IL-3 R alpha Molecule Synonym Name
IL3R,IL3RA,IL-3Ra,IL-3R-alpha,IL3RAY,IL3RX,IL3RY,CD123 antigen,CD123,hIL3Ra,hIL-3Ra,MGC34174,IL-3 R alpha
IL-3 R alpha 分子背景
Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.
IL-3 R alpha 参考文献
Mardiros A., et al. 2013, Blood., 122(18), 3138-48.
Rapoport AP., et al. 1996, Blood., 87(1), 112-22.
Klöß S., et al. 1996, Hum Gene Ther., 28(10), 897-913.
Wilkins A., et al., 2003, Curr Protein Pept Sci 4 (5): 367–73.
Yang J., et al., 2001, Curr Protein Pept Sci 2 (1): 1–17.
Bodian D.L., et al., 1994, Structure 2:755-766.