IL-5 靶点蛋白|抗体药物|临床药物信息

IL-5信息

英文名称：Interleukin-5
中文名称：白细胞介素-5
靶点别称：T-cell replacing factor，IL5，Interleukin 5，Eosinophil Differentiation Factor，Colony-Stimulating Factor， Eosinophil，B-Cell Differentiation Factor I，Interleukin-5，IL-5，TRF，Interleukin 5 (Colony-Stimulating Factor， Eosinophil)，B Cell Differentiation Factor I，EDF

上市药物数量：2
临床药物数量：6
最高研发阶段：批准上市

IL-5产品列表

筛选结果

产品库

在线 (6)

物种

标签

属性

标记

货号	物种	产品描述
EP-128	Human	IL-5[Biotinylated]:IL-5Rα Inhibitor Screening ELISA Kit
IL5-C52H3	Cynomolgus	Cynomolgus IL-5 Protein, His Tag
IL5-H52H3	Human	Human IL-5 Protein, His Tag
IL5-H82Q5	Human	Biotinylated Human IL-5 Protein, His,Avitag™
IL5-M52H3	Mouse	Mouse IL-5 Protein, His Tag (MALS verified)
IL5-R52H4	Rabbit	Rabbit IL-5 Protein, His Tag

IL5-H82Q5|Biotinylated Human IL-5 Protein, His,Avitag™

158XXXXXXX8

2人赞

这个抗原亲测非常有用，几次检测亲和力结果都很稳定，数据重复率很高，推荐推荐！！Acro的包装很美观，满满的干冰。产品稳定性很高！值得信赖！
2022-02-09

IL5-H52H3|Human IL-5 Protein, His Tag

158XXXXXXX8

1人赞

购买此蛋白用于抗体筛选！Acro产品质量非常稳定，结果产出非常好。一如既往的值得信赖！从入职公司以来一直都在用Acro的产品，管线齐全，也能做到紧跟热门靶点。而且每次都发货很快，包装精美。会一直使用！
2021-12-21

IL5-M52H3|Mouse IL-5 Protein, His Tag (MALS verified)

166XXXXXXX7

1人赞

鼠源IL-5蛋白，带HIS 标签，我们使用ProA传感器检测，检测结果显示抗原抗体亲和力相比于人源蛋白没有很高亲和力。
2021-11-05

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IL-5 分子别名

IL-5,TRF,IL5,Interleukin-5

IL-5 分子背景

Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells. IL-5 is a 115-amino acid (in human, 133 in the mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease. Drugs that target IL-5 are mepolizumab and reslizumab.

IL-5 前沿进展

IL-5上市药物信息

英文名称	中文名称	研发代码	研发阶段	公司	最早商品名	最早批准国家	最早适应症	最早批准公司	最早批准日期	适应症	临床试验
Reslizumab		TRFK-5; CDP-835; SCH-5570; CEP-38072; CTx-55700; SCH-55700	批准上市	以色列梯瓦制药工业有限公司	Cinqair, Cinquil, Cinqaero	EU	哮喘	Teva Bv	2016-03-23	罗阿丝虫病, 高嗜酸性粒细胞综合征, 肺嗜酸粒细胞增多, 嗜酸性粒细胞性食管炎, 哮喘, 支气管炎	详情
Mepolizumab	美泊利单抗	SB-240563; 240563	批准上市	葛兰素史克	Bosatria, Nucala, 美泊利珠单抗	EU	嗜酸细胞肉芽肿, 鼻息肉, 高嗜酸性粒细胞综合征, 鼻窦炎	Glaxosmithkline Trading Services Ltd	2015-11-04	高嗜酸性粒细胞综合征, 韦格纳肉芽肿, Churg-trauss综合征, 病毒感染, 鼻息肉, 慢性荨麻疹, 嗜酸粒细胞增多症, 嗜酸性粒细胞性食管炎, 哮喘, 嗜酸细胞肉芽肿, 支气管炎, 鼻窦炎, 慢性阻塞性肺疾病, 筋膜炎, 特应性皮炎, 血管性水肿	详情

IL-5临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
long-acting anti-IL-5 mAb (GSK)		临床一期	葛兰素史克	哮喘	详情
Mepolizumab biosimilar(Bio Thera Solutions)		临床一期	百奥泰生物制药股份有限公司	自身免疫疾病, 鼻息肉, 鼻窦炎	详情
Recombinant anti-IL-5 humanized monoclonal antibody (Shanghai CP Guojian)	610	临床二期	三生国健药业（上海）股份有限公司	自身免疫疾病, 哮喘	详情
SHR-1703	SHR-1703	临床二期	苏州盛迪亚生物医药有限公司, 江苏恒瑞医药股份有限公司, 上海恒瑞医药有限公司	哮喘	详情
Mepolizumab biosimilar (CTTQ Pharma)		临床一期	正大天晴药业集团南京顺欣制药有限公司	韦格纳肉芽肿, 高嗜酸性粒细胞综合征, 血管炎, 鼻息肉, 哮喘, 嗜酸细胞肉芽肿, 鼻窦炎, 噬血细胞性淋巴组织细胞增多症	详情
Depemokimab	GSK-294; GSK3511294; GSK294; GSK-3511294	临床三期	葛兰素史克	高嗜酸性粒细胞综合征, Churg-trauss综合征, 鼻息肉, 血管炎, 哮喘, 嗜酸细胞肉芽肿, 鼻窦炎	详情

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IL-5