膜杰作
Star Staining
分子别名（Synonym）
EDG8,Edg-8,S1P5,SPPR-1,SPPR-2
表达区间及表达系统（Source）
Human S1PR5 Full Length Protein (VLP) (S15-H52P7) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Asp 398 (Accession # Q9H228-1).
蛋白结构（Molecular Characterization）
Virus-like particles(VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrane Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.
制剂（Formulation）
Please contact us for detailed information.
Contact us for customized product form or formulation.
运输（Shipping）
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存储（Storage）
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- The product MUST be stored at -70°C or lower upon receipt;
- -70°C for 12 months under sterile conditions.
背景（Background）
Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions by engaging 5 G-protein-coupled
receptors (S1PR1-S1PR5). S1P receptors are involved in several cellular and physiological events, including lymphocyte/
hematopoietic cell trafcking. An S1P gradient (low in tissues, high in blood), maintained by synthetic and degradative
enzymes, regulates lymphocyte trafcking. Because lymphocytes live long (which is critical for adaptive immunity) and
recirculate thousands of times, the S1P-S1PR pathway is involved in the pathogenesis of immune-mediated diseases.
