请输入您的联系方式,再点击提交!

确定