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Clusterin信息

英文名称:Clusterin
中文名称:丛生蛋白
靶点别称:Aging-associated gene 4 protein,Apo-J,Complement-associated protein SP-40,40,KUB1,Apolipoprotein J,Testosterone-repressed prostate message 2,CLI,Ku70-binding protein 1,Complement cytolysis inhibitor,CLU,APOJ,NA1/NA2
上市药物数量:0
临床药物数量:2
最高研发阶段:临床三期

Clusterin产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CLU-H5227
Human
Human Clusterin / CLUS Protein, His Tag
 
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Clusterin 分子别名

CLU,Clusterin,AAG4,APOJ,CLI,KUB1,SGP-2,SP-40,TRPM2

Clusterin 分子背景

Clusterin (CLU) is also known as dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI), is a secreted multifunctional glycoprotein protein which belongs to the clusterin family. Intracellular cleavages of the precursor of clusterin remove the signal peptide and generate comparably sized α and β chains which are secreted as an 80 kDa N­glycosylated disulfide­linked heterodimer. DAG protein is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. Clusterin involve in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Clusterin 参考文献

Clusterin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AB-16B5 AB-16B5; 16B5; AB-sCLU mAB 临床一期 National Research Council Biotechnology Research Institute, Alethia BioTherapeutics 实体瘤 详情
Custirsen Sodium ISIS-112989; OGX-011; TV-1011 临床三期 英国哥伦比亚大学, OncoGenex, Ionis 非小细胞肺癌, 前列腺癌 详情

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