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 > 【LRP-6】

LRP-6信息

英文名称:Low-density lipoprotein receptor-related protein 6
中文名称:低密度脂蛋白受体相关蛋白6
靶点别称:LDL Receptor Related Protein 6,LRP6
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

LRP-6 分子别名

LRP-6,LRP6

LRP-6 分子背景

LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.

LRP-6 前沿进展

LRP-6临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
BI-905677 BI-905677 临床一期 勃林格殷格翰 肿瘤 详情

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