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Human Claudin-18.1 Protein, His,Twin-Strep Tag (Detergent)

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分子别名(Synonym)

Claudin-18.1,CLDN18,Claudin-18

表达区间及表达系统(Source)

Human Claudin-18.1, His,Twin-Strep Tag (CL1-H5588) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ala 200 (Accession # P56856-1).

Predicted N-terminus: Met

蛋白结构(Molecular Characterization)

Claudin-18.1 Structure

This protein carries a polyhistidine tag at the N-terminus and a twin strep tag at the C-terminus.

The protein has a calculated MW of 26.5 kDa.

制剂(Formulation)

Please contact us for detailed information.

Contact us for customized product form or formulation.

运输(Shipping)

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储(Storage)

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. The product MUST be stored at -70°C or lower upon receipt;
  2. -70°C for 6 months under sterile conditions.
*The DDM/CHS buffer (Cat. No. DC-11) is sold separately and not included in protein, you can follow this link for product information.
 

背景(Background)

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]

 

前沿进展

 
 
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Claudin-18.1靶点信息
英文全称:Claudin-18 splice variant 2
中文全称:密蛋白-18剪接变体2
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:61详情
最高研发阶段:批准上市
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